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Generic Name:

benazepril-hydrochlorothiazide, Oral tablet

All Brands

  • Lotensin HCT
SECTION 1 of 4

Highlights for benazepril-hydrochlorothiazide

Oral tablet
1

Benazepril/hydrochlorothiazide is a combination medication. It‘s used to treat high blood pressure (hypertension).

2

This drug comes in the form of a tablet you take by mouth.

3

This medication is available as a brand-name drug called Lotensin HCT. It’s also available as a generic drug.

4

More common side effects that can occur when taking this drug include headache, cough, dizziness, or sleepiness. They also include nausea or problems with sexual function.

5

This medication can cause a serious reaction called angioedema. It causes sudden swelling of the face, arms, legs, lips, tongue, or throat.

IMPORTANT INFORMATION

FDA warning

This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to drug effects that may be dangerous.

Pregnancy warning. Don’t take this medication if you’re pregnant or become pregnant. This drug can cause injury or death to a developing fetus. If you become pregnant, stop taking this medication right away and call your doctor.

Sudden swelling (angioedema)

This medication can cause sudden swelling of the face, arms, legs, lips, tongue, or throat. It can also cause swelling in your intestines. Tell your doctor right away if you have swelling in these areas, or have pain in your stomach area. Your doctor will likely stop the medication. They may also give you medication to reduce the swelling.

Low blood pressure

This medication can cause low blood pressure. This can make you feel lightheaded, especially during the first few days of treatment. Tell your doctor if this occurs, or if you have any fainting spells. Low blood pressure occurs more often in patients who aren’t drinking enough fluids. It’s also more common if you sweat more than normal, have diarrhea, or are vomiting.

Eye problems (acute glaucoma and myopia)

This medication can cause acute glaucoma and myopia (nearsightedness). Tell your doctor right away if you have pain in your eye(s), or changes in your vision.

What is benazepril/hydrochlorothiazide?

This drug is a prescription drug. It’s available as a tablet that you take by mouth.

This medication is a combination of two drugs in a single form: benazepril and hydrochlorothiazide. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.

This drug is available as a brand-name drug called Lotensin HCT. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name drug. Talk to your doctor to see if the generic version will work for you.

This drug may be used as part of a combination therapy. That means you may need to take it with other drugs.

Why it's used

This drug is used to treat high blood pressure (hypertension).

How it works

This medication belongs to a class of drugs called antihypertensives.

More Details

How it works

This medication belongs to a class of drugs called antihypertensives. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This medication works in different ways to help lower your blood pressure. Benazepril works to relax your blood vessels. Hydrochlorothiazide works to remove excess water from your body so that your heart isn’t working as hard to pump blood. Both of these actions help lower your blood pressure.

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SECTION 2 of 4

benazepril-hydrochlorothiazide Side Effects

Oral tablet

Most Common Side Effects

Some of the more common side effects that can occur with use of this medication include:

  • dizziness

  • tiredness

  • headache

  • cough

  • sleepiness

  • nausea

  • problems with sexual function

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Heart attack. Symptoms can include:

    • pain in the chest, jaw, or upper back
    • headache
    • nausea or vomiting
    • trouble breathing
  • Skin rash (Stevens-Johnson syndrome). Symptoms can include:

    • raised welts
    • facial swelling
    • hives
    • blistering, peeling skin
  • Sudden swelling (angioedema). Symptoms can include:

    • swelling of the face, lips, tongue, or throat
    • trouble breathing
    • pain in the abdomen (stomach area)
  • Infection. Symptoms can include:

    • fever
    • sore throat
  • Eye problems (acute myopia and glaucoma). Symptoms can include:

    • changes in vision
    • eye pain
  • Fast heartbeat

  • Feeling faint or falling

  • Trouble passing urine

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

benazepril-hydrochlorothiazide May Interact with Other Medications

Oral tablet

Benazepril/hydrochlorothiazide can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

Having drinks that contain alcohol while taking this medication can cause a quick drop in blood pressure when you change positions. This is called orthostatic hypotension. It can make you feel dizzy or faint when you stand after sitting or lying down.

Medications that might interact with this drug

Anti-anxiety drugs

Certain types of anti-anxiety drugs are called selective serotonin reuptake inhibitors (SSRIs). When taken with benazepril/hydrochlorothiazide, they can increase the risk of orthostatic hypotension. This condition causes low blood pressure when standing up after sitting or lying down. These drugs include:

  • citalopram
  • escitalopram
  • fluoxetine
  • paroxetine
  • sertraline

Blood pressure drugs

When taken with benazepril/hydrochlorothiazide, some blood pressure drugs can increase the effect of this medication. This can raise your risk of side effects from this drug. It can also raise your risk of low blood pressure. These drugs include:

