Amlodipine/atorvastatin | Side Effects, Dosage, Uses & More
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Generic Name:

amlodipine-atorvastatin, Oral tablet

All Brands

  • Caduet
SECTION 1 of 5

Highlights for amlodipine-atorvastatin

Oral tablet
1

Amlodipine/atorvastatin is an oral drug that’s used to treat people who have high blood pressure (hypertension) along with one of two other conditions: dyslipidemia (abnormal lipid levels) or coronary artery disease. It is also used to help prevent cardiovascular disease.

2

Common side effects include swelling of your legs or ankles, diarrhea, nausea, upset stomach, and muscle and joint pain.

3

Amlodipine/atorvastatin can cause serious muscle problems that can lead to kidney problems, including kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, and a fever or tiredness.

4

Amlodipine/atorvastatin can harm your unborn child. You shouldn’t try to get pregnant while you’re taking this drug. If you become pregnant, stop taking this drug right away and call your doctor. You also shouldn’t breastfeed your child while taking this medicine.

IMPORTANT INFORMATION

Liver problems

This drug can cause liver problems. You shouldn’t take this drug if you already have active liver problems. Call your doctor right away if you have any of these symptoms:

  • tiredness or weakness
  • loss of appetite
  • upper stomach pain
  • dark-colored urine
  • yellowing of your skin or the whites of your eyes

Muscle pain

This drug can cause serious muscle problems that can lead to kidney problems and kidney failure. You have a higher chance for muscle problems if you’re taking certain medications that block its metabolism. These drugs include:

  • clarithromycin
  • erythromycin
  • telithromycin
  • gemfibrozil
  • niacin
  • boceprevir
  • darunavir
  • fosamprenavi
  • lopinavir/ritonavir
  • nelfinavir
  • indinavir
  • ritonavir
  • saquinavir
  • telaprevir
  • tipranavir
  • delavirdine
  • efavirenz
  • nevirapine
  • tacrolimus
  • conivaptan
  • diltiazem
  • verapamil
  • nefazodone
  • mifepristone
  • amiodarone
  • fluconazole
  • itraconazole
  • ketoconazole
  • colchicine
  • cyclosporine
  • daptomycin

Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, and a fever or tiredness.

Heart problems

This drug can increase your risk of developing heart disease. It can also cause low blood pressure, new or worse chest pain, or a heart attack. This is most likely to occur after dose increases.

Drug features

This drug is a prescription drug. It’s available as an oral tablet.

This drug is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This drug is a combination of two drugs in a single form. It is important to know about all the drugs in the combination because they each may have unique traits.

Why it's used

This drug is used to lower blood pressure and cholesterol levels. This drug also helps blood flow better to your heart when your arteries (blood vessels in your heart) are blocked.

How it works

This drug is a combination of two drugs in a single form: amlodipine and atorvastatin. Amlodipine belongs to a class of drugs called calcium channel blockers.

More Details

How it works

This drug is a combination of two drugs in a single form: amlodipine and atorvastatin. Amlodipine belongs to a class of drugs called calcium channel blockers. Atorvastatin belongs to a class of drugs known as HMG CoA-reductase inhibitors (or statins). A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Amlodipine relaxes your blood vessels so that blood can flow more easily to your heart. This helps lower your blood pressure. Atorvastatin blocks an enzyme known as HMG Co-A reductase. This helps lower your cholesterol levels. These actions together reduce your risk for stroke, coronary artery disease, and certain types of heart surgery.

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SECTION 2 of 5

amlodipine-atorvastatin Side Effects

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More Common Side Effects

The most common side effects that occur with amlodipine/atorvastatin include:

  • swelling of your legs or ankles

  • diarrhea

  • nausea

  • upset stomach

  • muscle and joint pain

  • liver test changes

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • muscle tissue problems. Symptoms include:

    • muscle weakness, tenderness, or pain that happens for no reason, along with:
      • a fever
      • feeling more tired than usual
    • muscle problems that don’t go away even after your doctor tells you to stop taking this drug
  • liver problems. Symptoms include:

    • tiredness or weakness
    • loss of appetite
    • upper stomach pain
    • dark-colored urine
    • yellowing of your skin or the whites of your eyes
  • low blood pressure or dizziness

  • chest pain that doesn't go away or get worse

Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

amlodipine-atorvastatin May Interact with Other Medications

Oral tablet

medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Food interactions

Red yeast grapefruit juice can increase the level of this drug in your body. This can lead to more side effects, such as severe muscle pains or weakness.

Alcohol interaction

The use of drinks that contain alcohol can increase your risk of low blood pressure. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Erection problems medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can increase your risk for side effects.

