Amlodipine/valsartan | Side Effects, Dosage, Uses & More
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Generic Name:

amlodipine-valsartan, Oral tablet

All Brands

  • Exforge
SECTION 1 of 5

Highlights for amlodipine-valsartan

Oral tablet
1

Amlodipine/valsartan is used to treat hypertension (high blood pressure).

2

This medication contains two separate drugs: amlodipine and valsartan. Each drug works to lower your blood pressure in a different way.

3

This drug is available as a brand-name medication called Exforge. It’s also available as a generic drug.

4

This drug comes in the form of a tablet you take by mouth once each day.

5

Don’t take this medication if you are pregnant. It can cause serious harm to your pregnancy.

IMPORTANT INFORMATION

Drug features

Amlodipine/valsartan is a prescription drug. It’s available as a tablet that you take by mouth once each day.

This medication is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.

This medication is available as a brand-name drug called Exforge. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Talk to your doctor to see if the generic version will work for you.

Why it's used

Amlodipine/valsartan is used to treat high blood pressure.

How it works

Amlodipine belongs to a class of drugs called calcium channel blockers. Valsartan belongs to a class of drugs called angiotensin II receptor blockers.

See Details

How it works

Amlodipine belongs to a class of drugs called calcium channel blockers. Valsartan belongs to a class of drugs called angiotensin II receptor blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.   

Amlodipine and valsartan work in different ways to relax your blood vessels, which helps to lower your blood pressure. Amlodipine works by relaxing the muscles that tighten and narrow blood vessels. Valsartan works by blocking the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. This helps to relax and widen your blood vessels.

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amlodipine-valsartan Side Effects

Oral tablet

More Common Side Effects

The more common side effects that can occur with use of amlodipine/valsartan include:

  • dizziness

  • swelling of the hands, ankles, or feet

  • congestion in the nose

  • sore throat

  • head or chest cold

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Low blood pressure. Symptoms can include:

    • dizziness or feeling faint
    • chest pain
  • Kidney problems. Symptoms can include:

    • swelling of the hands, ankles, or feet
    • unexplained weight gain
  • Heart attack. Symptoms can include:

    • chest pain or tightness
    • shortness of breath
    • rapid heartbeat
    • discomfort in your upper body
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Worsening chest pain and heart attack can occur when you start to take amlodipine or increase the dose. Amlodipine is one of the drugs in this combination product. If you develop sudden or worsening chest pain after starting or increasing the dose of amlodipine/valsartan, call 9-1-1 or go to the nearest emergency room right away.

Amlodipine/valsartan may cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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amlodipine-valsartan May Interact with Other Medications

Oral tablet

Amlodipine/valsartan can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

Amlodipine/valsartan can cause low blood pressure. Your risk of low blood pressure is increased if you are on a low-salt diet. Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain.

Alcohol interaction

Avoid or limit alcohol intake while taking amlodipine/valsartan. This drug can cause low blood pressure. Your risk of low blood pressure is increased if you have drinks that contain alcohol. Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain.

Medications that might interact with this drug

Cholesterol drugs

Simvastatin is used to help manage cholesterol levels. Taking this drug with amlodipine, one of the drugs in this combination product, can greatly raise the amount of simvastatin in your body. This can lead to serious side effects, including liver damage, renal failure, and muscle pain and weakness.

Heart drugs

Using certain heart drugs with amlodipine/valsartan raises your risk of very low blood pressure and increased potassium levels. It can also harm your kidneys. Some examples of these drugs include:

  • angiotensin receptor blockers (ARBs), such as:
    • losartan
    • olmesartan
    • telmisartan
  • angiotensin-converting enzyme (ACE) inhibitors, such as:
    • enalapril
    • lisinopril
    • captopril

Mood stabilizers

Lithium is used to treat certain mood disorders. Taking lithium with amlodipine/valsartan can increase the level of lithium in your body. This raises your risk of side effects from lithium. These can include vomiting, seizures, or coma.

Pain drugs

In patients who are older or have kidney problems, the use of this medication along with NSAIDs (non-steroidal anti-inflammatory drugs) can cause serious kidney damage. Some examples of NSAIDs include:

  • ibuprofen
  • naproxen

Water pills (diuretics)

Amlodipine/valsartan can cause low blood pressure. Your risk of low blood pressure is increased if you also take water pills (diuretics). Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain. Some examples of diuretics include:

  • hydrochlorothiazide
  • furosemide

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart problems

This medication can cause low blood pressure. Your risk of lower blood pressure is increased if you have certain heart problems, such as congestive heart failure.

