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Generic Name:

bendroflumethiazide-nadolol, Oral tablet

All Brands

  • Corzide
SECTION 1 of 4

Highlights for bendroflumethiazide-nadolol

Oral tablet
1

Nadolol/bendroflumethiazide is a combination medication. It is used to treat hypertension (high blood pressure).

2

This drug comes in the form of a tablet you take by mouth.

3

This medication is available as a brand-name drug called Corzide. It is also available as a generic drug.

4

More common side effects that can occur when taking this drug include dizziness, tiredness, nausea, vomiting, or headache.

5

Skipping doses or suddenly stopping this medication can have dangerous side effects. These include heart attack. Don’t stop taking this drug without your doctor’s guidance.

IMPORTANT INFORMATION

FDA warning

This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to drug effects that may be dangerous.

Heart warning. If you suddenly stop taking this medication, it can lead to chest pain and even heart attack. If you have heart disease and suddenly stop taking this medication, it can make your heart disease worse. If you need to stop taking this medication, the dosage should be gradually lowered over two weeks and your doctor should carefully monitor you. After stopping, if your chest pain becomes much worse or you develop other symptoms of heart disease, the medication may need to be restarted right away.

Surgery

This drug may increase your risk of adverse effects from general anesthesia used during surgery or from the surgical procedure itself. Talk to your doctor if you are going to have surgery and take this drug.

Heart failure

Long-term use of this drug can lead to or worsen heart failure. If you develop symptoms of heart failure or your symptoms worsen, tell your doctor right away. You will need to be monitored closely and treated. Symptoms of heart failure include tiredness, shortness of breath, or swelling in your legs, ankles or feet.

What is nadolol/bendroflumethiazide?

Nadolol/bendroflumethiazide is a prescription drug. It comes in the form of a tablet you take by mouth.

This medication is a combination of two drugs in a single form: nadolol and bendroflumethiazide. It is important to know about all the drugs in the combination because each drug may affect you in a different way.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

This medication is available as a brand-name drug called Corzide. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name drug. Talk to your doctor to see if the generic version will work for you.

Why it's used

Nadolol/bendroflumethiazide is used to treat high blood pressure.

How it works

The two drugs in this medication belong to two different drug classes.

More Details

How it works

The two drugs in this medication belong to two different drug classes. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Nadolol belongs to a class of drugs called beta-blockers. It causes the heart to beat more slowly and with less force. Bendroflumethiazide belongs to a class of drugs called thiazide diuretics. It removes excess water from your body so that your heart is not working as hard to pump blood. Both of these actions help to lower your blood pressure.

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SECTION 2 of 4

bendroflumethiazide-nadolol Side Effects

Oral tablet

More Common Side Effects

The more common side effects that can occur with use of this medication include:

  • dizziness

  • tiredness

  • nausea or vomiting

  • stomach upset, including diarrhea, constipation, indigestion, or gas

  • loss of appetite

  • rash

  • headache

  • dry mouth, eyes, or skin

  • decreased sex drive

  • facial swelling

  • weight gain

  • slurred speech

  • cough

  • stuffy nose

  • sweating

  • ringing in the ears

  • blurred vision

  • muscle spasm or weakness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  •  Severe slowing of heart rate. Symptoms can include:

    • lightheadedness
    • dizziness
    • fainting
  • Spasms of your bronchial tubes. Symptoms can include:

    • shortness of breath
    • wheezing
  • Very low white blood cell counts. Symptoms can include:

    • red or purple patches on your skin
    • prolonged or frequent infections
  • Low red blood cell counts. Symptoms can include:

    • tiredness
    • paleness
    • lightheadedness
    • fast resting heartbeat
  • Low platelets. Symptoms can include:

    • frequent nosebleeds
    • increased bleeding from gums
    • increased bleeding from cuts
    • frequent bruising
  • Electrolyte imbalances. Symptoms can include:

    • dry mouth
    • increased thirst
    • weakness
    • fatigue
    • restlessness
    • muscle pain or cramps
    • muscle weakness
    • urinating smaller amounts
    • fast heart rate
    • nausea
    • vomiting
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

bendroflumethiazide-nadolol May Interact with Other Medications

Oral tablet

Nadolol/bendroflumethiazide can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

Having drinks that contain alcohol while taking this medication can cause a quick drop in blood pressure when you change positions. This is called orthostatic hypotension. It can make you feel dizzy or faint when you stand after sitting or lying down.