  • angiotensin-converting enzyme (ACE) inhibitors such as:
    • benazepril
    • captopril
    • clizapril
    • enalapril
    • enalaprilat
    • fosniopril
    • imidapril
    • moexipril
    • perindopril
    • quinapril
    • ramipril
    • trandolapril
  • angiotensin II receptor blockers (ARBs) such as:
    • irbesartan
    • losartan
    • olmesartan
    • telmisartan
    • valsartan
  • beta-blockers such as:
    • acebutolol
    • arotinolol
    • atenolol
    • betaxolol
    • bisoprolol
    • esmolol
    • metoprolol
    • nadolol
    • nebivolol
    • penbutolol
    • pindolol
    • propranolol
    • timolol (systemic)
  • calcium channel blockers such as:
    • amlodipine
    • felodipine
    • nicardipine
    • nifedipine
  • loop diuretics such as:
    • bumetanide
    • furosemide
    • indapamide
    • torsemide
  • potassium-sparing diuretics such as:
    • eplerenone
    • spironolactone
    • triamterene
  • thiazide diuretics such as:
    • chlorothiazide
    • chlorthalidone
    • hydrochlorothiazide
    • methylclothiazide
    • metolazone

Also, using certain blood pressure drugs with this medication can increase your levels of potassium too much. (Potassium is a mineral that helps the nerves, muscles, and other parts of the body work properly.) These drugs include:

  • potassium-sparing diuretics such as:
    • eplerenone
    • spironolactone
    • triamterene
  • angiotensin-converting enzyme (ACE) inhibitors such as:
    • benazepril
    • captopril
    • clizapril
    • enalapril
    • enalaprilat
    • fosniopril
    • imidapril
    • moexipril
    • perindopril
    • quinapril
    • ramipril
    • trandolapril
  • angiotensin II receptor blockers (ARBs) such as:
    • irbesartan
    • losartan
    • olmesartan
    • telmisartan
    • valsartan

Cancer drugs

Using certain cancer drugs with this medication can increase your levels of potassium too much. (Potassium is a mineral that helps the nerves, muscles, and other parts of the body work properly.)  Having high levels of potassium in your body can cause dangerous side effects. These include heart rhythm problems and heart attack.

These cancer drugs are called antineoplastic agents. They include:

  • cyclophosphamide
  • methotrexate

Diabetes drugs

Use of this medication can increase the effects of certain diabetes drugs. This can increase your risk of side effects from these drugs. These drugs include:

  • pramlintide
  • metformin
  • exenatide
  • liraglutide
  • lixisenatide
  • saxagliptin
  • sitagliptin
  • insulin
  • nateglinide
  • repaglinide
  • glimepiride
  • glipizide
  • glyburide
  • canagliflozin
  • dapagliflozin
  • empagliflozin
  • pioglitazone
  • rosiglitazone

Heart drugs

Some heart drugs can increase the effect of this medication. This can raise your risk of side effects. These drugs include:

  • digoxen
  • digitoxin

Immunosuppressant drugs

Cyclosporine is a type of drug used to suppress the immune system. When taken with benazepril/hydrochlorothiazide, it raises your risk of kidney problems. It also raises your risk of gout-like problems. These include painful and tender skin at the hands, feet, or elbows.

Mood stabilizer drugs

Using lithium with this medication can increase the effects of lithium. This can increase your risk of side effects from lithium. These can include nausea, vomiting, cramping, diarrhea, and seizures.

Also, using lithium with this medication can increase your levels of potassium too much. (Potassium is a mineral that helps the nerves, muscles, and other parts of the body work properly.) Having high levels of potassium in your body can cause dangerous side effects. These include heart rhythm problems and heart attack.

Pain drugs

Some pain drugs can decrease the effect of this medication. This can prevent the medication from working well. These drugs include nonsteroidal anti-inflammatory drugs (NSAIDs) such as:

  • diclofenac
  • ibuprofen
  • indomethacin
  • ketoprofen
  • ketorolac
  • meloxicam
  • nabumetone
  • naproxen
  • piroxicam 

Other pain drugs called narcotics raise the risk of very low blood pressure when taken with benazepril/hydrochlorothiazide. These drugs include:

  • buprenorphine
  • codeine
  • dihydrocodeine
  • fentanyl
  • hydrocodone
  • hydromorphone
  • mepiridine
  • methadone
  • morphine
  • opium
  • oxycodone
  • oxymorphone
  • tramadol

Also, taking some pain drugs with this medication can increase your risk of kidney damage. These drugs include NSAIDs such as:

  • diclofenac
  • ibuprofen
  • indomethacin

Parkinson’s disease drugs

Biperiden is a medication used to treat Parkinson’s disease. When used with benazepril/hydrochlorothiazide, it can increase the levels of this drug in your body. This raises your risk of side effects.

Potassium supplements

Taking a potassium supplement along with this medication can increase your levels of potassium too much. (Potassium is a mineral that helps the nerves, muscles, and other parts of the body work properly.) Having high levels of potassium in your body can cause dangerous side effects. These include heart rhythm problems and heart attack.

