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Generic Name:

aspirin-oxycodone, Oral tablet

All Brands

  • Percodan
  • Percodan-Demi (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 4

Highlights for aspirin-oxycodone

Oral tablet
1

Oxycodone hydrochloride/aspirin is an oral tablet usually taken as needed for pain.

2

This medication comes with the risk of opioid addiction, abuse, and misuse, which can lead to overdose and death.

3

It’s recommended to avoid alcohol while taking this medication. Drinking alcohol can increase the risk of side effects, such as drowsiness and the chance of developing a stomach ulcer.

4

The usual dosage is one tablet taken every 6 hours as needed for pain. In general, the total daily dose of aspirin should never be more than 4,000 mg or 12 tablets.

5

Oxycodone is a controlled substance. Selling or giving it away is against the law.

IMPORTANT INFORMATION

Addiction, abuse, and misuse

This medication comes with the risk of opioid addiction, abuse, and misuse, which can lead to overdose and death.

Dangerous shortness of breath

This drug can cause serious, life-threatening, or fatal inability to breathe. People older than 65 years or who have asthma or other respiratory conditions or who take too much of the drug are most at risk.

Decreased blood pressure

This medication may lower blood pressure. Contact your doctor if you experience dizziness, feeling faint, or trouble breathing.

Alcohol warning

Drinking alcohol while taking this drug can increase the risk of side effects, such as drowsiness and the chance of developing a stomach ulcer.

What is aspirin-oxycodone?

This drug is a prescription-only controlled substance. It’s available as an oral tablet.

This drug is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Why it's used

This drug is used to treat moderate to severe pain.

How it works

This medication contains oxycodone hydrochloride and aspirin.

More Details

How It Works

This medication contains oxycodone hydrochloride and aspirin. Oxycodone belongs to a class of drugs called opioids (narcotics). Aspirin is a salicylate analgesic (pain reliever).

This medication works in your brain to block your ability to feel pain. Aspirin also has anti-inflammatory effects.

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aspirin-oxycodone Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with this medication include:

  • lightheadedness

  • dizziness

  • drowsiness or sedation

  • nausea

  • vomiting

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe shortness of breath. This medication can cause a serious, life-threatening, or fatal inability to breathe.

  • low blood pressure. Symptoms may include:

    • dizziness
    • feeling faint
    • trouble breathing
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug may cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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aspirin-oxycodone May Interact with Other Medications

Oral tablet

This medication can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Drinking alcohol while taking this medication may increase you risk of side effects, such as drowsiness and stomach ulcers. Talk to your doctor if you drink alcohol.

Medications That Might Interact with This Drug

Drugs that cause drowsiness

Avoid taking oxycodone/aspirin with these medications. Combining them may increase your risk of drowsiness, physical and mental slowing, and trouble breathing. The dose of one or both drugs should be reduced if you need to take them together.

These drugs include:

  • sedative hypnotics
  • tranquilizers
  • general anesthetics (used in surgery)
  • skeletal muscle relaxants
  • other opioids

Opioid agonist/ antagonist analgesics

Avoid taking oxycodone/aspirin with these medications. Combining them can decrease how well your pain medication works, which may cause you to feel more pain.

These drugs include:

  • pentazocine
  • nalbuphine
  • butorphanol

Blood thinners

Avoid combining oxycodone hydrochloride/aspirin with blood thinners. Combining them can increase your risk of bleeding.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Avoid combining oxycodone hydrochloride/aspirin with NSAIDs. Combining them can increase your risk of bleeding and can harm your kidneys. 

