Amlodipine/benazepril | Side Effects, Dosage, Uses & More

Generic Name:

amlodipine-benazepril, Oral capsule

All Brands

  • Lotrel
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Highlights for amlodipine-benazepril

Oral capsule
1

Amlodipine/benazepril is an oral drug that’s used to treat high blood pressure. It’s given when other medicines by themselves haven’t worked to lower your blood pressure.

2

The normal adult dose is 2.5 mg amlodipine/10 mg benazepril–10 mg amlodipine/40 mg benazepril. Your doctor may change your dose after 7–14 days based on your blood pressure goals.

3

Common side effects include cough, dizziness, headache, and swelling of your feet, ankles, and hands.

4

If you become pregnant, you should stop taking amlodipine/benazepril right away. This drug can harm your developing baby. It can even be fatal.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. You shouldn’t take this drug during pregnancy. It can harm your developing baby, and may even be fatal. If you become pregnant, you should stop taking this drug right away.

Risk of allergic reaction

This drug can cause a serious allergic reaction. This can be fatal. Allergic reactions usually happen after one of your first doses, but they sometimes don’t occur until you’ve been taking this drug for months. These allergic reactions are rare, but happen more often in African Americans.

Low blood pressure

This drug may cause low blood pressure. Your risk may be higher if you:

  • take water pills
  • eat a low salt diet
  • get dialysis
  • have heart problems
  • get sick with vomiting or diarrhea

Heart attack

Rarely, this drug can increase your risk of severe chest pain that happens often and lasts for a long time. This may raise your risk of having a heart attack. Your risk may be higher if you have severe heart disease.

Drug features

This drug is a prescription drug. It’s available as an oral capsule. 

This drug is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This drug is a combination of two drugs in a single form: amlodipine and benazepril. It is important to know about all the drugs in the combination because they each may have unique traits. 

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

This drug contains two medicines in a single form that work together to lower your blood pressure. This medicine is given only after other medicines haven’t worked.

How it works

Amlodipine belongs to a class of drugs called calcium channel blockers (CCB). Benazepril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.

More Details

How it works

Amlodipine belongs to a class of drugs called calcium channel blockers (CCB). Benazepril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Blood pressure is the force of blood in your blood vessels. High blood pressure occurs when the force is too high. This drug can help your blood vessels relax. This lowers your blood pressure.

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amlodipine-benazepril Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with amlodipine/benazepril include:

  • cough

  • dizziness

  • headache

  • swelling of your feet, ankles, and hands

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • serious allergic reaction. Symptoms include:

    • swelling of your face, eyelids, lips, tongue, or throat
    • trouble swallowing
    • wheezing or other breathing problems
  • low blood pressure (hypotension). Symptoms include:

    • feeling faint or dizzy, especially when you stand up
    • tiredness
    • lightheadedness
  • liver problems. Symptoms include:

    • nausea
    • tiredness
    • weakness
    • itching
    • skin or whites of your eyes that look yellow
    • pain in your upper right stomach
    • flu-like symptoms, such as:
      • fever
      • cough
      • sore throat
      • runny or stuffy nose
      • body aches
      • chills
  • kidney problems. Symptoms include:

    • tiredness
    • swelling, especially of your hands, feet, or ankles
    • shortness of breath
  • chest pain and heart attack

Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug does not cause drowsiness.

This drug may cause low blood pressure. You’re more likely to develop low blood pressure if you:

  • take water pills
  • eat a low salt diet
  • get dialysis
  • have heart problems
  • get sick with vomiting or diarrhea
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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amlodipine-benazepril May Interact with Other Medications

Oral capsule

Amlodipine/benazepril can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Diuretics (water pills)

Taking water pills with amlodipine/benazepril may increase your risk of kidney damage.

Potassium supplements and potassium-sparing diuretics

Taking these medicines with amlodipine/benazepril can increase the potassium in your body.

These drugs include:

  • spironolactone
  • eplerenone
  • amiloride
  • triamterene

Mood stabilizers

Amlodipine/benazepril can increase the levels of these medications. This means that you may have more side effects.

These drugs include:

  • lithium

Cholesterol medications

Amlodipine/benazepril can increase the levels of these medications. This means that you may have more side effects.

These drugs include:

  • simvastatin

Pain medications

Taking certain pain medicines with amlodipine/benazepril can decrease your kidney function.

