Generic Name: alfuzosin, Oral tablet

Uroxatral

All Brands

  • Uroxatral
SECTION 1 of 4

Highlights for alfuzosin

Oral tablet
1

Alfuzosin is used to treat benign prostatic hyperplasia (BPH) in adult men. It helps relax the muscles in your prostate and bladder, which can reduce BPH symptoms and improve your ability to urinate.

2 3

Common side effects include dizziness, headache, and tiredness.

4

Alfuzosin belongs to a class of drugs that sometimes treats high blood pressure. Alfuzosin should not be used to treat high blood pressure. It also shouldn’t be used by women or children.

5

Don’t take alfuzosin if you have liver problems. If your liver isn’t working well, more of the drug may stay in your body. This puts you at risk for more side effects.

IMPORTANT INFORMATION

Blood pressure warning

Alfuzosin may cause a sudden drop in your blood pressure when you change positions (such as standing up from sitting or lying down). It may also cause fainting. Avoid driving, operating heavy machinery, or performing hazardous tasks until you know how it affects you. If you start feeling dizzy or lightheaded, lie down with your legs and feet up. Get medical attention if these effects don’t improve.

Chest pain warning

Alfuzosin can cause serious side effects to your heart. If you experience new or worsening symptoms of sharp or squeezing chest pain (angina), stop taking alfuzosin and talk to your doctor or get immediate medical attention. Get medical attention if you have pain that moves to your arms, neck, or back; or other symptoms, such as trouble breathing, sweating, dizziness, or nausea.

Drug Features

Alfuzosin is a prescription medication. It’s available as an oral extended-release tablet.

It’s also available in a generic version. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Alfuzosin is used to treat benign prostatic hyperplasia (BPH) in adult men.

How It Works

Alfuzosin belongs to a class of drugs called alpha blockers.

More Details

How It Works

Alfuzosin belongs to a class of drugs called alpha blockers. It works by helping to relax muscles in your prostate and bladder. This can reduce your BPH symptoms and improve your ability to urinate.

Alpha blockers work on alpha receptors in your body. There are alpha receptors in many parts of your body, but this specific medication only acts on the receptors in your prostate and bladder.

SECTION 2 of 4

alfuzosin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with alfuzosin include:

  • dizziness

  • headache

  • tiredness

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • sudden drop in blood pressure. Symptoms may include:

    • dizziness or lightheadedness when changing position and standing
    • an episode of passing out or unconsciousness
  • prolonged erection (priapism). This is an erection that can’t be relieved by having sex. Get medical help right away if this happens. If it isn’t treated, you may have permanent erection problems

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Alfuzosin does not cause drowsiness.

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

alfuzosin May Interact with Other Medications

Oral tablet

Alfuzosin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

BPH and blood pressure drugs

Avoid using alfuzosin with other alpha blockers. Combining the drugs may increase your risk of side effects since the medications work similarly.

Examples are:

  • doxazosin (Cardura, Cardura XL)
  • prazosin (Minipress)
  • silodosin (Rapaflo)
  • tamsulosin (Flomax)
  • terazosin (Hytrin)

Blood pressure drugs

Using blood pressure medications and alfuzosin together may increase your risk of low blood pressure, a sudden drop in your blood pressure when standing, or fainting.

Examples are:

  • aldosterone antagonists, such as:
    • spironolactone
    • eplerenone
  • angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
    • benazepril
    • lisinopril
    • enalapril
    • fosinopril
  • angiotensin receptor blockers (ARBs), such as:
    • losartan
    • candesartan
    • olmesartan
    • telmisartan
    • valsartan
  • beta blockers, such as:
    • atenolol
    • bisoprolol
    • metoprolol
    • propranolol
  • calcium channel blockers, such as:
    • amlodipine
    • nifedipine
    • nicardipine
    • diltiazem
    • verapamil
  • centrally-acting adrenergic agent, such as:
    • clonidine
    • guanfacine
    • methyldopa
  • direct renin inhibitors, such as aliskiren
  • diuretics, such as:
    • amiloride
    • chlorthalidone
    • furosemide
    • metolazone
  • vasodilators, such as:
    • hydralazine
    • minoxidil
  • nitrates, such as:
    • isosorbide mononitrate
    • isosorbide dinitrate
    • nitroglycerin transdermal patch

Erectile dysfunction and pulmonary hypertension drugs

These include phosphodiesterase-5 (PDE-5) inhibitors. These drugs are used to treat erectile dysfunction and sometimes high blood pressure. Using them with alfuzosin may lead to very low blood pressure.

