Generic Name: cabozantinib, Oral capsule

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SECTION 1 of 4

Highlights for cabozantinib

Oral capsule
1
CABOZANTINIB (KA boe ZAN ti nib) is a chemotherapy drug. It targets specific proteins within cancer cells and stops the cancer cell from growing. This medicine is used to treat thyroid cancer.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

cabozantinib Side Effects

Oral capsule

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bloody or black, tarry stools
  • breathing problems
  • changes in vision
  • chest pain or chest tightness
  • confusion, trouble speaking or understanding
  • feeling faint or lightheaded, falls
  • jaw pain, especially after dental work
  • red or dark-brown urine
  • redness, swelling, or sores on hands or feet
  • severe headaches
  • shortness of breath, chest pain, swelling in a leg
  • spitting up blood or brown material that looks like coffee grounds
  • stomach pain
  • sudden numbness or weakness of the face, arm or leg
  • sweating
  • swelling of the ankles, feet, hands
  • trouble swallowing
  • trouble walking, dizziness, loss of balance or coordination
  • unusual bruising or bleeding from the eye, gums, or nose

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • diarrhea
  • loss of appetite
  • nausea, vomiting
  • sore throat
  • weight loss
SECTION 3 of 4

cabozantinib May Interact with Other Medications

Oral capsule

This medicine may interact with the following medications:

-atazanavir

-carbamazepine

-clarithromycin

-grapefruit juice

-indinavir

-itraconazole

-ketoconazole

-nefazodone

-nelfinavir

-phenobarbital

-phenytoin

-rifabutin

-rifampin

-rifapentine

-ritonavir

-saquinavir

-St. John's Wort

-telithromycin

-voriconazole

SECTION 4 of 4

How to Use cabozantinib

Oral capsule

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not take with food. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding disorders
  • high blood pressure
  • liver disease
  • recent surgery
  • skin conditions or sensitivity
  • an unusual or allergic reaction to cabozantinib, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

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Last Updated: January 7, 2013

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