These drugs include:

  • sildenafil
  • tadalafil
  • vardenafil

Heart problems medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can cause more side effects.

These drugs include:

  • diltiazem
  • verapamil

Antifungal medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can cause more side effects.

These drugs include:

  • ketoconazole
  • itraconazole
  • voriconazole
  • fluconazole

Antibiotics

These drugs can increase the level of amlodipine/atorvastatin in your body. This can cause more side effects.

These drugs include:

  • clarithromycin
  • erythromycin
  • telithromycin

Depression medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can cause more side effects.

These drugs include:

  • nefazodone

Human immunodeficiency virus (HIV) medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can cause more side effects.

These drugs include:

  • ritonavir
  • saquinavir
  • darunavir
  • fosamprenavir
  • nelfinavir
  • efavirenz
  • lopinavir
  • telaprevir
  • tipranavir
  • delavirdine
  • efavirenz
  • indinavir

Seizure medications

These medicines can decrease or increase the level of amlodipine/atorvastatin in your body. This means that it may not work as well.

These drugs include:

  • carbamazepine
  • phenobarbital
  • primidone
  • phenytoin

Tuberculosis medications

These medicines can lower the level of amlodipine/atorvastatin in your body. This means that it may not work as well.

These drugs include:

  • rifampin
  • rifabutin

Medications that weaken your immune system

Amlodipine/atorvastatin may cause levels of these medications to increase in your body. This may lead to more side effects.

These drugs include:

  • cyclosporine
  • tacrolimus

Cholesterol medications

These drugs can increase the level of amlodipine/atorvastatin in your body. This can lead to more side effects.

These drugs include:

  • fenofibrate
  • gemfibrozil
  • niacin (if your dose is greater than 1 g)

 

Hepatitis C virus infection drugs

These drugs can increase the level of amlodipine/atorvastatin in your body. This can lead to more side effects.

These drugs include:

  • telaprevir
  • boceprevir

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver disease

Atorvastatin may cause liver problems or make existing liver problems worse. If you have chronic alcoholic liver disease, the levels of this drug may increase in your body. This could lead to more side effects. Your doctor may do blood tests before and during treatment to make sure this drug is safe for you. You shouldn’t take this drug if you have active liver problems.

People with diabetes

Atorvastatin may increase your blood sugar levels.

People with heart disease

If you have heart disease, this drug can cause low blood pressure, new or worse chest pain, or a heart attack. This is most likely to occur after dose increases. If this happens, call your doctor or go to the emergency room right away.

Pregnant women

This drug is a category X pregnancy drug. Category X drugs should never be used during pregnancy.

Women who are breast-feeding

This drug may pass into breast milk and may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors

You may be started at a lower dose to make sure you don’t receive too much of the drug.

For children

It isn’t known if this drug is safe and effective in males younger than 18 years or females younger than 10 years.

This medication may be used in females aged 10­–17 for the treatment of high blood pressure and high cholesterol.  

When to call the doctor

Call your doctor if you become pregnant while taking this drug.

Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing or swallowing
  • swelling of your face, lips, tongue, or throat
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

SECTION 4 of 5

How to Take amlodipine-atorvastatin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension and dyslipidemia

Brand: Caduet

Form: Oral tablet
Strengths: 
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin

Generic: amlodipine/atorvastatin

Form: Oral tablet
Strengths:  
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin
Adult dosage (ages 18–64 years)
  • Your doctor will determine the dose combination that is appropriate for you and your treatment goals.
  • The typical starting dose is between 5 mg amlodipine/10 mg atorvastatin and 5 mg amlodipine/20 mg atorvastatin.
  • The maximum dose per day is 10 mg amlodipine/80 mg atorvastatin.
Child dosage (ages 0–17 years)

It is unknown if the combination drug amlodipine/atorvastatin is safe and effective for children younger than 18 years. However, there are safe dosing recommendations for children for each drug when given separately. Talk to your doctor about what dose is appropriate for your child.

Senior dosage (ages 65 years and older)

It isn’t known if amlodipine/atorvastatin is safe and effective for adults aged 65 years and older. Older adults may process drugs more slowly. A normal adult dose may cause levels of amlodipine/atorvastatin to be higher than normal. If you’re a senior, you may need a lower dose.

Coronary artery disease and hypertension

Brand: Caduet

Form: Oral tablet
Strengths: 
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin

Generic: amlodipine/atorvastatin

Form: Oral tablet
Strengths:  
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin
Adult dosage (ages 18–64 years)
  • Your doctor will determine the dose combination that is appropriate for you and your treatment goals.
  • The typical starting dose is between 5 mg amlodipine/10 mg atorvastatin and 5 mg amlodipine/20 mg atorvastatin.
  • The maximum dose per day is 10 mg amlodipine/80 mg atorvastatin.
Child dosage (ages 0–17 years)

It is unknown if the combination drug amlodipine/atorvastatin is safe and effective for children younger than 18 years. However, there are safe dosing recommendations for children for each drug when given separately. Talk to your doctor about what dose is appropriate for your child.

