Aliskiren | Side Effects, Dosage, Uses & More
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Generic Name:

aliskiren, Oral tablet

All Brands

  • Tekturna
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Highlights for aliskiren

Oral tablet
1

Aliskiren is an oral drug that’s used to treat high blood pressure (hypertension).

2

Common side effects include diarrhea, cough, dizziness, headache, flu-like symptoms, tiredness, and high levels of potassium in your blood.

3

The standard dose for adults is 150–300 mg of aliskiren taken by mouth one time per day.

4

You shouldn’t take this drug during pregnancy. It can harm a developing baby, and may even be fatal to your baby. If you become pregnant while taking aliskiren, stop taking it and call your doctor right away.

5

Your doctor will monitor your blood pressure at your checkups. You also may need to check your blood pressure at home. It’s helpful to keep a diary of the date, time of day, and your blood pressure readings.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. You shouldn’t take this drug during pregnancy. It can harm a developing baby. It may even be fatal. If you become pregnant while taking aliskiren, stop taking it and call your doctor right away.

Low blood pressure

When you first start taking aliskiren, you may have low blood pressure. Tell your doctor if you feel lightheaded or like you’re going to faint. Don’t take aliskiren again until you talk to your doctor. You may have an increased risk of low blood pressure if you:

  • don’t drink enough fluids
  • sweat a lot
  • have diarrhea, or vomiting

Diabetes

If you have diabetes and are taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) drug, you shouldn’t take aliskiren. Taking this drug may increase your risk of kidney problems, low blood pressure, and high levels of potassium in your blood.

What is aliskiren?

Aliskiren is a prescription drug. It’s available as an oral tablet.

Aliskiren isn’t available as a generic drug.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Aliskiren is used to treat high blood pressure.

How it works

Aliskiren belongs to a class of drugs called direct renin inhibitor.

More Details

How it works

Aliskiren belongs to a class of drugs called direct renin inhibitor. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Aliskiren reduces the amount of the enzyme renin in your body. This can help your blood vessels relax and widen, which makes your blood pressure lower.

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aliskiren Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with aliskiren include:

  • diarrhea

  • cough

  • dizziness

  • headache

  • flu-like symptoms, such as fever and chills

  • tiredness

  • high levels of potassium in your blood (hyperkalemia)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe allergic reaction. Symptoms include:

    • trouble breathing or swallowing
    • tightness in your chest
    • hives
    • skin rash
    • itching
    • dizziness
    • vomiting
    • stomach pain
    • swelling of your face, lips, tongue, throat, arms, legs, or whole body
  • low blood pressure (hypotension). Symptoms include:

    • feeling faint or dizzy
    • lightheadedness
    • tiredness
  • kidney damage. Symptoms include:

    • not urinating as much as normal
    • tiredness
    • shortness of breath
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Aliskiren may cause drowsiness.

When you first start taking aliskiren, you may have low blood pressure. Tell your doctor if you feel lightheaded or like you’re going to faint. Don’t take aliskiren again until you talk to your doctor. You may have an increased risk of low blood pressure if you:

  • don’t drink enough fluids
  • sweat a lot
  • have diarrhea, or vomiting
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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aliskiren May Interact with Other Medications

Oral tablet

Aliskiren can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Food interactions

Don’t take aliskiren with a high fat meal because it can decrease the amount of drug in your body. This means that the drug may not work as well to treat your high blood pressure.

Medications that might interact with this drug

Blood pressure medications

When taken with aliskiren, these drugs may harm your kidneys.

These drugs include:

  • angiotensin receptor blockers (ARB), such as:
    • candesartan
    • eprosartan
    • irbesartan
    • losartan
    • olmesartan
    • telmisartan
    • valsartan
    • azilsartan
  • angiotensin-converting enzyme (ACE) inhibitors, such as:
    • benazepril
    • captopril 
    • enalapril
    • fosinopril
    • lisinopril
    • moexipril
    • perindopril
    • quinapril
    • ramipril
    • trandolapril

Fungal infections drugs

These medicines may increase the amount of aliskiren in your body. This means that you may have more side effects.

