Alogliptin benzoate/metformin hydrochloride | Uses etc.
Advertisement

Generic Name:

alogliptin-metformin, Oral tablet

All Brands

  • Kazano
SECTION 1 of 5

Highlights for alogliptin-metformin

Oral tablet
1

This medicine is a combination of two drugs alogliptin and metformin. It’s used along with diet and exercise to lower the blood sugar levels of adults with type 2 diabetes.

2

Don’t use this drug if you have type 1 diabetes or increased ketones in urine or blood. You’ll need insulin to treat these conditions.

3

You take this medicine two times per day with food.

4

Don’t take alogliptin/metformin if your kidneys don’t work well. This could lead to a buildup of metformin in your blood and cause toxic side effects.

5
Drinking excessive amounts of alcohol while taking this drug can lead to a buildup of lactic acid in your blood (lactic acidosis). This is a rare but serious condition. If it isn’t treated, it can cause death.
IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Lactic acidosis. Metformin, one of the medicines in this medication, can cause a buildup of lactic acid in the blood (lactic acidosis). This is a rare but serious condition. If it isn’t treated, it can cause death.

The risk of lactic acidosis increases if you’re dehydrated, have surgery, drink excessive amounts of alcohol, or have liver, kidney or certain types of heart disease. Stop taking this medication and go to the emergency department right away if you feel very weak or tired, have unusual muscle pain, have trouble breathing, have unexplained stomach pains with nausea, vomiting, and diarrhea, feel cold in your arms and legs, and have a slow or irregular heartbeat.

Pancreatitis

One of the drugs in this medication, alogliptin, may cause a sudden inflammation of your pancreas (pancreatitis). Tell your doctor if you have sudden stomach pain that travels to your back, a swollen or tender stomach, or nausea or vomiting.

Liver damage

Alogliptin may cause liver damage. Liver damage can increase your risk of lactic acidosis with metformin. Your doctor will test your liver function before you start taking this medication and during therapy.

Joint pain

This drug may cause severe and disabling joint pain. Tell your doctor right away if you have joint pain. Your doctor may switch you to another medicine to control your diabetes.

Heart failure

This drug may cause heart failure. Your risk may be higher if you have heart or kidney disease. Call your doctor if you have any signs of heart issues. Symptoms of heart failure may include swelling in your ankles and legs and shortness of breath or trouble breathing, especially when you lie down. They can also include fast weight gain and unusual tiredness.

What is alogliptin benzoate and metformin hydrochloride?

This drug is a prescription drug. It’s available as an oral tablet.

This is a combination of two drugs in a single tablet. It’s important to know about all the drugs in the combination because they each may have unique traits.

This combination drug may be used as part of a combination therapy also. That means you may need to take it with other drugs.

Why it's used

This drug is used along with diet and exercise to help lower blood sugar levels in adults with type 2 diabetes.

How it works

This medication contains two drugs: alogliptin and metformin.

More Details

How it works

This medication contains two drugs: alogliptin and metformin.

Alogliptin belongs to a class of drugs called dipeptidyl-peptidase-4 (DPP-4) inhibitors. A class of drugs refers to medications that work similarly. They are often used to treat similar conditions.

Normally after you eat, incretin hormones are released from your small intestine into your blood. They cause insulin to be released by your pancreas into your blood. The insulin helps your body pick up and store the sugar from carbohydrates. The DPP-4 enzyme causes the incretin hormones to become inactive. Alogliptin stops the DPP-4 enzyme from working, so that the hormones can continue to help release insulin and lower your blood sugar levels.

Metformin belongs to a class of drugs called biguanides. It slows down the amount of sugar (glucose) your liver makes, lowers the amount of glucose your body absorbs, and improves your body’s sensitivity to insulin. This helps lower your blood sugar levels.

Advertisement
SECTION 2 of 5

alogliptin-metformin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with this drug include:

  • cold-like symptoms

  • stuffy or runny nose and sore throat

  • diarrhea. This can be decreased if you start with a low metformin dose and increase the dose slowly.

