Advertisement

Generic Name:

amlodipine-hydrochlorothiazide-valsartan, Oral tablet

All Brands

  • Exforge HCT
SECTION 1 of 4

Highlights for amlodipine-hydrochlorothiazide-valsartan

Oral tablet
1

Amlodipine/valsartan/hydrochlorothiazide is a combination of three blood pressure medications in a single form. Each of these drugs works in a different way to lower your blood pressure. This drug is given when two medicines to lower your blood pressure aren’t enough.

2

Your doctor will decide a dose that’s right for you. This will be based on your blood pressure level and how you respond to this medicine. You’ll take amlodipine/valsartan/hydrochlorothiazide by mouth one time per day.

3

You shouldn’t take amlodipine/valsartan/hydrochlorothiazide if you can’t urinate or if you have diabetes and are taking aliskiren. Don’t take this drug if you’re allergic to sulfa or drugs that contain sulfa.

4

Tell your doctor if you’re pregnant or plan to become pregnant. You shouldn’t take this drug during pregnancy. It can harm your developing baby, and may even be fatal.

5

Common side effects include dizziness, swelling of your hands, ankles, or feet, headache, indigestion, tiredness, muscle spasms, back pain, and nausea.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. Tell your doctor if you’re pregnant or plan to become pregnant. You shouldn’t take this drug during pregnancy. It can harm your developing baby, and may even be fatal.

Heart problems

This drug can cause low blood pressure, new or worse chest pain, or a stroke or heart attack. Your risk may be higher if you have severe heart disease or kidney damage. This is most likely to occur after dose increases.

Kidney damage

This drug can cause changes in kidney function or kidney failure. Your risk may be higher if you have narrowing of the arteries that carry blood to the kidneys, chronic kidney disease, severe heart failure, or low blood volume.

Eye problems

This medicine can cause acute angle-closure glaucoma and myopia (nearsightedness). Tell your doctor right away if you have pain in your eye or vision changes.

What is amlodipine?

This drug is a prescription drug. It’s available as an oral tablet.

This drug is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This is a combination of three drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

This drug is used to treat high blood pressure. This drug is given when two medicines to lower your blood pressure aren’t enough.

How it works

This drug is a combination of three drugs that work in different ways to help lower your blood pressure.

More Details

How it works

This drug is a combination of three drugs that work in different ways to help lower your blood pressure.

  • Amlodipine belongs to a class of drugs called calcium channel blockers.
  • Valsartan belongs to a class of drugs called angiotensin II receptor blockers.
  • Hydrochlorothiazide belongs to a class of drugs called diuretics.

A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Amlodipine blocks calcium channels. This relaxes the muscles that tighten and narrow blood vessels. Valsartan blocks the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. This helps to relax and widen your blood vessels. Hydrochlorothiazide may work by removing sodium (salt) and water from your body. All of these actions together reduce your blood pressure.

Advertisement
SECTION 2 of 4

amlodipine-hydrochlorothiazide-valsartan Side Effects

Oral tablet

More Common Side Effects

The most common side effects that occur with amlodipine/valsartan/hydrochlorothiazide include:

  • dizziness

  • swelling of your hands, ankles, or feet

  • headache

  • indigestion

  • tiredness

  • muscle spasms

  • back pain

  • nausea

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • low blood pressure. Symptoms include:

    • lightheadedness
    • feeling like you’re going to faint
  • skin rash

  • eye problems. Symptoms include:

    • blurred vision
    • loss of vision
    • eye pain
  • heart problems. Symptoms include:

    • fast heart rate
    • chest pain
  • kidney problems. Symptoms include:

    • swelling of your ankles, hands, or feet that doesn’t go away
    • unexplained weight gain
  • worsening chest pain and heart attack. Symptoms include:

    • chest pain
    • a headache
    • jaw pain
    • upper back pain
    • nausea or vomiting
    • trouble breathing
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

amlodipine-hydrochlorothiazide-valsartan May Interact with Other Medications

Oral tablet

Amlodipine/valsartan/hydrochlorothiazide can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Cholesterol drugs

Amlodipine/valsartan/hydrochlorothiazide increases the amount of certain cholesterol drugs in your body. This means that you may have more side effects, such as muscle pain and weakness.