These drugs include:

  • itraconazole

Kidney transplant drugs

These drugs may increase the amount of aliskiren in your body. This means that you may have more side effects.

These drugs include:

  • cyclosporine

Pain medications

When taken with aliskiren, these drugs may harm your kidneys.

These drugs include:

  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • ibuprofen
    • naproxen
  • COX-2 inhibitors, such as:
    • celecoxib
    • meloxicam

Water pills (diuretics)

Aliskiren may decrease the amount of this medication in your body. That means that it won’t work as well.

These drugs include:

  • furosemide

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Aliskiren warnings
kidney disease
People with kidney disease

This drug can cause changes in your kidney function, including acute kidney failure. Your doctor will check your kidney function while you’re taking aliskiren.

diabetes
People with diabetes

If you have diabetes and are taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) drug, you shouldn’t take aliskiren. Taking this drug may increase your risk of kidney problems, low blood pressure, and high levels of potassium in your blood.

pregnant women
Pregnant women

Aliskiren is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

You shouldn’t take this drug during pregnancy. It can harm a developing baby, and may even be fatal to your baby.

Tell your doctor right away if you’re pregnant or plan to become pregnant. Aliskiren should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

Aliskiren may pass into breast milk and may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

As you age, your organs (such as your liver, heart, or kidneys) may not work as well as they did compared to when you were younger. More of this drug may stay in your body longer. This puts you at a greater risk for side effects.

for children
For children

The safety and effectiveness of aliskiren haven’t been established in children under the age of 18 years.

call doctor
When to call the doctor

Tell your doctor right away if you get pregnant while taking aliskiren. This drug can harm your developing baby.

allergies
Allergies

Aliskiren can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take aliskiren (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure

Brand: Tekturna

Form: Oral tablet
Strengths: 150 mg and 300 mg
Adult dosage (ages 18 years and older)
  • starting dose: 150 mg taken by mouth once per day
  • dose increases: If this isn’t enough to control your blood pressure, your doctor may increase your dose to 300 mg taken once per day.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Aliskiren/hydrochlorothiazide comes with serious risks if you don't take it as prescribed.

If you don't take it at all

Aliskiren lowers high blood pressure. If high blood pressure isn’t treated, it can lead to stroke, heart attack, heart failure, kidney failure, and vision problems.

f you take too much

If you take too much aliskiren, your blood pressure might become too low. Symptoms include:

  • feeling faint or dizzy
  • lightheadedness
  • tiredness

If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

How to tell if the drug is working

You may be able to tell that this drug is working if your blood pressure is lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

Aliskiren is a long-term drug treatment.

Don’t take aliskiren with a high fat meal

Taking aliskiren with a high fat meal can decrease the amount of drug in your body. This means that the drug may not work to lower your blood pressure.

Store aliskiren at room temperature

Keep it from 59–86°F (15–30°C).

Don’t freeze aliskiren.

Keep this drug away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Keep aliskiren in its original prescription bottle in a dry place. Don’t remove the little packet that comes in the pill container (desiccant) from the bottle.

Keep this drug and all medicines out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

You may need to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

Clinical monitoring

Before starting and while taking aliskiren, your doctor may check your:

  • blood pressure
  • heart rate
  • kidney function. Aliskiren can cause changes in kidney function, including acute kidney failure.
  • potassium level. This drug can increase the level of potassium in your blood (hyperkalemia).

Your diet

Don’t take aliskiren with a high fat meal because it can increase the amount of the drug in your body. This can cause more side effects.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for aliskiren.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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How Much Does aliskiren Cost?

Oral tablet

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Lowest price for aliskiren

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These prices represent the lowest priced national pharmacies for aliskiren on GoodRx. They may be lower than your insurance.

Show Sources

  • Tekturna –aliskiren hemifumarate [package insert]. East Hanover, NJ: Novartis Pharmaceutical Corporation; Revised March 2015.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 2, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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