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Generic Name:

alogliptin-pioglitazone, Oral tablet

All Brands

  • Oseni
SECTION 1 of 4

Highlights for alogliptin-pioglitazone

Oral tablet
1

Alogliptin/pioglitazone is a combination of two drugs in a single form used to help lower and control blood sugar levels in people who have type 2 diabetes. It’s taken in addition to diet and exercise. Sometimes it’s taken with other medications used to treat diabetes.

2

Your dose depends on your age and your other health conditions.

3

The most common side effects that may occur with alogliptin/pioglitazone are stuffy or runny nose and sore throat, back pain, and cold-like symptoms (upper respiratory tract infection).

4

Pioglitazone, one of the medications in Oseni, may cause or worsen a heart condition known as congestive heart failure, in which your heart doesn’t pump blood well enough. Other medications used to treat diabetes, such as insulin and sulfonylureas (which help your pancreas make more insulin), can lower your blood sugar. When these drugs are taken together with alogliptin/pioglitazone, you may have a greater chance of your blood sugar levels becoming too low.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Congestive heart failure. Pioglitazone, one of the medications in Oseni, can cause or worsen a heart condition known as congestive heart failure, in which your heart doesn’t pump blood well enough. Your risk may be higher if you already have heart or kidney problems. Your doctor will monitor you for symptoms of heart failure such as unusually fast weight gain, trouble breathing, or swelling. If heart failure develops, your doctor may lower your dose or stop this medication.

This drug isn’t recommended if you have symptoms of heart failure (unusually fast weight gain, trouble breathing, or swelling).

If you have severe heart failure (New York Heart Association Class 3 or 4), don’t take alogliptin/pioglitazone. It may worsen your condition.

Bladder cancer

If you have active bladder cancer or history of bladder cancer, don’t use this drug. It’s unknown if this medication could worsen cancer or cause the cancer to return.

Pancreatitis (inflammation of the pancreas)

One of the medications in this drug, alogliptin, may cause pancreatitis. Tell your doctor right away if you have severe stomach pain, stomach pain that travels to your back, a swollen or tender stomach, or nausea/vomiting.

Liver damage

This medication may cause liver damage. Tell your doctor right away if you have pain in the upper right part of your abdomen, dark urine, yellowing of your skin, decreased appetite, and tiredness. These may be signs of liver problems. Your doctor may want to do a blood test to check your liver function.

What is alogliptin-pioglitazone?

This drug is a prescription drug. It’s available as an oral tablet.

This is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

Why it's used

This drug is used to help lower and control blood sugar levels in people who have type 2 diabetes. It’s used in addition to diet and exercise and may be taken with other diabetes medications.

How it works

Alogliptin belongs to a class of drugs called dipeptidyl peptidase-4 inhibitors, and pioglitazone belongs to a class of drugs called thiazolidinediones.

More Details

How it works

Alogliptin belongs to a class of drugs called dipeptidyl peptidase-4 inhibitors, and pioglitazone belongs to a class of drugs called thiazolidinediones. A class of drugs refers to medications that work similarly. They’re often used to treat similar conditions. Both medications work on certain hormones and cells in your body to help lower your blood sugar levels.

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SECTION 2 of 4

alogliptin-pioglitazone Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with alogliptin/pioglitazone include:

  • stuffy or runny nose and sore throat

  • back pain

  • cold-like symptoms (upper respiratory tract infection)

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • heart failure. Symptoms may include:

    • fast increase in weight
    • trouble breathing or shortness of breath, especially when you lie down
    • swelling in your ankles or legs
    • unusual tiredness
  • pancreatitis. Symptoms may include:

    • a severe pain in your stomach that doesn’t go away
    • stomach pain that travels to your back
    • vomiting
  • liver damage. Symptoms may include:

    • tiredness
    • loss of appetite
    • stomach pain
    • dark urine
    • yellowing of your skin or the whites of your eyes
    • nausea/vomiting
  • broken bones

  • eye problems. Symptoms may include:

    • any changes in vision
  • Blood sugar level that is too low (hypoglycemia). Symptoms may include:

    • shaking or feeling jittery
    • sweating
    • fast heartbeat
    • change in vision
    • dizziness
    • headache
  • Bladder cancer. Symptoms may include:

    • blood or a red color in your urine
    • needing to urinate more than normal
    • pain with urination
  • severe joint pain

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Mild side effects may disappear within a few days or a couple of weeks. If they’re more severe or don’t go away talk to you doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

alogliptin-pioglitazone May Interact with Other Medications

Oral tablet

Alogliptin/pioglitazone can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Medications that strongly inhibit the liver enzyme CYP2C8
  • Cholesterol drug: gemfibrozil
  • Blood thinning drug: clopidogrel

Taking these drugs with alogliptin/pioglitazone can increase the amount of pioglitazone in your body and lead to greater side effects. Use a maximum of 15 mg per day of pioglitazone in this situation with either of these drugs.

Tuberculosis drug
  • rifampin

When taking this drug with alogliptin/pioglitazone, the amount of pioglitazone in your body may decrease, making it less effective. Your doctor may need to change your dose of pioglitazone if you take this drug.

Other diabetes drugs
  • insulin
  • sulfonylureas, such as:
    • glipizide
    • glimepiride
    • glyburide
    • chlorpropamide

When these drugs are taken together with alogliptin/pioglitazone, you may have a greater chance of your blood sugar being too low. Your doctor may need to lower your dose of these drugs. Also, the combination of insulin and pioglitazone (one of the medications in this drug) increases the risk of heart failure and swelling. Use caution if this medication is taken with insulin.