These drugs include: 

  • aspirin
  • diclofenac
  • etodolac
  • fenoprofen
  • flurbiprofen
  • ibuprofen
  • indomethacin
  • ketoprofen
  • ketorolac
  • meclofenamate
  • meloxicam
  • nabumetone
  • naproxen
  • oxaprozin
  • piroxicam

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
hemophilia
People with hemophilia

Aspirin, one of the ingredients in this drug, can affect your body’s ability to clot blood. This drug may increase your risk of bleeding.

lung problems
People with lung problems

This drug may have negative effects on people with lung problems, including severe asthma and trouble breathing. If you have a lung problem, this medication may make it worse because the medication can slow your breathing.

stomach problems
People with stomach problems

The oxycodone in this drug slows down bowel function. Taking this medication if you have bowel blockages or constipation can decrease your ability to pass stool.

liver disease
People with liver disease

Depending on the severity of your liver disease, you may be started on a lower dose because this drug is processed in your liver. If your liver cannot process it quickly enough, too much of the drug could build up in your blood and cause more damage to your liver. If your liver disease is severe, you may not be able to take this drug.

kidney disease
People with kidney disease
Depending on the severity of your kidney disease, you may be started on a lower dose because this drug is removed through your kidneys. If your kidneys cannot remove it quickly enough, too much of the drug could build up in your blood and cause damage to your liver. If your kidney disease is severe, you may not be able to take this drug.
pregnant woman
Pregnant women

Aspirin is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Oxycodone hydrochloride is a pregnancy category B drug. For this category:

  1. Studies of the drug in pregnant animals have not shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show if the drug poses a risk to the fetus.

Speak with your doctor if you’re pregnant or plan to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

Don’t breastfeed your baby while taking this medication. If you do, your baby may experience serious side effects, such as trouble breathing, drowsiness, and withdrawal symptoms when the medication or breastfeeding is stopped.

seniors
For seniors

If you’re over 65 years old, your kidneys may not work as well and you may have a harder time clearing this drug from your body. You may be at a higher risk of having serious breathing problems and other side effects. Your doctor may give you a lowered dose of this medication.

telephone
When to call the doctor

Call your doctor or get emergency medical help if you have symptoms of overdose. Symptoms may include:

  • severe shortness of breath. This drug can cause serious, life-threatening, or fatal inability to breathe.
  • low blood pressure, which may cause dizziness, feeling faint, or breathing trouble.
allergies
Allergies

This medication can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
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How to Take aspirin-oxycodone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Moderate to severe pain
Form: Oral Tablet
Strengths: 325 mg oxycodone hydrochloride/4.835 mg aspirin
Adult Dosage (ages 18 years and older)

One tablet taken every 6 hours as needed for pain.

Child Dosage (ages 0-17 years)

Dosage information for people younger than 18 years hasn’t been established.

Special Considerations

Liver Disease: Depending on the severity of your liver disease, you may be started on a lower dose because this drug is processed in your liver. If your liver cannot process it quickly enough, too much of the drug could build up in your blood and cause more damage to your liver. If your liver disease is severe, you may not be able to take this drug.

Kidney Disease: Depending on the severity of your kidney disease, you may be started on a lower dose because this drug is removed through your kidneys. If your kidneys cannot remove it quickly enough, too much of the drug could build up in your blood and cause damage to your liver. If your kidney disease is severe, you may not be able to take this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

What to Do If You Miss a Dose

If you’re taking this medication regularly, take the missed dose as soon as you can. Skip the missed dose if it’s almost time for your next scheduled dose.

Don’t use extra medication to make up for the missed dose. This could result in toxic side effects.

How to Tell If the Drug Is Working

You may be able to tell this medication is working if you have decreased pain.

Is It a Short-Term or Long-Term Drug?

How long you take this medication depends on the nature of your pain. Your doctor will tell you when and how to stop taking it.

Take with food to reduce upset stomach

This medication may upset your stomach. Taking it with food or after meals may help.

Store in temperatures from 59–86°F (15–30°C)

Keep the drug away from high temperature and light.

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Airport X-ray machines can’t hurt this medication.
  • Since this is a controlled substance, you won’t have refills from your doctor. Be sure to check that you have enough medication before you leave on your trip.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this medication.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 4, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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