Other drugs

Atropine is a drug often used to treat gastrointestinal spasms. When used with benazepril/hydrochlorothiazide, atropine can lower the amount of this medication in your body. This can prevent the medication from working well.

Drugs called barbiturates can decrease the effect of benazepril/hydrochlorothiazide. This can prevent the medication from working well. These drugs include:

  • butabarbital
  • butalbital
  • pentobarbital
  • phenobarbital
  • secobarbital

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
kidney disease
People with kidney disease

Your dose of this medication may need to be decreased. Or the medication may be stopped completely. Be sure to tell your doctor if you’re producing less urine than normal while being treated with this medication. This can be a sign of kidney failure.

liver disease
People with liver disease

Your dose of this medication may need to be decreased. Or the medication may be stopped completely. If you develop jaundice (yellowing of your skin or the whites of your eyes) while taking this drug, stop taking it right away and call your doctor.

lupus
People with lupus

This medication can cause a flare-up of lupus.

pregnant women
Pregnant women

This medication is a category D pregnancy drug.  That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

Talk to your doctor if you’re pregnant or planning to become pregnant. This medication should be used only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

This medication may pass into breast milk and may cause serious side effects in a breast-feeding child. Tell your doctor if you breast-feed your baby. You should decide whether to stop breast-feeding or stop taking this medication.

allergies
Allergies

This medication can cause a severe allergic skin reaction. Symptoms can include:

  • itching
  • rash
  • hives
  • blistering, peeling skin

If you have these symptoms, stop taking the medication and call your doctor right away.

Don’t take this drug again if you’ve ever had an allergic reaction to it, of if you’re allergic to sulfa or medications containing sulfa. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take benazepril-hydrochlorothiazide (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure

Brand: Lotensin HCT

Form: Oral tablet
Strengths:
  • 5 mg benazepril/6.25 mg hydrochlorothiazide
  • 10 mg benazepril/12.5 mg hydrochlorothiazide
  • 20 mg benazepril/12.5 mg hydrochlorothiazide
  • 20 mg benazepril/25 mg hydrochlorothiazide

Generic: benazepril/hydrochlorothiazide

Form: Oral tablet
Strengths:
  • 5 mg benazepril/6.25 mg hydrochlorothiazide
  • 10 mg benazepril/12.5 mg hydrochlorothiazide
  • 20 mg benazepril/12.5 mg hydrochlorothiazide
  • 20 mg benazepril/25 mg hydrochlorothiazide
Adult dosage (ages 18–64 years)
  • Your doctor will decide the dosage you’ll start on for the benazepril/hydrochlorothiazide combination product.
  • After 2 to 3 weeks, your doctor may increase your dosage if your blood pressure is not at the level that’s right for you.
  • The highest recommended dose of this medication is 20 mg benazepril/25 mg hydrochlorothiazide once daily.
  • If you’re switching to this medication from benazepril alone or hydrochlorothiazide alone, your starting dose will be different. In these cases, the usual recommended starting dose is 10 mg benazepril/12.5 mg hydrochlorothiazide once daily.
Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects. Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This medication comes with serious risks if you don't take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your blood pressure may increase. High blood pressure can cause serious complications. These include heart attack or stroke.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. If you think you’ve taken too much of the drug, act right away. Call your doctor or local poison control center, or go to the nearest emergency room. 

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your blood pressure should go down. To find out what your blood pressure is, you’ll need to have your doctor check it. Or, you can check it using a home blood pressure monitor.

This drug is used for long-term treatment.

Don’t store this drug above 86°F (30°C)

Don’t freeze this medication.

Keep this medication away from light. And don’t store it in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Be sure to carry with you the original prescription-labeled box.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the temperature is very hot or very cold.

Self-management

Your doctor may suggest that you buy a home blood pressure monitor. This device will allow you to check your blood pressure at home.

Clinical monitoring

You and your doctor should monitor your health. This can help make sure you stay safe while you take this drug. You’ll want to monitor health issues such as your:

  • Electrolyte levels. Blood tests can check the levels of electrolytes in your body. Electrolytes are chemicals that help your cells perform many important functions. Blood pressure drugs can disrupt the balance of electrolytes in your body.
  • Kidney function. Blood tests can check how well your kidneys are working. If your kidneys aren’t working well, your doctor may decide to lower your dose of this drug.
  • Liver function. Blood tests can check how well your liver is working. If your liver isn’t working well, your doctor may decide to lower your dose of this drug.
  • Blood pressure. Your doctor may suggest that you check your blood pressure each day using a home blood pressure monitor.

Sun sensitivity

This medication can make your skin more sensitive to the sun. This increases your risk of sunburn. Avoid the sun if you can. If you can’t, be sure to wear protective clothing and apply sunscreen.

Hidden costs

To help manage your blood pressure, you may need to have certain tests done. You may also need to purchase certain equipment.

  • Blood tests. These can help check your kidney and liver function, and the levels of electrolytes in your body.
  • Home blood pressure monitor. This device can help you check your blood pressure each day.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 9, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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