Class of antibiotics known as fluoroquinolones
  • gatifloxacin
  • levofloxacin
  • moxifloxacin
  • ciprofloxacin

When taking these medications with alogliptin/pioglitazone, increases or decreases in blood sugar levels (hyperglycemia or hypoglycemia) can occur. Don’t take gatifloxain in combination with this medication. It may cause serious changes in blood sugar levels. For the other fluoroquinolones, monitor blood glucose levels closely while taking these drugs in combination.

Heart medication
  • ivabradine

Taking ivabradine in combination with this medication could cause lower levels of ivabradine in your body. This may result in ivabradine not working for your heart condition as it’s supposed to.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
cardiovascular system icon
People with heart failure

If you have severe heart failure (New York Heart Association Class 3 or 4), or if you have symptoms of heart failure (unusually fast weight gain, trouble breathing, or swelling), using this drug may worsen your condition. Don’t take this medication.

urinary system icon
People with kidney damage

If you have severe kidney problems and are on dialysis, don’t use this medication. One of the components of this drug is removed from your body by your kidneys. If your kidneys aren’t working well, more of the drug may stay in your body, putting you at risk for more side effects. Having kidney issues may also increase your risk of heart failure from this drug.

liver icon
People with severe liver damage

If you have severe liver damage, use this medication with caution. There have been cases of liver failure (sometimes fatal) with one of the components of this medication. If you have any symptoms of liver problems such as pain in the upper right part of your abdomen, dark urine, or yellowing of your skin, tell your doctor so they can do blood tests to check your liver function.

warning icon
People with bladder cancer

If you have active bladder cancer or history of bladder cancer, don’t use this drug. Taking this medication could worsen cancer or cause cancer in remission to return.

blood drop icon
People with type 1 diabetes

This medication isn’t appropriate for the treatment of type 1 diabetes.

warning icon
People with diabetic ketoacidosis

This medication isn’t appropriate if you have increased levels of ketones in your blood and urine (diabetic ketoacidosis).

irregular periods
People without regular periods or none at all

Pioglitazone, one of the medicines in this drug, may lead to ovulation in women who are premenopausal. This can increase your risk for pregnancy. Your doctor may recommend you use appropriate birth control.

Pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes through breast milk. There’s a possibility for serious side effects in breastfeeding infants. You and your doctor may need to decide if you’ll take this medication or breastfeed.

Children icon
For children

The effectiveness and safety of this drug haven’t been established in children younger than 18 years old.

Keep this medicine out of the reach of children.

allergy icon
Allergies

This drug may cause a severe allergic reaction. Symptoms may include:

  • trouble breathing or swallowing
  • swelling of your face, lips, throat, and other areas on your skin
  • skin rash, itching, flaking, or peeling
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take alogliptin-pioglitazone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strengths: 12.5 mg alogliptin/15 mg pioglitazone, 12.5 mg alogliptin/30 mg pioglitazone, 12.5 mg alogliptin/45 mg pioglitazone, 25 mg alogliptin/15 mg pioglitazone, 25 mg alogliptin/30 mg pioglitazone, and 25 mg alogliptin/45 mg pioglitazone
Adult Dosage (ages 18 years and older)
  • Dosage usually ranges between 25 mg alogliptin/15 mg pioglitazone and 25 mg alogliptin/45 mg pioglitazone taken once per day.
  • If you’re switching from alogliptin and pioglitazone taken as 2 separate drugs, start the combination drug based on your current total daily dose of the individual drugs.
  • The maximum recommended dose is 25 mg alogliptin/45 mg pioglitazone once per day.
Child Dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Special Considerations

Kidney problems: If you have kidney problems, your body won’t be able to clear this drug as well. This may cause the drug to build up in your body and cause more side effects. Your doctor may start you at a lower dose or prescribe a different medication.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you don't take it at all

If you don’t take it at all, your blood sugar levels could rise. This can possibly damage organs in your body.

If you skip or miss doses

If you miss doses or don’t take it on schedule, this drug won’t be as effective at controlling your blood sugar.

If you take too much

Call your doctor or go to the nearest hospital emergency room right away.

What to do if you miss a dose

If you miss a dose, take it as soon as you remember. If you don’t remember until it’s time for your next dose, skip the missed dose, and take the next dose at your regular time. Don’t take 2 doses of this medication at the same time.

How to tell if the drug is working

Your blood sugar level will go down.

This drug is a long-term drug treatment.

Important considerations for taking this drug
should take with food icon
You can take this medication with or without food
Don’t cut or crush
Don’t split the tablets before swallowing
storage icon
Store this drug from 68–77°F (20–25ºC)
See Details
refillable icon
Prescription is refillable
travel icon
Travel
See Details
Clinical Monitoring icon
Clinical monitoring
See Details
not usually stocked icon
Not every pharmacy stocks this drug, so call ahead
Prior authorization icon
Insurance
See Details

Store this drug from 68–77°F (20–25ºC)

Keep the container tightly closed and protect it from moisture and humidity.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled box with you when traveling.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Your doctor may perform blood tests before and during treatment with this drug to make sure your blood sugar levels are controlled and your kidneys are working well. Your doctor may change your dose, depending on the results of these tests.

When you start taking this drug and any time your doctor increases your dose, you’ll be monitored for side effects related to fluid retention, where your body keeps extra fluid. This could lead to heart problems. Symptoms include weight gain, swelling (in your legs or ankles), or trouble breathing.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 20, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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