  • increase in blood pressure

  • headache

  • back pain

  • urinary tract infection

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms may include:

    • swelling of your face, lips, or throat
    • difficulty swallowing or breathing
    • skin rash
    • hives
  • liver disease. Symptoms may include:

    • dark urine
    • yellowing of your skin or the whites of your eyes
    • nausea or vomiting
    • tiredness
    • lack of appetite
    • discomfort in the upper right side of your abdomen
  • low blood sugar level. Symptoms may include:

    • shaking or feeling jittery
    • sweating
    • fast heartbeat
    • change in vision
    • dizziness
  • inflammation of your pancreas (pancreatitis). Symptoms may include:

    • sudden pain in stomach that travels to your back
    • swollen and tender stomach
  • low vitamin B12 levels

  • heart failure. Symptoms can include:

    • swelling or fluid retention, especially in your ankles or legs
    • shortness of breath or trouble breathing, especially when you lie down
    • fast weight gain
    • unusual tiredness
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

alogliptin-metformin May Interact with Other Medications

Oral tablet

The combination of alogliptin and metformin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Using excessive amounts of alcohol while taking this drug can increase your risk for a rare but serious condition called lactic acidosis (a buildup of lactic acid in the blood) due to metformin. Alcohol increases how metformin works on lactate. Lactic acidosis, if not treated, can be deadly.

Medications That Might Interact with This Drug

Heart drugs
  • amiloride
  • digoxin
  • triamterene
  • quinidine

These drugs decrease the levels of a chemical called bicarbonate in your blood. Low levels of bicarbonate can increase your risk of lactic acidosis.

  • hydrochlorothiazide
  • calcium channel blockers
    • amlodipine
    • diltiazem
    • nifedipine
    • verapamil

These drugs might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Heartburn drug
  • cimetidine

Taking this drug with alogliptin/metformin can increase the amount of metformin in your body. This could increase your risk of lactic acidosis.

Antiseizure drug
  • topiramate
  • zonisamide
  • acetazolamide

These drugs decrease the levels of a chemical called bicarbonate in your blood. Low levels of bicarbonate can increase your risk of lactic acidosis.

  • phenytoin

This drug might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Corticosteroids
  • prednisone
  • prednisolone
  • methylprednisolone

These drugs might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Thyroid medications
  • levothyroxine
  • Armour thyroid
  • Thyrolar

These drugs might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Oral contraceptives
  • ethinyl estradiol
  • levonorgesterol
  • estrogen
  • estradiol
  • norethindrone

These drugs might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Tuberculosis drug
  • isoniazid

This drug might increase your blood sugar levels. Your dose of alogliptin/metformin might need to be changed when it’s taken with these drugs.

Other diabetes drugs
  • glipizide
  • glyburide
  • glitinides
  • nateglinide
  • repaglinide

These drugs also lower blood sugar levels. Using these drugs with alogliptin/metformin can make your blood sugar level too low and cause a reaction.

Iodine as a contrast agent for X-ray exams

Metformin should be temporarily stopped if you are having an X-ray exam that uses injectable dyes or contrast agents. Iodine in these dyes and agents can increase the risk of lactic acidosis from metformin.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
urinary system icon
People with kidney disease

Metformin can build up in your blood if your kidneys aren’t working well. This causes toxic side effects. Depending on the severity of your kidney disease, your doctor may lower or stop your doses of this drug. Having kidney disease may also raise your risk of heart failure from this drug.

warning icon
People with pernicious anemia

Metformin may lower your vitamin B12 levels. If you have pernicious anemia, taking metformin may make it worse. You doctor will have to monitor your vitamin B12 levels every 2–3 years while you take metformin.

warning icon
People with pancreatitis

One of the drugs in this medication, alogliptin, may cause a sudden inflammation of your pancreas (pancreatitis). If you have pancreatitis and take this drug, your pancreatitis may get worse. Don’t use this product if you currently have an episode of acute pancreatitis.

cardiovascular system icon
People with heart disease

There is a risk of lactic acidosis for people who take this drug. Lactic acidosis is rare but can sometimes cause death. Your risk for lactic acidosis increases if you have heart disease. This drug may cause heart failure. Your risk may be higher if you already have heart problems. Ask your doctor whether this drug is safe for you.

liver icon
People with liver disease

This drug is processed in your liver. If you have liver disease, you may get a buildup of metformin in your body. This can increase your risk of lactic acidosis, a rare but sometimes fatal side effect of metformin.

warning icon
People with conditions that cause reduced oxygen

If you have a condition that lowers oxygen to parts of your body, your risk of lactic acidosis from metformin is increased. This can happen if you have an acute episode of congestive heart failure, a heart attack, or have diseases of the lung such as chronic obstructive pulmonary disease (COPD).

blood drop icon
People with blood infection (septicemia)

The risk of lactic acidosis from the metformin in this drug is increased if you have an infection in your blood.

Pregnant women
Pregnant women

This combination of alogliptin benzoate and metformin hydrochloride is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Speak with your doctor if you’re pregnant or planning to become pregnant. This drug should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if the combination of alogliptin benzoate and metformin hydrochloride passes through breast milk.

