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Generic Name:

amlodipine-olmesartan, Oral tablet

All Brands

  • AZOR
SECTION 1 of 5

Highlights for amlodipine-olmesartan

Oral tablet
1

Amlodipine/olmesartan is a combination of two medications in a single form that work in different ways to treat hypertension (high blood pressure). It can be used alone or together with other blood pressure drugs.

2

The starting dose of amlodipine/olmesartan is 5 mg amlodipine/20 mg olmesartan taken by mouth one time per day. If your blood pressure is still high after 1–2 weeks, your doctor may increase your dose. The maximum dose is 10 mg amlodipine/40 mg olmesartan taken one time per day.

3

Tell your doctor if you’re pregnant or plan to become pregnant before you take this drug.

4

Tell your doctor about all other drugs that you’re taking. Your doctor will make sure that there are no interactions. 

5

Common side effects include swelling of your face, arms, hands, lower legs, or feet (edema), tiredness, dizziness, feelings of redness and warmth in your face (flushing), and a fast, fluttering, or pounding heart rate (palpitations).

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. Don’t take this drug if you’re pregnant. If olmesartan is taken during pregnancy, it can harm your unborn child. It can even be life-threatening to your baby. If you get pregnant, call your doctor and stop taking this drug right away.

Severe diarrhea

This drug may cause severe diarrhea that lasts a long time. This may make you lose weight. Diarrhea may develop months to years after you start taking this drug. If you have diarrhea that won’t go away, talk to your doctor. Your doctor will tell you to stop taking amlodipine.

Heart attack

If you have heart problems such as narrowing of your arteries, this drug may raise your risk of chest pain or a heart attack. Your risk may be higher after starting or increasing your dose of this drug. Call your doctor or go to the emergency room if you have chest pain.

Kidney problems

People with certain conditions, such as congestive heart failure and renal artery stenosis, may develop kidney problems while taking this drug. If this happens, your doctor will tell you to stop taking it. Call your doctor if you have symptoms of kidney problems, such as:

  • swelling in your feet, ankles, or hands (edema)
  • unexplained weight gain

What is amlodipine/olmesartan?

This drug is a prescription drug. It’s available as an oral tablet.

This drug is not available as a generic drug. It’s only available as a brand-name drug called Azor.

This is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique effects.

This drug may be taken as part of a combination therapy with other medications used to treat high blood pressure.

Why it's used

This drug is a combination of two medications in a single form that work in different ways to lower your blood pressure. It can be used alone or together with other blood pressure drugs. Lowering your blood pressure reduces your chance of having a stroke and heart attack (myocardial infarction).

How it works

This drug is a combination of two drugs in a single form. Amlodipine belongs to a class of drugs called calcium channel blockers (CCB). Olmesartan belongs to a class of drugs called angiotensin II receptor blockers (ARB).

More Details

How it works

This drug is a combination of two drugs in a single form. Amlodipine belongs to a class of drugs called calcium channel blockers (CCB). Olmesartan belongs to a class of drugs called angiotensin II receptor blockers (ARB). A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Amlodipine and olmesartan work in different ways to help control your high blood pressure. Amlodipine works directly to relax the muscles that tighten and narrow blood vessels. Olmesartan blocks the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. Both medications help to relax and widen your blood vessels. This lowers your blood pressure.

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SECTION 2 of 5

amlodipine-olmesartan Side Effects

Oral tablet

More Common Side Effects

The most common side effects that occur with amlodipine/olmesartan include:

  • swelling of your face, arms, hands, lower legs, or feet (edema)

  • tiredness or drowsiness

  • dizziness

  • feelings of redness and warmth

  • fast, fluttering, or pounding heart rate (palpitations)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reaction. Symptoms include:

    • swelling of your skin and the layers under your skin and your mucous membranes (inside your mouth)
    • itching and hives
    • feelings of redness and warmth in your face (flushing)  
    • feeling warm
    • swelling of your throat or tongue
    • wheezing or trouble breathing
    • fast and irregular heart rate
    • nausea, vomiting, or diarrhea
    • dizziness or fainting
  • low blood pressure (hypotension). Your risk of low blood pressure may be higher if you’re taking water pills (diuretics) or have lost a lot of water due to vomiting or diarrhea. Symptoms include:

    • lightheadedness
    • dizziness
  • chest pain or heart attack. Your risk may be higher if you have heart problems such as narrowing of your arteries. Symptoms include:

    • extreme pain or pressure in your chest
    • shortness of breath
  • kidney problems. Your risk may be higher if you have certain conditions. Symptoms include:

    • swelling in your feet, ankles, or hands (edema)
    • unexplained weight gain
  • severe diarrhea

  • high potassium levels in your blood (hyperkalemia). Amlodipine/olmesartan may increase the levels of potassium in your blood. Your risk may be higher if you have kidney problems or are taking potassium-sparing water pills (diuretics) or supplements. Your doctor will check your potassium levels while you’re taking this drug. Symptoms include:

    • fast, fluttering, or pounding heart rate (palpitations)
    • muscle weakness
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug may cause tiredness or drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

amlodipine-olmesartan May Interact with Other Medications

Oral tablet

Amlodipine/olmesartan can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Bipolar disorder and mania drugs

Amlodipine/olmesartan increases the levels of lithium in your body. This may cause more side effects. 

