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Generic Name:

acetaminophen-oxycodone, Oral tablet

Generic Name:
Magnacet,Narvox,Percocet,Perloxx,Primalev,Primlev,Xolox

acetaminophen-oxycodone, Oral tablet

All Brands

  • Magnacet (Discontinued)
  • Narvox (Discontinued)
  • Percocet
  • Perloxx (Discontinued)
  • Primalev (Discontinued)
  • Primlev
  • Xolox (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 4

Highlights for acetaminophen-oxycodone

Oral tablet
1

Oxycodone hydrochloride/acetaminophen is an oral medication used to treat moderate to severe pain.

2

This medication may cause severe or life threatening reactions in people with asthma or other lung problems, an allergy to the drug, or a bowel blockage.

3

Don’t take more medication than prescribed. In general, the maximum safe dosage of acetaminophen, including acetaminophen in all medications you take, is 4,000 mg per day.

4

This medication may be addicting or habit forming, even at regular doses. Never share it, especially with someone with a history of drug misuse.

5

This medication can have negative effects in people with certain health conditions. Tell your doctor if you have seizures, head injuries, and problems urinating.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Addiction, abuse, and misuse: This medication has a risk of addiction, abuse, and misuse, which can lead to overdose and death.

Life-threatening breathing problems: Serious, life-threatening, or fatal inability to breathe may occur when you use this drug, especially in older adults. Swallow extended-release tablets whole to avoid a potentially fatal overdose.

Accidental use: Accidentally taking this medication can cause a fatal overdose of oxycodone. This is especially true for children.

Neonatal opioid withdrawal syndrome: If you use this medication for a long time while you’re pregnant, it can cause withdrawal in your baby. Withdrawal in your baby can lead to death. Symptoms of withdrawal may include:

  • irritability
  • hyperactivity and unusual sleep pattern
  • high-pitched cry
  • tremor
  • vomiting
  • diarrhea
  • failure to gain weight

Liver problems: Acetaminophen has been associated with cases of acute liver failure. This can result in the need for a liver transplant or death. Don’t take more than the maximum daily limit of acetaminophen (4,000 mg per day).

Extended-release warning

Don’t use the extended-release form if you’ve been prescribed a different form. The extended-release form contains more of the drug. Using it at the same dose as the other forms can lead to increased side effects and even death.

Blood pressure warning

Contact your doctor if you experience dizziness, feeling faint, or trouble breathing. 

What is acetaminophen-oxycodone?

This is a prescription medication and a controlled substance. It’s available in these forms: oral tablet, oral extended-release tablet, and oral solution.

It’s available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you may need to take it with other drugs.

Why it's used

This drug is used to treat moderate to severe pain.

How it works

This medication is a combination of oxycodone hydrochloride and acetaminophen.

More Details

How it works

This drug is a combination of oxycodone hydrochloride and acetaminophen. Oxycodone is an opiate analgesic (narcotic) and acetaminophen is an analgesic (pain reliever). Both drugs are used to reduce pain.

These drugs work in your brain to block pain signals. They cause a decrease in your ability to feel pain.

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SECTION 2 of 4

acetaminophen-oxycodone Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with oxycodone hydrochloride/acetaminophen include:

  • nausea

  • dizziness

  • headache

  • vomiting

  • constipation

  • sleepiness or drowsiness

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • liver problems. Symptoms may include:

    • dark urine, light colored stool
    • feeling full, not being hungry, and vomiting
    • yellowing of your skin or whites of your eyes
  • skin problems. Symptoms may include:

    • skin rash
    • peeling, blistering skin
  • increased pressure in your skull

  • very low blood pressure, which can cause dizziness and falling

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This medication may make you feel sleepy, dizzy, or lightheaded. Avoid driving a car or operating machinery until you know how your body reacts to it.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

acetaminophen-oxycodone May Interact with Other Medications

Oral tablet

Oxycodone hydrochloride/acetaminophen can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Drinking alcohol while taking this medication increases your risks of negative side effects. These include slowed breathing and increased drowsiness. It also increases your risk of liver damage.

Medications That Might Interact with This Drug

Drugs that cause drowsiness

Taking these drugs with oxycodone hydrochloride/acetaminophen increases your risk of drowsiness, physical and mental slowing, and trouble breathing. If you need to use both drugs together, the dose of one or both should be reduced.

These drugs include:

  • sedatives
  • hypnotics
  • tranquilizers
  • general anesthetics
  • skeletal muscles relaxants
  • other opioids

Anticoagulant, blood thinner
  • warfarin

Antidepressants

Avoid taking oxycodone hydrochloride/acetaminophen with monoamine oxidase inhibitors. Monoamine oxidase inhibitors can increase your risk for anxiety, confusion, breathing problems, and coma.