Examples are:

  • avanafil (Stendra)
  • sildenafil (Viagra, Revatio)
  • tadalafil (Adcirca, Cialis)
  • vardenafil (Levitra, Staxyn)

Drugs that inhibit CYP3A4 enzyme

The CYP3A4 enzyme processes alfuzosin in your liver. Medications that block this liver enzyme may cause the levels of alfuzosin to increase in your body. This may put you at risk for more side effects. Alfuzosin shouldn’t be used with strong inhibitors of this enzyme.

A few examples are:

  • ketoconazole
  • itraconazole
  • ritonavir

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver problems

Don’t take alfuzosin if you have severe liver problems. If your liver isn’t working well, more of the drug may stay in your body. This increases your risk of side effects.

People with kidney problems

Use this medication with caution if you have severe kidney problems. If your kidneys aren’t working well, more of the drug may stay in your body. This increases your risk of side effects.

People with rhythm heart problems

Use this drug with caution if you have a heart condition known as QT prolongation or if you’re taking medications that lengthen QT interval. It isn’t known how alfuzosin will affect your QT interval.

People with prostate cancer

Benign prostatic hyperplasia and prostate cancer cause similar symptoms, but prostate cancer is treated with different medications. Your doctor will examine your prostate gland and do a blood test called a prostate specific antigen (PSA) test to check for prostate cancer before starting you on alfuzosin.

People having cataract surgery

If you’re having cataract surgery and are taking alfuzosin (or have a history of taking it), you may be at increased risk for having a complication during the surgery known as intraoperative floppy iris syndrome (IFIS). Let your eye doctor know if you’re taking this medication. Your eye doctor may need to change the technique for your eye surgery to decrease your risk for IFIS. There doesn’t appear to be any benefit of stopping alfuzosin before your eye surgery.

Pregnant women

Alfuzosin is used to treat benign prostatic hyperplasia in men only. Women shouldn’t use this drug, and there are no studies of alfuzosin in pregnant women.

Women who are nursing

Alfuzosin is used to treat benign prostatic hyperplasia in men only. Women shouldn’t use this drug.

For Seniors

Alfuzosin is safe and effective for adults aged 65 years or older. However, seniors may not be able to clear this drug well. This can lead to more of the drug staying in your body, putting you at greater risk of side effects.

For Children

Alfuzosin should not be used in children.

Allergies

Alfuzosin can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat, tongue, face, or lips
  • hives
  • itching skin or rash
  • peeling or blistering skin
  • fever
  • chest tightness

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

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How to Take alfuzosin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Benign prostatic hyperplasia (BPH)
Form: Oral extended-release tablet
Strength: 10 mg
Adult Dosage (ages 18 years and older)

The recommended dose is 10 mg taken once per day.

Child Dosage (ages 0–17 years)

This drug should not be used in children.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Alfuzosin comes with risks if you don’t take it as prescribed

If You Don’t Take It at All or Stop Taking It

If don’t take or stop taking alfuzosin, you may have increased symptoms of BPH, such as difficulty starting to urinate, straining while trying to urinate, frequent urges to urinate, pain during urination, and dribbling after urination. It’s important to continue taking your medication as directed by your doctor, even if you feel better. Doing so will provide the best chance of managing BPH and improving your quality of life.

If You Take Too Much

Taking too much alfuzosin may lead to:

  • low blood pressure. Symptoms include dizziness, lightheadedness, and fainting.
  • other problems with your heart
  • shock

If you think you’ve taken too much, call your doctor or get emergency medical help right away.

What to Do If You Miss a Dose

You should take this medication once a day. If you miss a dose, take it as soon as you can. If it’s close to time for your next dose, skip the missed dose.

Don’t make up the missed dose by taking 2 doses the next day. This could be toxic.

How to Tell If the Drug Is Working

You may be able to tell this drug is working if your symptoms improve.

Alfuzosin is a long-term treatment.

Important Considerations for Taking Alfuzosin
should take with food icon Take with food at the same time each day See Details
timing icon Take alfuzosin with the same meal each day
don not crush icon Don’t crush or chew these tablets
storage icon Store in temperatures from 59–86°F (15– 30°C) See Details
Prescription  refillable icon Prescription is refillable
travel icon Travel See Details
not usually stocked icon Not every pharmacy stocks this drug, so call ahead
prior authorization icon Insurance See Details

Take with food at the same time each day

If you don’t take this medication with food, it won’t be fully absorbed by your body and it may not work as well.

Store in temperatures from 59–86°F (15– 30°C)

Protect this medication from light and moisture.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for alfuzosin.

What does the pill look like?

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Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 18, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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