Highlights for acetaminophen
Acetaminophen injection is used to reduce pain and fever.
A healthcare provider in a hospital or doctor’s office will give you this injection. You won’t take it yourself at home.
Common side effects include nausea, headache, and trouble sleeping.
This drug may cause serious damage to your liver and lead to liver failure or death. Your risk increases if you take more than 4,000 mg of acetaminophen per day.
This drug may cause serious, potentially fatal skin reactions like Steven-Johnson syndrome and toxic epidermal necrolysis. Symptoms may include rash, blistering, or peeling skin.
What is acetaminophen injection?
This drug is given by a healthcare provider only. You won’t take it on your own.
Why it's used
This drug is used to reduce pain and fever.
How it works
It isn’t fully known how this drug works.
acetaminophen Side Effects
Most Common Side Effects
The most common side effects that occur with acetaminophen injection include:
feeling restless or agitated
Serious Side Effects
If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.
potentially severe or life-threatening allergic reaction. Symptoms may include:
- trouble breathing
- swelling of your face, throat, and mouth
liver damage. Symptoms may include:
- yellowing of your skin or whites of your eyes
- dark colored urine
- pain in your stomach
- lack of appetite
- feeling tired
serious skin reactions, such as Steven-Johnson syndrome and toxic epidermal necrolysis. Symptoms may include:
- peeling skin
This drug doesn’t cause drowsiness.
Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.
acetaminophen May Interact with Other Medications
Acetaminophen injection can interact with other medications, herbs, or vitamins you might be taking. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs or vitamins you’re taking.
Drinking alcohol while you’re on this medication can affect how acetaminophen is processed in your body. This makes it more likely for acetaminophen to cause damage to your liver. Your doctor will decide if this drug is safe for you based on your alcohol use.
How to Take acetaminophen (Dosage)
Your doctor will determine a dose that is right for you based on your individual needs. Your general health may affect your dose. Tell your doctor about all health conditions you have before your doctor or nurse administers the drug to you.
Acetaminophen injection maybe given as a one-time dose or a repeated dose to treat short-term (acute) pain or fever.
This is a short-term medication.
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- Ofirmev – acetaminophen injection. (2014). Retrieved from http://www.ofirmev.com/downloads/pdf/OFIRMEVPrescribingInformation.pdf
- Ofirmev (acetaminophen) injection. (2013, October). Retrieved from http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022450s005s006lbl.pdf
Content developed in collaboration with University of Illinois-Chicago, Drug Information Group
Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 19, 2015