Medications that might interact with this drug

Migraine and seizure drugs

Taking certain drugs for migraines or seizures, called barbiturates, while using this medication can cause a quick drop in blood pressure when you change positions. This is called orthostatic hypotension. It can make you feel dizzy or faint when you stand after sitting or lying down.

These drugs include:

  • butalbital
  • phenobarbital

Antifungal drugs

Some of these drugs can worsen problems with the body’s balance of electrolytes, such as potassium. (Electrolytes are salts and minerals that help manage fluid levels in the body.) Your doctor should monitor your potassium levels. You may need to take potassium supplements.

These drugs include:

  • amphotericin B

Diabetes drugs

Use of this nadolol/bendroflumethiazide can cause your blood sugar level to increase or decrease. Your diabetes drug dosages may need to be changed. These drugs include:

  • insulin
  • glimepiride
  • glyburide
  • glipizide
  • canaglifozin
  • empaglifozin
  • metformin
  • exenatide
  • liraglutide

General anesthetics

Having general anesthesia during surgery while taking this medication can cause very low blood pressure. Be sure to tell your surgeon you are taking this medication. These drugs include:

  • tubocurarine
  • atracurium
  • cisatracurium

Heart failure drugs

Using certain heart failure drugs along with this medication can increase your risk of a slow heart rate. These drugs include:

  • digoxin

Mood stabilizer drugs

Using lithium with this medication can increase the effects of lithium. This can increase your risk of side effects from lithium. Your doctor should monitor your lithium levels and adjust your dosage as needed. Side effects of lithium can include:

  • shaking or trembling
  • weakness
  • slurred speech
  • loss of coordination

Other blood pressure drugs

Taking other blood pressure drugs along with this medication may lower your blood pressure too much. This can cause dangerous side effects. These drugs include:

  • doxazosin
  • prazosin
  • terazosin
  • clonidine

Also, taking reserpine, a type of blood pressure drug, along with this medication can cause your heart rate to slow down too much.

Pain drugs

Taking drugs called narcotics while using this medication can cause a quick drop in blood pressure when you change positions. This is called orthostatic hypotension. It can make you feel dizzy or faint when you stand after sitting or lying down.

These drugs include:

  • oxycodone
  • hydrocodone
  • morphine
  • hydromorphone
  • methadone

Other drugs

Certain drugs used with this combination drug product can worsen problems with the balance of electrolytes in your body. This can especially affect your potassium level. Your doctor should closely monitor your potassium level. Your doctor may also suggest that you take potassium supplements.

These drugs include:

  • corticosteroids. Examples include:
    • prednisone
    • methylprednisolone
    • dexamethasone
    • corticotropin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
gout
People with gout

This medication may increase the amount of uric acid in your blood. This can affect how well your gout drug works. Your doctor may need to adjust the dosage of your gout drug.

heart failure
People with heart failure

The use of nadolol, one of the drugs in this combination medication, can make your heart failure worse. Before using this medication, be sure your doctor knows you have heart failure.

lung problems
People with certain lung problems

If you have a chronic obstructive pulmonary disease (COPD), such as bronchitis or emphysema, this medication may make your condition worse. Before using this medication, be sure your doctor knows you have COPD.

diabetes
People with diabetes

Nadolol, one of the drugs in this combination medication, may mask the symptoms of sudden low blood sugar. These symptoms include changes in heart rate and blood pressure. Nadolol may also decrease the amount of insulin your body releases in response to high blood sugar levels. Your doctor may need to change the dosage of your diabetes medication.

hypothyroidism
People with hyperthyroidism

Nadolol, one of the drugs in this combination medication, may mask symptoms of a high thyroid hormone level. These symptoms include a fast heart rate. If you are hyperthyroid, your doctor should monitor your thyroid hormone levels closely. Also, you should avoid suddenly stopping this medication.