These drugs include:

  • simvastatin

Other cholesterol drugs may increase the amount of amlodipine/valsartan/hydrochlorothiazide in your body. This means you may have more side effects.

These drugs include:

  • cholestyramine
  • colestipol

Depression drugs

Fluoxetine increases the amount of amlodipine/valsartan/hydrochlorothiazide in your body. This means that you may have more side effects.

Diabetes drugs

Amlodipine/valsartan/hydrochlorothiazide may either increase or decrease the amount of diabetes drugs in your body.

These drugs include:

  • insulin
  • glipizide
  • glyburide
  • pioglitazone
  • rosiglitazone
  • acarbose
  • miglitol
  • sitagliptin
  • saxagliptin

Human immunodeficiency virus (HIV) and hepatitis C virus drugs

Taking certain drugs used to treat HIV or hepatitis C virus increases the amount of amlodipine/valsartan/hydrochlorothiazide in your body. This means that you may have more side effects.

These drugs include:

  • clarithromycin
  • erythromycin
  • ritonavir

Mood stabilizer drugs

Amlodipine/valsartan/hydrochlorothiazide increases the amount of lithium in your body. This means that you may have more side effects.

Pain drugs

Certain pain drugs increase your risk of kidney damage when taken with amlodipine/valsartan/hydrochlorothiazide.

These drugs include:

  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • ibuprofen
    • naproxen
    • celecoxib (Celebrex)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
kidney disease
People with kidney disease

This drug is cleared by your kidneys. If your kidneys aren’t working as well as they should, more of this drug may stay in your body. This raises your risk of side effects. You shouldn’t use this drug if you have severe kidney damage.

liver disease
People with liver disease

This drug is processed by your liver. If your liver isn’t working as well as it should, more of this drug may stay in your body. This raises your risk of side effects. If you have liver damage or liver disease, your dose may need to be adjusted.

pregnant women
Pregnant women

This drug is a category D pregnancy drug. That means two things:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take amlodipine-hydrochlorothiazide-valsartan (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Exforge HCT

Form: Oral tablet
Strengths: 
  • 5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide
  • 10 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide
  • 5 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide
  • 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide
  • 10 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide

Generic: amlodipine/valsartan/hydrochlorothiazide

Form: Oral tablet
Strengths: 
  • 5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide
  • 10 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide
  • 5 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide
  • 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide
  • 10 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide
Adult dosage (ages 18–64 years)

Your dose depends on your current doses of amlodipine, valsartan, and/or hydrochlorothiazide. This drug is taken one time per day. Your doctor may increase your dose after two weeks of treatment.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all

If you don’t take this drug, your blood pressure might not be controlled. This can lead to a heart attack or stroke.

If you skip or miss doses

If you don’t take this drug, your blood pressure might not be controlled. This can lead to a heart attack or stroke.

If you take too much

If you take too much of this drug, you could have the following symptoms:

  • weakness
  • dizziness
  • feeling like your heart is pounding or beating slower

If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room. 

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time of your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

How to tell if the drug is working

You may be able to tell that this drug is working if your blood pressure is lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

This drug is used for long-term treatment.

Important considerations for taking this drug

Store this drug at room temperature

Keep it from 59–86°F (15–30°C).

Don’t freeze this drug.

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

You may need to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments. 

Clinical monitoring

Before starting and during treatment with this drug, your doctor will check your:

  • liver function
  • kidney function
  • blood pressure
  • blood sugar levels
  • blood cell counts
  • electrolyte levels

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 22, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Advertisement
Advertisement
Advertisement