Generic Name: afatinib, Oral tablet

GILOTRIF

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  • GILOTRIF
SECTION 1 of 4

Highlights for afatinib

Oral tablet
1
AFATINIB (a FA ti nib) is a chemotherapy drug. It targets a specific protein within cancer cells and stops the cancer cells from growing. This medicine is used to treat non-small cell lung cancer.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

afatinib Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bloody or black tarry stools
  • eye irritation
  • eye pain
  • fever
  • mouth sores
  • problems related to breathing including shortness of breath or cough
  • severe or persistent diarrhea, nausea, vomiting, or loss of appetite
  • spitting up blood or brown material that looks like coffee grounds
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • acne
  • diarrhea
  • dry skin
  • itching
  • loss of appetite
  • nausea
  • weak or tired
  • weight loss
SECTION 3 of 4

afatinib May Interact with Other Medications

Oral tablet
  • amiodarone
  • carbamazepine
  • certain medicines for fungal infections like ketoconazole and itraconazole
  • cyclosporine A
  • erythromycin
  • grapefruit juice
  • nelfinavir
  • phenobarbital
  • phenytoin
  • quinidine
  • rifampicin
  • ritonavir
  • saquinavir
  • St. John's wort
  • tacrolimus
  • verapamil
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 4

How to Use afatinib

Oral tablet

Take by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • eye disease, vision problems, or if you wear contact lenses
  • heart disease
  • kidney disease
  • liver disease
  • lung or breathing disease
  • an unusual or allergic reaction to afatinib, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

Take your missed dose as soon as you remember. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Report any side effects. Continue your course of treatment unless your doctor tells you to stop. You will need blood work done while you are taking this medicine.

If you experience any of the following, contact your health care provider: eye irritation; rash; severe or continuing diarrhea, nausea, decreased appetite, or vomiting; or if your breathing gets worse or you develop shortness of breath or cough.

Do not become pregnant while taking this medicine or for 2 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

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Last Updated: August 8, 2013

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