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Generic Name:

aliskiren-hydrochlorothiazide, Oral tablet

All Brands

  • Tekturna HCT
SECTION 1 of 4

Highlights for aliskiren-hydrochlorothiazide

Oral tablet
1

Aliskiren/hydrochlorothiazide is a combination of two drugs in a single form that’s used to treat high blood pressure.

2

Common side effects include dizziness, flu-like symptoms, diarrhea, cough, and tiredness.

3

Your doctor will decide a dose that’s right for you. It will be based on your blood pressure levels and how you respond to this drug. You’ll take your aliskiren/hydrochlorothiazide oral tablet one time per day. It comes in these strengths: 150 mg aliskiren/12.5 mg hydrochlorothiazide, 150 mg aliskiren/25 mg hydrochlorothiazide, 300 mg aliskiren/12.5 mg hydrochlorothiazide, and 300 mg aliskiren/25 mg hydrochlorothiazide.

4

Your doctor will monitor your blood pressure at your checkups. You may also need to test your blood pressure at home. For your home checks, you should keep a diary of the date, time of day, and your blood pressure readings. Bring this log with you to your doctor appointments.

5

You shouldn’t take this drug during pregnancy. It can harm your developing baby. It may even be fatal. If you become pregnant while taking aliskiren/hydrochlorothiazide, stop taking it right away and call your doctor.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning: You shouldn’t take this drug during pregnancy. It can harm your developing baby. It may even be fatal. If you become pregnant while taking this drug, stop taking it right away and call your doctor.

High blood potassium

This drug can increase the level of potassium in your blood (hyperkalemia). Your risk may be higher if you also have kidney disease or are taking other medications that increase your potassium level. Your doctor should monitor your potassium levels during treatment with this drug.

Low blood pressure

This drug may cause low blood pressure, especially during the first few days of treatment with it. Tell your doctor if you feel lightheaded or like you’re going to faint. Your risk of low blood pressure may be higher if you:

  • don’t drink enough fluids
  • sweat heavily
  • have diarrhea or vomiting

Diabetes

If you have diabetes and are taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) drug, you shouldn’t take this drug. Taking this drug may increase your risk of kidney problems, low blood pressure, and high levels of potassium in your blood.

What is aliskiren/hydrochlorothiazide?

This drug is a prescription drug. It’s available as an oral tablet. 

This drug is a brand-name drug. It’s not available as a generic drug. 

This drug is a combination of two medicines in a single form.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

This drug is used to treat high blood pressure in adults.

How it works

This drug is a combination of two medicines in a single form: aliskiren and hydrochlorothiazide.

More Details

How it works

This drug is a combination of two medicines in a single form: aliskiren and hydrochlorothiazide. Aliskiren belongs to a class of drugs called direct renin inhibitors. Hydrochlorothiazide belongs to a class of drugs called thiazide diuretics. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions. 

Aliskiren can help your blood vessels relax and widen so blood pressure is lower. This drug is a direct renin inhibitor. By reducing renin, it helps to lower blood pressure. Hydrochlorothiazide reduces the amount of salt and water in your body. This makes your blood pressure lower. 

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SECTION 2 of 4

aliskiren-hydrochlorothiazide Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with aliskiren/hydrochlorothiazide include:

  • dizziness

  • flu-like symptoms, such as fever and chills

  • diarrhea

  • cough

  • tiredness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe allergic reactions. Symptoms include:

    • trouble breathing or swallowing
    • tightness in your chest
    • hives
    • skin rash
    • itching
    • dizziness
    • vomiting
    • stomach pain
    • swelling of your face, lips, tongue, throat, arms, legs, or your whole body
  • low blood pressure. Symptoms include:

    • feeling faint or dizzy
    • lightheadedness
    • tiredness
  • lupus. Symptoms include:

    • joint pain and stiffness
    • weight loss
    • fatigue
    • skin rash
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug may cause drowsiness.

When you first start taking this drug, you may have low blood pressure. Tell your doctor if you feel lightheaded or like you’re going to faint. Don’t take this medicine again until you talk to your doctor. Your risk of low blood pressure may be higher if you:

  • don’t drink enough fluids
  • sweat heavily
  • have diarrhea or vomiting
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

aliskiren-hydrochlorothiazide May Interact with Other Medications

Oral tablet

Aliskiren/hydrochlorothiazide can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Food interactions

You shouldn’t take aliskiren/hydrochlorothiazide with a high fat meal because it can decrease the amount of drug in your body. This means that it may not work as well to lower your blood pressure. If you eat a high fat meal, wait 2–3 hours before taking this drug.

Alcohol interaction

Drinking alcohol while taking this drug might increase your risk for low blood pressure upon standing (orthostatic hypotension). Limit your alcohol intake while taking aliskiren/hydrochlorothiazide and stand up slowly after lying or sitting down.

Medications that might interact with this drug

Cholesterol-lowering drugs

These drugs may increase the effects of aliskiren/hydrochlorothiazide. This means that you may have more side effects.

These drugs include:

  • atorvastatin

Drugs that suppress your immune system

These medications may increase the effects of aliskiren/hydrochlorothiazide. This means that you may have more side effects.