These drugs include:

  • non-steroidal anti-inflammatory drugs (NSAIDs), such as:
    • ibuprofen
    • naproxen
    • indomethacin
  • COX-2 inhibitors, such as:
    • celecoxib

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver problems

This drug is broken down by your liver. If you have liver problems, more of this drug may stay in your body. This puts you at risk for more side effects. If you have severe liver problems, you may need a lower dose or a different dosing schedule.

People with kidney problems

If you have kidney disease, taking this drug may make your kidney problems worse. Benazepril can cause minor kidney damage. If you already have severe kidney damage (CrCl <30 mL/min), you shouldn’t take this drug.

People with heart problems or chest pain

Rarely, this drug can cause you to have severe chest pain that happens more often or for a longer period of time. Your risk may be higher if you have severe heart disease. This drug may also increase your risk of having a heart attack. If you have heart failure, you may be at a higher risk of kidney failure if you take this medication.

Pregnant women

This drug is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

Tell your doctor if you’re pregnant or plan to become pregnant. If you get pregnant while taking this drug, stop taking it right away. If it’s taken during pregnancy, this drug can harm the developing fetus. It can even be fatal to your unborn baby.

This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are breast-feeding

This drug passes into breast milk and may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors

Older adults may process this drug more slowly. A normal adult dose may cause levels of the drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

For children

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

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How to Take amlodipine-benazepril (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure

Brand: Lotrel

Form: Oral capsule
Strengths:
  • 2.5 mg amlodipine/10 mg benazepril
  • 5 mg amlodipine/10 mg benazepril
  • 5 mg amlodipine/20 mg benazepril
  • 5 mg amlodipine/40 mg benazepril
  • 10 mg amlodipine/20 mg benazepril
  • 10 mg amlodipine/40 mg benazepril

Generic: amlodipine/benazepril

Form: Oral capsule
Strengths:
  • 2.5 mg amlodipine/10 mg benazepril
  • 5 mg amlodipine/10 mg benazepril
  • 5 mg amlodipine/20 mg benazepril
  • 5 mg amlodipine/40 mg benazepril
  • 10 mg amlodipine/20 mg benazepril
  • 10 mg amlodipine/40 mg benazepril
Adult dosage (ages 18–64 years)

The normal adult dose is 2.5 mg amlodipine/10 mg benazepril–10 mg amlodipine/40 mg benazepril. Your doctor may change your dose after 7–14 days based on your blood pressure goals.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Senior dosage (ages 65 years and older)

The recommended dose of amlodipine is 2.5 mg once per day. Your doctor will start you on 2.5 mg amlodipine/10 mg benazepril.

Special considerations

Liver problems: Amlodipine/benazepril is processed by your liver. If you liver isn’t working well, more of the drug may stay in your body longer, putting you at risk for side effects. If you have severe liver problems, your doctor will start you on 2.5 mg amlodipine/10 mg benazepril.

Kidney problems: Your dose of amlodipine/benazepril doesn’t need to be adjusted if you have mild or moderate kidney disease. If you have severe kidney disease, you shouldn’t use this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug comes with serious risks if you don’t take it as prescribed.

What to do if you miss a dose

If you miss a dose, take it as soon as you remember. If it’s been more than 12 hours since you missed a dose, skip the missed dose and just take your next dose at the regular time.

If you skip or miss doses

If you skip or miss doses, your blood pressure may get worse. This could lead to serious problems, such as stroke or heart attack.

If you take too much

You have a higher risk of having side effects caused by this drug. You may also have the following symptoms:

  • trouble breathing
  • very low blood pressure
  • fast heartbeats

If you think that you’ve taken too much of this drug, call your doctor or local poison control center, or go to the nearest emergency room.

How to tell if the drug is working

You’ll know that this drug is working when you check your blood pressure at home. If your blood pressure is at or below the goal your doctor set for you, the medication is working. 

This drug is used for long-term treatment.

This drug must be stored at the right temperature

  • Store this drug at room temperature between 59°F (15°C) and 86°F (30°C).
  • Don’t freeze this drug.
  • Keep this drug away from light.
  • Keep it away from high temperature.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing

Clinical monitoring

During your treatment with this drug, your doctor may check your:

  • blood pressure: You and your doctor should monitor your blood pressure to make sure this drug is working for you.

Your doctor may do these blood tests to decide if this drug is safe for you to start and if you need a lower dose:

  • liver function
  • kidney function and blood urea nitrogen tests to check how well your kidneys are working
  • blood potassium

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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How Much Does amlodipine-benazepril Cost?

Oral capsule

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Lowest price for amlodipine-benazepril

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These prices represent the lowest priced national pharmacies for amlodipine-benazepril on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 31, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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