Generic Name:

alosetron, Oral tablet

All Brands

  • Lotronex
SECTION 1 of 5

Highlights for alosetron

Oral tablet
ALOSETRON (al OH se tron) is used to treat irritable bowel syndrome (IBS) in women. It is reserved for those women who have severe diarrhea as the main symptom and who have not had success with other treatments. This medicine has not been shown to work in men with IBS. It is available only from health care providers who participate in a special Prescribing Program because this drug may cause serious side effects. Your health care provider will discuss your condition and these side effects with you prior to prescribing this drug.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 5

alosetron Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional immediately:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blood in stool, bloody diarrhea or rectal bleeding
  • constipation
  • dark urine
  • hemorrhoids
  • fever
  • irregular heart beat
  • unusually weak or tired
  • worsening of abdominal pain
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • anxiety
  • difficulty sleeping
  • dry mouth
  • frequent urination
  • gas
  • headache
  • nausea
  • restlessness
SECTION 3 of 5

alosetron May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • antidiarrheal medicines, like Imodium, Kaopectate, or Lomotil
  • enoxacin
  • fluvoxamine
  • mexiletine
  • zileuton

This medicine may also interact with the following medications:

  • certain antibiotics like ciprofloxacin, clarithromycin, erythromycin or troleandomycin
  • cimetidine
  • hydralazine
  • isoniazid, INH
  • medicines for fungal infections like ketoconazole, itraconazole and voriconazole
  • medicines for HIV or AIDS
  • procainamide
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 5

How to Use alosetron

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine is not for use in children.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • constipation
  • Crohn's disease
  • diverticulitis
  • history of ischemic colitis, impaired intestinal circulation, bleeding, or blood clots
  • history of a stomach, bowel, or intestine problems
  • kidney disease or liver disease
  • toxic megacolon
  • ulcerative colitis
  • an unusual or allergic reaction to alosetron, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, skip that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Constipation is a common and serious side effect of this medicine. Stop taking this medicine and call your health care provider immediately if you become constipated. Only restart this medicine if your constipation has resolved and you and your doctor have agreed to restart treatment. You should not start taking this medicine if you are already constipated or constipated most of the time.

Ischemic colitis is a serious and potentially life-threatening condition that has been rarely reported with this medicine. If you experience new or worsening abdominal pain, bloody diarrhea or blood in the stool, immediately stop taking this medicine and contact your doctor or health care professional.

This medicine may not work for all women who take it. For women who are helped by this medicine, relief may occur within the first week or within four weeks of starting the drug. If you stop taking this medicine, it is likely that your symptoms will return within one week.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Alcohol can increase drowsiness or dizziness. Avoid alcoholic drinks.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

What does the pill look like?

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SECTION 5 of 5

How Much Does alosetron Cost?

Oral tablet

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

Compare prices and save up to 80% on your next refill!

Lowest price for alosetron

Walgreens $340.37
Rite-Aid $360.86
CVS Pharmacy $625.88
These prices represent the lowest priced national pharmacies for alosetron on GoodRx. They may be lower than your insurance.

Enter your zip code to find the best deal near you.

These prices represent the lowest priced national pharmacies for alosetron on GoodRx. They may be lower than your insurance.

Last Updated: June 30, 2014

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