Generic Name: alogliptin, Oral tablet

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SECTION 1 of 5

Highlights for alogliptin

Oral tablet
1

Alogliptin is used along with diet and exercise to help lower blood sugar levels in people with type 2 diabetes.

2

Common side effects include headaches, upper respiratory infection, and the common cold.

3

Alogliptin may cause liver damage or inflammation of the pancreas (pancreatitis) in some patients.

4

Don’t use alogliptin if you have type 1 diabetes or increased ketones in your urine or blood.

5

Alogliptin helps your body to release more insulin to help lower your blood sugar levels.

IMPORTANT INFORMATION

Serious allergic reaction

Alogliptin may cause a serious allergic reaction, such as swelling of your face, lips, or throat, difficulty swallowing or breathing, hives, or skin rash.

Liver damage

Alogliptin may cause liver damage. Your doctor will test your liver function before you start this medication. Tell your doctor right away if you have pain in the upper right part of your abdomen, dark urine, yellowing of your skin, decreased appetite, and tiredness.

Pancreatitis

Alogliptin may cause a sudden inflammation of your pancreas (pancreatitis). Tell your doctor right away if you have severe stomach pain that travels to your back, a swollen or tender stomach, or nausea or vomiting.

Drug Features

Alogliptin is a prescription drug. It’s available as an oral tablet.

Alogliptin may be used as part of a combination therapy. That means you may need to take it with other drugs.

Why It's Used

Alogliptin is used along with diet and exercise to manage high sugar levels caused by type 2 diabetes.

How It Works

Alogliptin belongs to a class of drugs called DPP-4 inhibitors.

More Details

How It Works

Alogliptin belongs to a class of drugs called DPP-4 inhibitors. A class of drugs refers to medications that work similarly. They are often used to treat similar conditions.

Normally as you start to eat, hormones are released into your bloodstream. They cause insulin to be released into your bloodstream, which helps pick up and store the carbohydrates and sugar from the meal. Alogliptin helps these hormones to continue the release of insulin to help lower your blood sugar levels.

SECTION 2 of 5

alogliptin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with alogliptin include:

  • stuffy or runny nose and sore throat

  • headache

  • cold-like symptoms

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms may include:

    • swelling of face, lips, throat
    • difficulty swallowing or breathing
    • skin rash
    • hives
    • itching
    • peeling or flaking of your skin
  • liver damage. Symptoms may include:

    • dark urine
    • yellowing of your skin or the whites of your eyes
    • nausea and vomiting
    • stomach pain
    • loss of appetite
    • unusual tiredness
  • blood sugar level that is too low (hypoglycemia). Symptoms may include:

    • shaking or feeling jittery
    • sweating
    • fast heartbeat
    • change in vision
    • dizziness
  • inflammation of the pancreas (pancreatitis). Symptoms may include:

    • sudden pain in stomach that travels to your back
    • swollen and tender stomach
    • nausea or vomiting
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Alogliptin does not cause drowsiness.

Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

alogliptin May Interact with Other Medications

Oral tablet

Alogliptin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Alcohol may affect your blood sugar level. It may increase the risk of low blood sugar (hypoglycemia). It may also increase your blood sugar levels by serving as an additional source of carbohydrates. Talk with your doctor before drinking alcohol.

Medications That Might Interact with This Drug

Certain blood pressure drugs

Examples are:

  • benazepril
  • captopril
  • enalapril
  • fosinopril
  • quinapril
  • ramipril

Alogliptin may increase the toxic effects of these drugs by increasing the risk for an allergic reaction. Taking this class of blood pressure medications with alogliptin may also increase your risk for low blood sugar.

Hormones
  • androgens
  • pegvisomant
  • somatropin

Taking these drugs with alogliptin may affect your blood sugar levels. Androgens may raise or lower blood sugar. Taking pegvisomant with alogliptin may lower your blood sugar and result in hypoglycemia. Your doctor will adjust your diabetes medications, as needed.

Corticosteroids
  • prednisone or prednisolone
  • hydrocortisone
  • methylprednisolone

These drugs may increase blood sugar levels. Taking these medications with alogliptin may result in loss of blood glucose control.

