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Generic Name:

azilsartan, Oral tablet

All Brands

  • Edarbi
SECTION 1 of 5

Highlights for azilsartan

Oral tablet
1

Azilsartan is an oral drug that’s used to treat high blood pressure.

2

The recommended dose is 80 mg taken by mouth once per day. If you’re also taking a high dose of a water pill, your doctor may start you at 40 mg per day.

3

This drug may cause serious kidney damage. This may happen if you don’t have enough fluid in your blood vessels.

4

Common side effects include diarrhea and low blood pressure.

5

Azilsartan can harm or be fatal to your unborn baby. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. If you get pregnant while taking this drug, tell your doctor right away.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. This drug can harm or be fatal to your unborn baby. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. If you get pregnant while taking this, tell your doctor right away. Your doctor may switch you to a different medicine.

People with diabetes

If you’re taking the drug aliskiren and you have diabetes, you shouldn’t take this drug.

Kidney damage

This drug may cause you to not have enough fluid in your blood vessels. If you have heart failure or renal artery stenosis, eat a low salt diet, or are dehydrated, this can be dangerous. It may cause serious damage to your kidneys.

Combination therapy

If you’re taking other blood pressure medicines with this drug, you may have a higher risk of high blood potassium levels, kidney damage, and low blood pressure (hypotension).

What is azilsartan?

This drug is a prescription drug. It is available as an oral tablet.

This drug is available as a brand-name drug called Edarbi. It’s not available as a generic drug.

This drug may be taken in combination with other medicines for high blood pressure.

This drug may be taken as part of a combination therapy.

Why it's used

This drug is used to treat high blood pressure (hypertension) in adults.

How it works

This drug belongs to a class of drugs called angiotensin II receptor blockers (ARBs).

More Details

How it works

This drug belongs to a class of drugs called angiotensin II receptor blockers (ARBs). A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

This drug stops your blood vessel walls from tightening. This lowers your blood pressure.

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azilsartan Side Effects

Oral tablet

Most Common Side Effects

The most common side effects with azilsartan include:

  • diarrhea

  • low blood pressure and dizziness. This is most likely to happen if you also:

    • take water pills (diuretics)
    • eat a low salt diet
    • take other medicines that affect your blood pressure
    • get sick with vomiting or diarrhea
    • don’t drink enough fluids

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Azilsartan is a fairly new medicine and it isn’t known if it causes serious side effects.

If you think you are experiencing any serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

azilsartan May Interact with Other Medications

Oral tablet

Azilsartan can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions

Medications that might interact with this drug

Blood pressure drugs

If you’re taking other blood pressure drugs, you may have a higher risk of high blood potassium levels, kidney damage, and low blood pressure (hypotension).

These drugs include:

  • angiotensin II receptor blockers (ARBs), such as:
    • azilsartan (Edarbi, Edarbyclor)
    • candesartan (Atacand, Atacand HCT)
    • irbesartan (Avapro, Avalide)
    • losartan (Cozaar, Hyzaar)
    • olmesartan (Benicar, Benicar HCT, Tribenzor, Azor)
    • telmisartan (Micardis, Micardis HCT, Twynsta)
    • valsartan (Diovan, Diovan HCT, Exforge, Exforge HCT)
  • angiotensin-converting enzyme (ACE) inhibitors, such as:
    • benazepril (Lotensin, Lotrel)
    • captopril 
    • enalapril (Vasotec, Epaned)
    • fosinopril (Monopril)
    • lisinopril (Prinivil, Zestril, Prinzide, Zestoretic)
    • moexipril (Univasc)
    • perindopril (Aceon)
    • quinapril (Accupril, Accuretic)
    • ramipril (Altace)
    • trandolapril (Mavik, Tarka)
  • direct renin Inhibitor:
    • aliskiren (Tekturna, Tekturna HCT)

Pain drugs

Using azilsartan with non-steroidal anti-inflammatory drugs (NSAIDs) can increase your risk of kidney damage.

These drugs include:

  • NSAIDs, such as:
    • ibuprofen
    • naproxen

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
heart failure
People with heart failure

Your renin-angiotensin system is already working hard, and this drug may make it work harder. This can make your kidney function worse.

renal artery stenosis
People with renal artery stenosis

Your renin-angiotensin system is already working hard, and this drug may make it work harder. This can make your kidney function worse.

pregnant women
Pregnant women

This drug is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

This drug can harm or be fatal to your unborn baby. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. If you become pregnant while taking azilsartan, tell your doctor right away. They may switch you to a different medication.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause serious effects in a child who is breast-fed.

You and your doctor may need to decide if you’ll take this drug or breast-feed.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

allergies
Allergies

This drug can cause a severe allergic reaction, causing symptoms like:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

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How to Take azilsartan (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure (hypertension)

Brand: Edarbi

Form: Oral tablet
Strengths: 40 mg and 80 mg
Adult dosage (ages 18–64 years)

The recommended dose is 80 mg taken by mouth once per day. If you’re also taking a high dose of a water pill, your doctor may start you at 40 mg per day.

Child dosage (ages 0–17 years)

It isn’t known if azilsartan is safe and effective in children younger than 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Special considerations

Kidney or liver problems: There are no dosing changes if you have kidney or liver damage.

Azilsartan hasn’t been studied in people with severe liver damage, so your doctor may give you a different drug.

Warnings

If you are also taking a high dose of a water pill, your doctor may start you at a lower dose of 40 mg per day.

Taking azilsartan 80 mg per day with water pills, such as chlorthalidone or hydrochlorothiazide, may increase your serum creatinine levels. Serum creatinine is found in your blood. It increases when your kidneys aren’t working well. If you’re on one of these combinations, your doctor may check your serum creatinine blood levels to make sure your kidneys are working well.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all

If you don’t take this drug, your blood pressure can get worse. This may lead to serious problems, such as heart attack, stroke, and kidney damage.

If you stop taking it suddenly

Don’t stop taking this drug without talking to your doctor first. Your blood pressure can increase if you stop taking this drug suddenly. This may increase your chance for a heart attack or stroke.

If you don’t take it on schedule

If you don’t take this drug on schedule, your blood pressure may stay high. This can increase your chance for a stroke or heart attack. Remember to take your medication on schedule.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you take too much

It isn’t known what happens if you take too much this drug. Your blood pressure might become too low. Symptoms of low blood pressure include:

  • feeling faint or dizzy
  • lightheadedness
  • tiredness

If you think that you’ve taken too much of your this drug , call your doctor or poison control center right away or go to the emergency room.

How to tell the drug is working

You may be able to tell that this drug is working if your blood pressure is lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

This drug is a long-term drug treatment.

Important considerations for taking this drug

This drug must be stored at the right temperature

  • Store this drug at 77°F (25°C).
  • Don’t freeze this drug.
  • Keep this drug away from light.
  • Keep it away from high temperature.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you, such as in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling with your medication.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Self-management

You may need to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

You may need to buy your own blood pressure monitor so that you can check your blood pressure at home.

Clinical monitoring

Before starting and during treatment with this drug, your doctor may check the following:

  • blood cell counts. Your doctor may check your hemoglobin, hematocrit, and red blood cell levels to make sure that they haven’t decreased.
  • kidney function. Azilsartan can affect your kidney function.  

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

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How Much Does azilsartan Cost?

Oral tablet

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These prices represent the lowest priced national pharmacies for azilsartan on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 7, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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