High cholesterol drugs

Amlodipine/olmesartan increases the levels of simvastatin (Zocor) in your body. This may cause more side effects. Your doctor may limit your simvastatin dose.

Colesevelam (Welchol) decreases the amount of amlodipine/olmesartan in your body. This means that it may not work as well to lower your blood pressure. You should take amlodipine/olmesartan at least 4 hours before you take colesevelam.

Potassium supplements

These drugs increase the potassium levels in your blood when you take them with amlodipine/olmesartan. This raises your risk of heart rhythm problems.


These drugs include:

  • potassium chloride (Klor-Con, Klor Con M, K-Tab, Micro-K)
  • potassium gluconate
  • potassium bicarbonate (Klor-Con EF)

Diuretics (water pills)

Certain water pills may increase the potassium levels in your blood when you take them with amlodipine/olmesartan. This may increase your risk of heart rhythm problems.

These drugs include:

  • potassium-sparing diuretics, such as:
    • spironolactone (Aldactone)
    • amiloride
    • triamterene (Dyrenium)

Other water pills may increase your risk for low blood pressure when taken with amlodipine/olmesartan.

These drugs include:

  • bendroflumethiazide (Corzide)
  • chlorothiazide (Diuril)
  • chlorthalidone
  • hydrochlorothiazide (Microzide)
  • indapamide
  • methyclothiazide
  • metolazone
  • bumetanide
  • ethacrynic acid (Edecrin)
  • furosemide (Lasix)
  • torsemide (Demadex)

Pain and osteoarthritis drugs

Certain pain and osteoarthritis drugs cause amlodipine/olmesartan to not work as well. They may also increase your risk of kidney problems.

These drugs include:

  • celecoxib (Celebrex)
  • diclofenac (Cataflam, Voltaren)
  • etodolac
  • fenoprofen  (Nalfon)
  • flurbiprofen
  • ibuprofen (Advil, Motrin)
  • indomethacin (Indocin)
  • ketoprofen
  • ketorolac
  • meclofenamate
  • mefenamic acid (Ponstel)
  • meloxicam (Mobic)
  • nabumetone
  • naproxen (Aleve, Naprosyn)
  • oxaprozin (Daypro)
  • piroxicam (Feldene)
  • sulindac (Clinoril)
  • tolmetin

High blood pressure or heart failure drugs

These drugs may increase your risk for low blood pressure, high potassium levels in your blood, and kidney problems when taken with amlodipine/olmesartan.

These drugs include:

  • angiotensin receptor blockers (ARB), such as:
    • azilsartan (Edarbi, Edarbyclor)
    • candesartan (Atacand, Atacand HCT)
    • eprosartan (Teveten, Teveten HCT)
    • irbesartan (Avapro, Avalide)
    • losartan (Cozaar, Hyzaar)
    • olmesartan (Benicar, Benicar HCT, Tribenzor, Azor)
    • telmisartan (Micardis, Micardis HCT, Twynsta)
    • valsartan (Diovan, Diovan HCT, Exforge, Exforge HCT)
  • angiotensin-converting enzyme (ACE) inhibitors, such as:
    • benazepril (Lotensin, Lotrel)
    • captopril 
    • enalapril (Vasotec, Epaned)
    • fosinopril (Monopril)
    • lisinopril (Prinivil, Zestril, Prinzide, Zestoretic)
    • moexipril (Univasc)
    • perindopril (Aceon)
    • quinapril (Accupril, Accuretic)
    • ramipril (Altace)
    • trandolapril (Mavik, Tarka)
  • direct renin inhibitor, such as:  
    • aliskiren (Tekturna, Tekturna HCT)

 

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
heart problems
People with heart problems

Use this drug with extreme caution if you have heart failure, narrowing of the aortic valve in your heart (aortic stenosis), or severe heart disease. This drug may cause more heart problems.

diabetes
People with diabetes

If you have diabetes, taking this drug with aliskiren may increase your risk of kidney problems, low blood pressure, and high levels of potassium in your blood.

high blood potassium
People with high blood potassium levels

This drug may increase the potassium levels in your blood. You shouldn’t take this drug if you already have high blood potassium levels (hyperkalemia). Your doctor will check your potassium levels regularly.

liver problems
People with liver problems

You shouldn’t take this drug if you have liver problems. Amlodipine is processed by your liver. If your liver isn’t working well, more of this drug can stay in your body longer and put you at risk for side effects.

kidney problems
People with kidney problems

Use this drug with caution if you have kidney problems. If you have kidney problems, your body may not be able to clear this drug as quickly. This may cause more of it to stay in your body longer and increase your risk for side effects. Your doctor will do tests to check if your kidneys are working well.

dehydrated
People who are dehydrated

This drug may lower your blood pressure too much if you’re dehydrated. You may become dehydrated if you don’t drink enough water or have vomiting or diarrhea.

pregnant women
Pregnant women

This drug is a category D pregnancy drug. That means two things:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

You shouldn’t start taking this drug if you’re 75 years of age or older.