Blood pressure drugs
  • chlorthalidone
  • hydrochlorothiazide
  • triamterene

These drugs may increase your blood sugar. Your doctor will adjust your diabetes medications, as needed.

Other diabetes drugs
  • insulin
  • sulfonylureas: glipizide, glimepiride, glyburide, chlorpropamide
  • meglitinides: repaglinide (Prandin), nateglinide (Starlix)

Taking alogliptin with these drugs may lead to low blood sugar levels. Your doctor may need to lower the dose of insulin or the oral drug.

Antibiotics known as fluoroquinolones
  • gatifloxacin
  • levofloxacin
  • moxifloxacin
  • ciprofloxacin

Taking alogliptin with these medications may cause increases or decreases in blood sugar levels (hyperglycemia or hypoglycemia). Do not take gatifloxacin with alogliptin. It may cause serious changes in blood sugar levels. Your doctor will need to monitor blood glucose levels closely if you’re taking other fluoroquinolones in combination with alogliptin.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with kidney disease

Your doctor may reduce your dose of alogliptin if you have kidney disease. This may cause too much alogliptin to build up in your body if you take it at the usual dose. Too much of this drug in your body can lower your blood sugar level too much.

People with pancreatitis

Alogliptin may cause or worsen this condition. Other drugs should be used.

People with liver failure

Alogliptin may cause or worsen this condition. Other drugs should be used.

Pregnant women

Alogliptin is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals have not shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Speak with your doctor if you’re pregnant or planning to become pregnant. Alogliptin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

It isn’t known if alogliptin passes through breast milk. You and your doctor need to decide if you’ll take alogliptin or breastfeed.

For Children

The safety and effectiveness of alogliptin in people under 18 years old have not been established.

Allergies

Alogliptin may cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
  • itching
  • peeling or flaking of your skin

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take alogliptin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strengths: 6.25 mg, 12.5 mg, and 25 mg
Adult Dosage (ages 18 years and older)

The recommended dosage is 25 mg once per day.

Child Dosage (ages 0-17 years)

Dosage in people younger than 18 years has not been established.

Special Considerations

Kidney disease: Your doctor may reduce your dose of alogliptin if you have kidney disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Alogliptin won’t cause drowsiness.

If You Don’t Take It at All

Your blood sugar levels may increase, and your diabetes may get worse.

If You Skip or Miss Doses

If you take too much or think you may have taken too much, contact a poison control center or go to the emergency room immediately. Your blood sugar level may get too low.

If You Take Too Much

If you take too much or think you may have taken too much, contact a poison control center or go to the emergency room immediately. Your blood sugar level may get too low.

What to Do If You Miss a Dose

If you forget to take your dose, take it as soon as you remember, unless you remember just a few hours before the time for your next dose. Then take only one dose.

Never try to catch up by taking two tablets at once. This could result in toxic side effects.

How to Tell If the Drug Is Working

If this drug is working, your blood sugar levels will decrease.

Alogliptin is a long-term drug treatment.

Important Considerations for Taking Alogliptin
take with or without food Alogliptin may be taken with or without food
do not crush Do not crush, chew, or break the tablet
storage Store alogliptin at room temperature See Details
refillable Prescription is refillable
travel Travel See Details
clinical monitoring Clinical Monitoring See Details
not usually stocked Not every pharmacy stocks this drug, so call ahead
prior authorization needed Insurance See Details

Store alogliptin at room temperature

Keep in temperatures between 68°F to 77°F (20°C to 25°C).

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.
  • Do not put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical Monitoring

Your doctor will test your blood sugar levels and your A1c levels to make sure that the drug is keeping your diabetes under control.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for alogliptin.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does alogliptin Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

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Lowest price for alogliptin

Membership warehouse $323.19
Kroger Pharmacy $324.43
Publix $324.43
These represent the lowest cash prices for alogliptin and may be lower than your insurance.

Find the lowest prices of alogliptin near you

These represent the lowest cash prices for alogliptin and may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 25, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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