Chlordiazepoxide/amitriptyline | Side Effects, Dosage, Uses & More
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Generic Name:

amitriptyline-chlordiazepoxide, Oral tablet

All Brands

  • Limbitrol DS (Discontinued)
  • Limbitrol
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
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Highlights for amitriptyline-chlordiazepoxide

Oral tablet
1

Chlordiazepoxide/amitriptyline is a combination of two drugs in a single form. It’s used to treat people who have both depression and anxiety at the same time.

2

This drug comes in the form of a tablet you take by mouth.

3

Chlordiazepoxide/amitriptyline is only available as a generic drug.

4

The more common side effects of this drug include dizziness, dry mouth, constipation, and blurred vision.

5

In some cases, chlordiazepoxide/amitriptyline can cause serious side effects. These include worsening of depression symptoms, suicidal thoughts (thoughts of harming yourself), and unusual changes in behavior. This is more likely to happen during the first few months of treatment with this drug.

IMPORTANT INFORMATION

FDA warning

This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.

Suicidal thinking and behavior warning. This drug can increase the risk of suicidal thinking and behavior (thoughts and actions of harming yourself) in children, adolescents, and young adults. When you first start taking this drug, your doctor and family should watch you closely. They should look for changes in your behavior or worsening signs of depression.

Initial worsening of depression

You may have worse depression symptoms, suicidal thoughts (thoughts of harming yourself), and changes in behavior when you first start taking this drug. You may continue to have these symptoms until the drug starts working for you. This may take up to a few weeks.

Withdrawal symptoms

You shouldn’t stop taking this drug without talking to your doctor. If you stop taking it suddenly, you may have withdrawal symptoms. These include tremors (uncontrollable rhythmic movements in one part of your body), stomach pains, sweating, and headaches. Your risk is higher if you’ve taken this drug for a long time. If you need to stop taking this drug, your doctor will slowly lower your dose.

Drug features

Chlordiazepoxide/amitriptyline is a prescription drug. It’s available as an oral tablet.

Chlordiazepoxide/amitriptyline is only available as a generic drug.

Chlordiazepoxide/amitriptyline is a combination drug. It contains two drugs: chlordiazepoxide and amitriptyline. It’s important to know about both drugs in the combination because each drug may affect you in a different way.

Why it’s used

Chlordiazepoxide/amitriptyline is used to treat people who have both depression and anxiety at the same time.

How it works

Chlordiazepoxide belongs to a class of drugs called benzodiazepines.

More Details

How it works

Chlordiazepoxide belongs to a class of drugs called benzodiazepines. Amitriptyline belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Chlordiazepoxide/amitriptyline works on your central nervous system. It increases the level of certain chemicals in your brain. This improves your symptoms of depression and anxiety.

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amitriptyline-chlordiazepoxide Side Effects

Oral tablet

More common side effects

The more common side effects of chlordiazepoxide/amitriptyline can include:

  • drowsiness

  • dry mouth

  • constipation

  • blurred vision

  • dizziness

  • bloating

  • vivid dreams

  • tremors (uncontrollable rhythmic movements in one part of your body)

  • erectile dysfunction (trouble getting or keeping an erection)

  • confusion

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Heart attack. Symptoms can include:

    • chest pain
    • shortness of breath
    • discomfort in your upper body
  • Stroke. Symptoms can include:

    • weakness in one part or side of your body
    • slurred speech
  • Worsening symptoms of depression and suicidal thoughts (thoughts of harming yourself)

Pharmacist's Advice
Healthline Pharmacist Editorial Team
Chlordiazepoxide/amitriptyline may cause dizziness and drowsiness during the first few hours after you take it.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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amitriptyline-chlordiazepoxide May Interact with Other Medications

Oral tablet

Chlordiazepoxide/amitriptyline can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

The use of drinks that contain alcohol can increase your risk of sedation and drowsiness to dangerous levels from this drug. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Drugs you should not use with chlordiazepoxide/amitriptyline