These drugs include:

  • cyclosporine

Antifungal drugs

These medications may increase the effects of aliskiren/hydrochlorothiazide. This means that you may have more side effects.

These drugs include:

  • ketoconazole

Heart failure and cholesterol-lowering drugs

These drugs may decrease the effects of aliskiren/hydrochlorothiazide. This means that it may not work as well to lower your blood pressure.

These drugs include:

  • cholestyramine
  • colestipol

Pain drugs

These drugs may decrease the effects of aliskiren/hydrochlorothiazide. This means that it may not work as well to lower your blood pressure.

These drugs include:

  • non-steroidal anti-inflammatory drugs (NSAIDs), such as:
    • ibuprofen
    • naproxen

Mood stabilizers

Aliskiren/hydrochlorothiazide may increase the effects of these medications. That means that you may have more side effects.

These drugs include:

  • lithium

Diabetes drugs

Aliskiren/hydrochlorothiazide may increase your blood sugar. Your doctor may need to give you a higher dose of your diabetes medication.

These drugs include:

  • insulin
  • exenatide
  • metformin
  • glimepiride
  • pioglitazone
  • sitagliptin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
lupus
People with lupus

This drug can cause new or worse lupus symptoms. Call your doctor right way if this happens.

diabetes
People with diabetes

If you have diabetes and are taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) drug, you shouldn’t take this drug. Taking this drug may increase your risk of kidney problems, low blood pressure, and high levels of potassium in your blood.

kidney disease
People with kidney disease

You shouldn’t take this drug if you have severe kidney disease.

pregnant women
Pregnant women

Ths drug is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

Tell your doctor if you’re pregnant or plan to become pregnant. Taking this drug during pregnancy can harm your developing baby. It may even be fatal. If you become pregnant while taking this drug, stop taking it right away and call your doctor.

This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

This drug may pass into breast milk and cause serious effects in a child who is breastfed.

You and your doctor may need to decide if you’ll take this drug or breastfeed.

for seniors
For seniors

Older adults may process this drug more slowly. A normal adult dose may cause levels of the drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

The safety and effectiveness of this drug haven’t been established in children younger than 18 years.

call doctor
When to call the doctor

Tell your doctor if you’re pregnant or plan to become pregnant while taking this drug.

allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

SECTION 4 of 4

How to Take aliskiren-hydrochlorothiazide (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure (hypertension)

Brand: Tekturna HCT

Form: Oral tablet
Strengths:
  • 150 mg aliskiren/12.5 mg hydrochlorothiazide
  • 150 mg aliskiren/25 mg hydrochlorothiazide
  • 300 mg aliskiren/12.5 mg hydrochlorothiazide
  • 300 mg aliskiren/25 mg hydrochlorothiazide
Adult dosage (ages 18–64 years)

The recommended starting dose is 150 mg aliskiren/12.5 mg hydrochlorothiazide taken by mouth once daily. Your doctor may increase your dose if needed.

Child dosage (ages 0–17 years)

The safety and effectiveness of aliskiren/hydrochlorothiazide in people younger than 18 years haven’t been established.

Senior dosage (ages 65 years and older)

Older adults may process this drug more slowly. A normal adult dose may cause levels of the drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Special considerations

Kidney disease: You shouldn’t take aliskiren/hydrochlorothiazide if you have severe kidney disease. Your dose doesn’t need to be adjusted if you have mild or moderate kidney disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time of your next dose, then wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you don't take it at all

This drug reduces high blood pressure. High blood pressure makes the heart work harder to pump blood throughout the body. If high blood pressure isn’t treated, it can lead to stroke, heart attack, heart failure, kidney failure, and vision problems. Taking your medicine reduces these risks.

If you take too much

If you take too much of this drug, your blood pressure might become too low. Symptoms of low blood pressure include:

  • feeling faint or dizzy
  • lightheadedness
  • tiredness

If you think that you’ve taken too much of this drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room.

How to tell this drug is working

You may be able to tell that this drug is working if your blood pressure is lower. Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

This drug is used for long-term treatment.

This drug must be stored at the right temperature

  • Store this drug at room temperature between 59°F (15°C) and 86°F (30°C).
  • Don’t freeze this drug.
  • Keep this drug away from light.
  • Keep it away from high temperature.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.
  • Keep this drug in its original prescription bottle in a dry place. Don’t remove the little packet that comes in the pill container (desiccant) from the bottle.
  • Keep this drug and all medicines out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s preprinted label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Self-management

You may need to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your checkups.

Clinical monitoring

During treatment with this drug, your doctor may check your:

  • blood pressure. This will help your doctor tell if the drug is working.
  • potassium level. This drug can increase the level of potassium in your blood (hyperkalemia). Your risk may be at higher if you also have kidney disease or are taking other medications that increase your potassium level. Your doctor should monitor your potassium levels during treatment with this drug.

Your diet

Don’t take this drug with a high fat meal because it can increase the amount of drug in your body. This means that it may not work as well to lower your blood pressure. If you eat a high fat meal, wait 2–3 hours before taking this drug.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

  • Novartis Pharmaceutical Corporation. (2010, February). Tekturna HCT – aliskiren hemifumarate and hydrochlorothiazide. East Hanover, NJ.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 7, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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