As you age, your organs (such as your liver and kidneys) may not work as well as they did compared to when you were younger. More of the drug may stay in your body longer, putting you at risk for side effects.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

allergies
Allergies

This drug may cause a serious allergic reaction. Symptoms include:

  • swelling of your skin and the layers under your skin and your mucous membranes (inside your mouth)
  • itching and hives
  • feelings of redness and warmth in your face (flushing)  
  • feeling warm
  • swelling of your throat or tongue
  • wheezing or trouble breathing
  • fast and irregular heart rate
  • nausea, vomiting, or diarrhea
  • dizziness or fainting

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 5

How to Take amlodipine-olmesartan (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Azor

Form: Oral tablet
Strengths: 
  • 5 mg amlodipine/20 mg olmesartan
  • 10 mg amlodipine/20 mg olmesartan
  • 5 mg amlodipine/40 mg olmesartan
  • 10 mg amlodipine/40 mg olmesartan
Adult dosage (ages 18–74 years)
  • Initial therapy (if you’ve never taken drugs to control your high blood pressure):
    • starting dose: 5 mg amlodipine/20 mg olmesartan taken by mouth once per day
    • dose changes: If your blood pressure is still high after 1–2 weeks, your doctor may increase your dose. The full effect of this drug is seen within 2 weeks after a change in dose.
    • maximum dose: 10 mg amlodipine/40 mg olmesartan taken by mouth once per day
  • Replacement therapy:
    • starting dose: If you’re taking amlodipine and olmesartan separately, your starting dose of amlodipine/olmesartan may be the same as the doses of amlodipine and olmesartan you were taking separately. Your doctor may increase your dose of one or both drugs if your blood pressure needs to be reduced more.
    • dose changes: If your blood pressure is still high after 1–2 weeks, your doctor may increase your dose. The full effect of this drug is seen within 2 weeks after a change in dose.
    • maximum dose: 10 mg amlodipine/40 mg olmesartan taken by mouth once per day
  • Add-on therapy:
    • starting dose: Amlodipine/olmesartan may be used in people with high blood pressure that isn’t controlled with amlodipine alone (or another calcium channel blocker) or olmesartan alone (or another angiotensin receptor blocker). Your starting dose will depend on your current dose of amlodipine or olmesartan.
    • dose changes: If your blood pressure is still high after 1–2 weeks, your doctor may increase your dose. The full effect of this drug is seen within 2 weeks after a change in dose.
    • maximum dose: 10 mg amlodipine/40 mg olmesartan taken by mouth once per day
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Senior dosage (ages 75 years and older)

Seniors process amlodipine more slowly. A starting dose of 2.5 mg amlodipine is recommended. However, the lowest dose of amlodipine/olmesartan contains 5 mg of amlodipine. This drug isn’t recommended as a first treatment for high blood pressure in people ages 75 years and older.

Special considerations

Liver disease: People with liver disease process amlodipine more slowly. A starting dose of 2.5 mg amlodipine is recommended for people with liver disease. However, the lowest dose of amlodipine/olmesartan contains 5 mg of amlodipine. This drug isn’t recommended as a first treatment for high blood pressure in people with liver problems.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all or skip doses

If you don’t take this drug as prescribed by your doctor, your blood pressure may still be high. This increases your chance of having a stroke and heart attack.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you take too much

If you take too much of this drug, you may have the following symptoms:

  • severe low blood pressure (hypotension). Symptoms include:
    • feeling faint or dizzy
    • lightheadedness
    • tiredness
  • a dangerously fast heart rate (tachycardia)

If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room. 

How to tell if the drug is working

You may be able to tell that this drug is working if your blood pressure is lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

This drug is used for long-term treatment.

Important considerations for taking this drug
can crush or cut
You can crush or cut the tablet
storage
Store this drug at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
prior authorization
Insurance
See Details

Store this drug at room temperature

  • Keep it from 59°F (15°C) to 86°F (30°C). Keep it away from high temperature.
  • Keep this drug away from light.
  • Don’t freeze it.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.
  • Keep this drug and all drugs out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Before starting and during treatment with this drug, your doctor may check your:

  • blood pressure
  • potassium levels
  • liver function
  • kidney function

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does amlodipine-olmesartan Cost?

Oral tablet

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Lowest price for amlodipine-olmesartan

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These prices represent the lowest priced national pharmacies for amlodipine-olmesartan on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 23, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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