Don’t take these drugs with chlordiazepoxide/amitriptyline. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Phenelzine, tranylcypromine, and selegiline. Taking these drugs together may lead to convulsions (violent, involuntary movements) and a dangerously high fever. It may even be fatal (cause death).
  • Flecainide and propafenone. Taking these drugs together could increase your risk of irregular heart rate.
  • Sertraline, fluoxetine, and paroxetine. Taking these drugs together can increase the side effects of chlordiazepoxide/amitriptyline. These can include dizziness, confusion, and heart attack.
  • Cimetidine and quinidine. These drugs could increase the amount of the amitriptyline in your body. This could lead to dangerous side effects. These can include dizziness, confusion, and heart attack.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Chlordiazepoxide/amitriptyline warnings
People with a history of heart problems
People with a history of heart problems

This drug could cause heart problems. These include irregular heart rate, heart attack, and stroke. You shouldn’t take chlordiazepoxide/amitriptyline if you’ve had a recent heart attack.

People with a history of bipolar disorder
People with a history of bipolar disorder

This drug shouldn’t be used to treat bipolar disorder. Taking antidepressants, such as chlordiazepoxide/amitriptyline, can cause people with bipolar to switch from depression to a manic phase. You should use other drugs called mood stabilizers instead of antidepressants.

People with a history of seizures
People with a history of seizures

This drug may increase your risk of seizures.

People with a history of glaucoma or increased eye pressure
People with a history of glaucoma or increased eye pressure

This drug may make your condition worse.

People with a thyroid condition
People with a thyroid condition

Thyroid drugs may increase the side effects of chlordiazepoxide/amitriptyline.

Pregnant women
Pregnant women

Amitriptyline is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

Chlordiazepoxide is a category D pregnancy drug. This means:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

Women who are breast-feeding
Women who are breast-feeding

Chlordiazepoxide/amitriptyline may pass into breast milk and may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your child. You may need to decide whether to stop breast-feeding or stop taking this medication.

For seniors
For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

If you’re over the age of 65 years, you may be at a higher risk of confusion and sedating side effects from this drug.

For children
For children

This medication hasn’t been studied in children.

When to call the doctor
When to call the doctor

Call your doctor right away if you become pregnant while taking this drug.

Call your doctor if your depression gets worse of if you have thoughts of suicide (harming yourself).

Allergies
Allergies

Chlordiazepoxide/amitriptyline can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take amitriptyline-chlordiazepoxide (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Depression and anxiety together

Generic: chlordiazepoxide/amitriptyline

Form: Oral tablet
Strengths: 5 mg chlordiazepoxide/12.5 mg amitriptyline, 10mg chlordiazepoxide/25mg amitriptyline
Adult dosage (ages 18–64 years)
  • Typical starting dose: 3–4 tablets (of either strength of the drug) per day taken in divided doses.
  • Dose increases: Your doctor may slowly increase your dose up to 6 tablets (of either strength of the drug) per day taken in divided doses.
Child dosage (ages 0–17 years)

This medication hasn’t been studied in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Chlordiazepoxide/amitriptyline comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

If you don’t take this drug, your depression and anxiety may get worse. If you stop taking this drug suddenly, you may have withdrawal symptoms. These include tremors (uncontrollable rhythmic movements in one part of your body), stomach pains, sweating, and headaches. If you need to stop taking this drug, your doctor will slowly lower your dose.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • irregular heart rate
  • very low heart rate
  • convulsions (violent, involuntary movements)
  • hallucinations (seeing or hearing something that isn’t there)
  • confusion
  • stiff muscles

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your symptoms of depression and anxiety should get better over time.

Chlordiazepoxide/amitriptyline is used for long-term treatment.

Important considerations for taking chlordiazepoxide/amitriptyline
You can take chlordiazepoxide/amitriptyline with or without food
You can take chlordiazepoxide/amitriptyline with or without food
Take this drug at the time(s) recommended by your doctor
Take this drug at the time(s) recommended by your doctor
You can cut or crush the tablet
You can cut or crush the tablet
Store this drug carefully
Store this drug carefully
See Details
A prescription for this medication is refillable
A prescription for this medication is refillable
See Details
Travel
Travel
See Details
Clinical monitoring
Clinical monitoring
See Details

Store this drug carefully

  • Store chlordiazepoxide/amitriptyline at room temperature. Keep it between 59°F and 86°F (15°C and 30°C).
  • Keep it away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Mental health and behavioral problems. You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems. It may also make problems you already have worse.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on November 27, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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