People with kidney problems

This medication can make kidney disease worse. Symptoms of worsening kidney disease include swelling in your hands, feet, or ankles, or unexplained weight gain.

People on kidney dialysis

This medication can cause low blood pressure. Your risk of lower blood pressure is increased if you are on dialysis.

Pregnant women

Amlodipine/valsartan is a category D pregnancy drug. That means two things:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Taking this drug during pregnancy can harm or even end your pregnancy. If you become pregnant while taking amlodipine/valsartan, stop taking it right away and call your doctor.

Women who are breast-feeding

This drug may pass into breast milk and cause side effects in a child who is breast-fed.

Talk to your doctor about whether you should stop breast-feeding or stop taking this medication.

For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

When to call the doctor

Call your doctor right away if you become pregnant while taking this drug

Allergies

Amlodipine/valsartan can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local Poison Control Center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you have ever had an allergic reaction to it before. Taking it a second time after any allergic reaction to it could be fatal (cause death).

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How to Take amlodipine-valsartan (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Exforge

Form: Oral tablet
Strengths:
  • 5 mg amlodipine/160 mg valsartan
  • 10 mg amlodipine/160 mg valsartan
  • 5 mg amlodipine/320 mg valsartan
  • 10 mg amlodipine/320 mg valsartan

Generic: amlodipine/valsartan

Form: Oral tablet
Strengths:
  • 5 mg amlodipine/160 mg valsartan
  • 10 mg amlodipine/160 mg valsartan
  • 5 mg amlodipine/320 mg valsartan
  • 10 mg amlodipine/320 mg valsartan
Adult dosage (ages 18 years and older)
  • Your doctor may start you on a dose of 5 mg amlodipine/160 mg valsartan, once daily.
  • If your blood pressure is not controlled after 1–2 weeks, your doctor may increase your dose to 10 mg amlodipine/160 mg valsartan. Your doctor may then increase it to 5 mg amlodipine/320 mg valsartan.
  • The maximum daily dose is 10 mg amlodipine/320 mg valsartan once daily.
Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney disease: This medication can cause high levels of a mineral called potassium in your body. If you have kidney problems, your risk of having high potassium levels is increased. To help prevent this, your doctor may prescribe a lower dose of this medication.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Amlodipine/valsartan comes with serious risks if you don't take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your blood pressure can increase and cause serious side effects. These include heart failure, kidney problems, vision problems, heart attack, or stroke.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well and your blood pressure may not be controlled. In order for this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • weakness
  • dizziness
  • a heartbeat that’s faster or slower than normal

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take it as soon as you remember. But if you remember just a few hours before the time for your next dose, only take one dose. Never try to catch up by taking two tablets at once. This could result in dangerous side effects, such as low blood pressure or heart attack.

How to tell if the drug is working

Your blood pressure should be lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this log with you to your doctor appointments.

Amlodipine/valsartan is used for long-term treatment.

Important considerations for taking amlodipine/valsartan
Do not crush, chew, or break the tablets
Store this drug carefully See Details
Prescription is refillable
travel Travel See Details
self-management Self-management See Details
clinical monitoring Clinical monitoring See Details
not usually stocked Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.
hidden costs Hidden costs See Details

Store this drug carefully

  • Store amlodipine/valsartan at room temperature from 59°F (15°C) to 86°F (30°C).
  • Keep this drug away from light. Don’t freeze it.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medicine in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

You may need to check your blood pressure at home. You can do this using a home blood pressure monitor. You should keep a log with the date, time of day, and your blood pressure readings. Bring this log with you to your doctor appointments.

Clinical monitoring

Your doctor will monitor your health while you’re taking this medication.

  • Kidney function: Blood tests can check how well your kidneys are working. If your kidneys aren’t working well, your doctor may lower your dose of this drug.
  • Potassium levels: A blood test can check the level of a mineral called potassium in your blood. If the level is too high, your doctor may lower your dose of this drug.

Hidden costs

Your doctor may suggest that you buy a home blood pressure monitor to check your blood pressure. This device can be found at many local pharmacies.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

What does the pill look like?

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How Much Does amlodipine-valsartan Cost?

Oral tablet

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Lowest price for amlodipine-valsartan

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These prices represent the lowest priced national pharmacies for amlodipine-valsartan on GoodRx. They may be lower than your insurance.

Show Sources

  • Exforge – amlodipine besylate and valsartan tablet, film coated. (2014, November). Retrieved from http://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=EXFORGE

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 24, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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