Pain and opiate addiction/withdrawal drugs

Avoid taking oxycodone hydrochloride/acetaminophen with agonist/antagonist analgesics. They can decrease how well your pain medication works, which will cause you to feel more pain.

These drugs include:

  • pentazocine
  • nalbuphine
  • butorphanol
  • buprenorphine

Anticholinergics

Avoid taking oxycodone hydrochloride/acetaminophen with anticholinergics. They may make it hard for you to go to have a bowel movement, which can lead to severe problems in your stomach and intestines.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
lung problems
People with lung problems

If you have severe asthma, trouble breathing, or other lung problems, this medication can increase your risk of breathing problems. This is because it slows your breathing even more.

stomach problems
People with stomach problems

If you have a bowel blockage or narrowing of your stomach or intestines, taking this medication can make it even harder for you to have a bowel movement. This is because it tends to cause constipation.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. This drug should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.

If you use this medication for a long time while you’re pregnant, it can cause withdrawal in your baby (neonatal opioid withdrawal syndrome). Withdrawal in your baby can lead to death. Symptoms of withdrawal may include:

  • irritability
  • hyperactivity and unusual sleep pattern
  • high-pitched cry
  • tremor
  • vomiting
  • diarrhea
  • failure to gain weight
breastfeeding
Women who are breast-feeding

You shouldn’t breastfeed your baby while taking this medication. If you do, your baby may become too sleepy and may have problems breathing.

You and your doctor should decide whether you take this medication or breastfeed.

children
For children

The effectiveness and safety of this medication hasn’t been established in children under the age of 18 years.

allergies
Allergies

This medication can cause serious skin problems. Symptoms may include skin rash and peeling, blistered skin.

Get emergency medical help if you experience:

  • trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue or throat, extreme drowsiness, or feeling faint
  • rash with hives, sores in your mouth or eyes, or blistering and peeling skin

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take acetaminophen-oxycodone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Mild to moderate pain
Form: Oral Tablet
Strengths: 
  • oxycodone hydrochloride 2.5 mg/acetaminophen 325 mg
  • oxycodone hydrochloride 5 mg/acetaminophen 325 mg
  • oxycodone hydrochloride 7.5 mg/acetaminophen 325 mg
  • oxycodone hydrochloride 10 mg/acetaminophen 325 mg
  • oxycodone hydrochloride 5 mg/ acetaminophen 300 mg
  • oxycodone hydrochloride 7.5 mg/acetaminophen 300 mg
  • oxycodone hydrochloride 10 mg/acetaminophen 300 mg
Form: Oral Solution
Strengths: oxycodone hydrochloride 5 mg/acetaminophen 325 mg per 5 ml
Form: Oral extended-release Tablet
Strengths: oxycodone hydrochloride 7.5 mg/acetaminophen 325 mg
Adult Dosage (ages 18-64 years)
  • immediate-release tablets: The dose ranges from oxycodone hydrochloride 2.5 mg/acetaminophen 325 mg to oxycodone hydrochloride 10 mg/acetaminophen 650 mg taken every 6 hours as needed.
  • extended-release tablets: The dose is oxycodone hydrochloride 15 mg/acetaminophen 650 mg taken every 12 hours.
  • The daily maximum doses are:
    • 60 mg of oxycodone hydrochloride
    • 4,000 mg of acetaminophen
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior Dosage (ages 65 years and older)

Your doctor may give you a lowered dose of this medication if you’re older than 65 years. This is because your liver and kidneys may process and remove the drug more slowly from your body. That could cause a build up of the drug in your body, which increases your risk of side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

What to Do If You Miss a Dose

If you’re taking the medication regularly, take the missed dose as soon as you can. Skip the missed dose if it’s almost time for your next scheduled dose.

Don’t use extra medicine to make up the missed dose. This could result in toxic side effects.

How to Tell if the Drug is Working

You may be able to tell the drug is working if you feel less pain after taking it.

Is This a Short-Term or Long-Term Treatment?

How long you take this drug depends on your pain. Your doctor will tell you when and how to stop taking it.

You don’t have to take this medication with food

But if it causes upset stomach, taking it with food may help.

Don’t cut or break the extended-release form

This may cause overdose and death. Swallow the extended-release tablet whole.

Store in temperatures from 59–86°F (15–30°C)

Make sure not to freeze the oral solution.

Keep the medication away from light and high temperatures.

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Airport X-ray machines can’t hurt your medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.

Clinical monitoring

Kidney function: Your doctor may do blood tests to check your kidney function if you have kidney problems.

Liver function: Your doctor may do blood tests to check your liver function if you have liver problems.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this medication.

Are there any alternatives?

There are several drugs that can treat pain. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 1, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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