Senior dosage (ages 65 years and older)

It isn’t known if amlodipine/atorvastatin is safe and effective for adults aged 65 years and older. Older adults may process drugs more slowly. A normal adult dose may cause levels of amlodipine/atorvastatin to be higher than normal. If you’re a senior, you may need a lower dose.

Prevention of cardiovascular disease

Brand: Caduet

Form: Oral tablet
Strengths: 
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin

Generic: amlodipine/atorvastatin

Form: Oral tablet
Strengths:  
  • 2.5 mg amlodipine/10 mg atorvastatin
  • 2.5 mg amlodipine/20 mg atorvastatin
  • 2.5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/10 mg atorvastatin
  • 5 mg amlodipine/20 mg atorvastatin
  • 5 mg amlodipine/40 mg atorvastatin
  • 5 mg amlodipine/80 mg atorvastatin
  • 10 mg amlodipine/10 mg atorvastatin
  • 10 mg amlodipine/20 mg atorvastatin
  • 10 mg amlodipine/40 mg atorvastatin
  • 10 mg amlodipine/80 mg atorvastatin
Adult dosage (ages 18–64 years)
  • Your doctor will determine the dose combination that is appropriate for you and your treatment goals.
  • The typical starting dose is between 5 mg amlodipine/10 mg atorvastatin and 5 mg amlodipine/20 mg atorvastatin.
  • The maximum dose per day is 10 mg amlodipine/80 mg atorvastatin.
Child dosage (ages 0–17 years)

It is unknown if the combination drug amlodipine/atorvastatin is safe and effective for children younger than 18 years. However, there are safe dosing recommendations for children for each drug when given separately. Talk to your doctor about what dose is appropriate for your child.

Senior dosage (ages 65 years and older)

It isn’t known if amlodipine/atorvastatin is safe and effective for adults aged 65 years and older. Older adults may process drugs more slowly. A normal adult dose may cause levels of amlodipine/atorvastatin to be higher than normal. If you’re a senior, you may need a lower dose.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all or stop taking it

If you don’t take this drug at all or stop taking it, you raise your risk for severe heart problems, such as a stroke or heart attack.

If you skip or miss doses

If you miss doses, you raise your risk for more severe heart problems, such as a stroke or heart attack.

What to do if you miss a dose

If you miss a dose, take it as soon as you remember. Don’t take this drug if it’s been more than 12 hours since your missed dose. Just take the next dose at your regular time. Do not take two doses at the same time.

If you take too much

If you take too much of this drug, you may have these symptoms:

  • dangerously low blood pressure. Symptoms include:
    • dizziness
    • lightheadedness
    • fainting
  • a very fast heart rate
  • shock

If you think that you’ve taken take too much, call your doctor or poison control center, or go to the emergency room.

How to tell this drug is working

You may be able to tell if this drug is working if your blood pressure and cholesterol levels decrease.

If you’re taking this drug for heart disease, you won’t be able to feel if this drug is working. But it’s important to continue taking it as directed by your doctor. This will decrease your risk of hospitalization from chest pain and possibly needing heart surgeries. Your cholesterol levels will also decrease.

This drug is used for long-term treatment.

Don’t cut or crush the tablets before taking them

Talk to your doctor if you have problems swallowing pills.

This drug must be stored at the right temperature

  • Store Caduet at room temperature. Keep it from 59°F (15°C) to 86°F (30°C). Store generic amlodipine/atorvastatin tablets between 68°F (20°C) and 77°F (25°C). Keep it away from high temperature.
  • Store this drug in its original container. Keep it tightly closed.
  • Keep this drug away from light.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.

Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Before starting and during your treatment with this drug, your doctor may check the following:

  • liver function: Your doctor may do blood tests to make sure your liver is working well and that this drug is safe for you to take.
  • cholesterol levels: Your doctor may do blood tests to make sure that this drug is lowering your cholesterol levels.
  • blood pressure: Your doctor may check your blood pressure to make sure that this drug is working for you.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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SECTION 5 of 5

How Much Does amlodipine-atorvastatin Cost?

Oral tablet

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

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Lowest price for amlodipine-atorvastatin

Walgreens $112.41
CVS Pharmacy $112.59
Rite-Aid $119.96
These prices represent the lowest priced national pharmacies for amlodipine-atorvastatin on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for amlodipine-atorvastatin on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 28, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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