You and your doctor should decide if you’ll take this medicine or breastfeed.

senior icon
For seniors

As you get older, your kidney function slows. If you are older than 80 years, your doctor will test your kidney function before and while you take this medication to make sure it doesn’t damage your kidneys.

Children icon
For children

The safety and effectiveness of this drug in people younger than 18 years old haven’t been established.

warning icon
Contact with drug

Don’t share this medicine with others, even if you have the same disease state. It could cause severe side effects. Blood tests are done to make sure this medicine is safe to use.

Allergen icon
Allergies

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take alogliptin-metformin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strength: 12.5 mg alogliptin/500 mg metformin and12.5 mg alogliptin/1000 mg metformin
Adult Dosage (ages 18–79 years)
  • If you are already taking alogliptin or metformin, your doctor will choose your dose based on your current treatment.
  • If you are receiving alogliptin and metformin for the first time, your doctor may start you at 12.5 mg alogliptin/500 mg metformin twice per day.
  • Your dose may be adjusted until your blood sugar improves. Don’t take more than a total of 25 mg of alogliptin per day and 2,000 mg of metformin per day.
  • Take alogliptin/metformin with food, for example, with breakfast and dinner.
Child Dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior Dosage (ages 80 years and older)

As you get older, your kidney function slows. If you are older than 80 years, your doctor will test your kidney function before and while you take this medication to make sure it doesn’t damage your kidneys. If your kidney function is good, you can take the adult dose of the drug.

Special Considerations

Kidney problems: Don’t use this drug if you have poor kidney function.

Liver problems: Don’t use this drug if you have liver disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you don't take it at all

Your diabetes can worsen and lead to other complications, such as nerve damage, eye damage, and kidney damage.

If you don't take it on schedule

If you don’t take this drug on schedule, your blood sugar levels may be too high or too low.

If you take too much

If you take too much of this drug, you may be at a higher risk for lactic acidosis. Lactic acidosis is rare but can sometimes cause death. You may also have low blood sugar, which can be dangerous.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember, unless you remember just a few hours before the time for your next dose. Then only take one dose.

Never try to catch up by taking two tablets at once. This could result in toxic side effects.

How to tell if the drug is working

Your blood sugar levels should be lower.

This drug is a long-term drug treatment.

 

Important considerations for taking this drug
should take with food icon
Take this drug with food to decrease stomach upset
timing icon
Take this drug two times per day as directed by your doctor
not crush or cut icon
Don’t break or cut the tablets
storage icon
Store this drug at 77°F (25°C)
See Details
Prescription refillable icon
Prescription is refillable
travel icon
Travel
See Details
Clinical Monitoring icon
Clinical monitoring
See Details
Not Usually Stocked icon
Not every pharmacy stocks this drug, so call ahead.
Prior authorization icon
Insurance
See Details

Store this drug at 77°F (25°C)

If needed for a short time, you can keep the tablets at 59–86°F (15–30°C).

Keep this product away from high temperature. Don’t store it in your car when it’s hot outside.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription labeled box when traveling with your medication.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Your doctor might have the following tests done:

  • kidney function tests (blood creatinine levels or creatinine clearance or both)
  • liver function tests
  • blood sugar levels

Metformin may decrease vitamin B12 levels. This can cause lower red blood cells or hemoglobin in your blood (pernicious or megaloblastic anemia). To make sure this isn’t happening, your doctor might check:

  • your vitamin B12 levels every 2–3 years
  • your complete blood count every year

Other tests that might be done to check for complications of high blood sugar levels:

  • eye exam at least annually
  • foot exam at least annually
  • dental exam at least annually
  • tests for nerve damage
  • cholesterol levels
  • blood pressure and heart rate

Insurance

Many insurance companies will require prior authorization before they approve the prescription and pay for the combination alogliptin benzoate and metformin hydrochloride tablets.

They may require that you to take each medicine alone before you switch to the combination tablet.

Are there any alternatives?

There are other medicines available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does alogliptin-metformin Cost?

Oral tablet

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

Compare prices and save up to 80% on your next refill!

Lowest price for alogliptin-metformin

Walgreens $94.57
CVS Pharmacy $171.30
Target (CVS) $171.30
These prices represent the lowest priced national pharmacies for alogliptin-metformin on GoodRx. They may be lower than your insurance.

Enter your zip code to find the best deal near you.

These prices represent the lowest priced national pharmacies for alogliptin-metformin on GoodRx. They may be lower than your insurance.

Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 20, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Advertisement
Advertisement
Advertisement