kidney disease
People with serious kidney disease

Bendroflumethiazide, one of the drugs in this combination medication, can increase the amount of nitrogen in your blood. This can make your kidney disease worse. Before using this medication, be sure your doctor knows you have kidney disease.

liver disease
People with serious or progressive liver disease

Bendroflumethiazide, one of the drugs in this combination medication, can change your fluid and electrolyte balance. This can put you at risk for a serious condition called hepatic coma. Before using this medication, be sure your doctor knows you have liver disease.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This medication should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

This medication can pass into breast milk and may cause serious side effects in a child who is breast-fed. Tell your doctor if you breast-feed your baby. You should decide whether to stop breast-feeding or stop taking this medication.

allergies
Allergies

This medication can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
  • rash

Call 9-1-1 or go to the nearest emergency room if you have these symptoms.

Don’t take this drug again if you have ever had an allergic reaction to it before. Taking it a second time after any allergic reaction to it could be fatal. Also, do not take this medication if you are allergic to sulfonamide-derived drugs. These drugs are commonly called sulfa drugs.

SECTION 4 of 4

How to Take bendroflumethiazide-nadolol (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Corzide

Form: Oral tablet
Strengths:
  • 40 mg nadolol/5 mg bendroflumethiazide
  • 80 mg nadolol/5 mg bendroflumethiazide

Generic: nadolol/bendroflumethiazide

Form: Oral tablet
Strengths: 80 mg nadolol/5 mg bendroflumethiazide
Adult dosage (ages 18–64 years)

Your starting dose of this medication may be 40 mg nadolol/5 mg bendroflumethiazide, once daily. If needed, your doctor may increase your dose to 80 mg nadolol/5 mg bendroflumethiazide, once daily.

If needed, your doctor may start you on another blood pressure drug in addition to this drug. For this new drug, your doctor may start you at 50% of the usual starting dose. This can help prevent a dangerous drop in blood pressure.

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney failure: Your kidneys help remove this drug from your body. If your kidneys aren’t working well, your dosage of this medication may need to be decreased. This can help prevent the build-up of high levels of the drug in your body. Your dosage and how often you take this drug will be based on how well your kidneys clear a waste product called creatinine from your body. Your doctor can tell you more. If you have severe or moderate kidney disease, your doctor may instruct you to take this drug every 36 hours or 48 hours instead of once daily.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

Your blood pressure may rise. High blood pressure can cause serious complications. These include heart attack or stroke.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room. Signs and symptoms of overdose may include:

  • slow heartbeat
  • low blood pressure
  • shortness of breath
  • cramping
  • fainting
  • coma

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your blood pressure should go down. To find out your blood pressure level, you will need to have your doctor check it. You can also check it using a home blood pressure monitor.

This drug is used for long-term treatment.

Important considerations for taking this drug
can cut or crush
You can cut or crush the tablets
storage
Store this medication at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
sun sensitivity
Sun sensitivity
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.
prior authorization
Insurance
See Details

Store this medication at room temperature

  • Keep it from 68°F (20°C) to 77°F (25°C). Keep the drug away from high temperatures.
  • Keep the bottle tightly sealed. Don’t store this medication in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the temperature is very hot or very cold.

Self-management

Your doctor may suggest that you check your blood pressure on a regular basis. You can do this using a home blood pressure monitor. Your doctor can tell you where to buy this device and how to use it.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Electrolyte levels. Blood tests can check the levels of electrolytes in your body. Electrolytes are chemicals that help your cells perform many important functions. Blood pressure drugs can disrupt the balance of electrolytes in your body.
  • Kidney function. Blood tests can check how well your kidneys are working. If your kidneys aren’t working well, your doctor may decide to lower your dose of this drug.
  • Liver function. Blood tests can check how well your liver is working. If your liver isn’t working well, your doctor may decide to lower your dose of this drug.
  • Blood pressure. Your doctor may suggest that you check your blood pressure each day using a home blood pressure monitor.      

Sun sensitivity

This drug makes skin more sensitive to the sun. Your risk of sunburn is increased while you take this drug.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 22, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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