Drug Interaction Checker

Tacrolimus may be taken with or without food, but it is critical that you always take tacrolimus consistently with or without food to maintain consistent blood levels of this drug. Avoid grapefruit juice while taking Tacrolimus. Grapefruit and Grapefruit juice increase Tacrolimus blood levels significantly leading to side effects like abdominal pain, confusion, decreased urination, dizziness, headache, mood changes, nausea-vomiting, tremor, yellowing of skin or eyes, weakness, or other problems. An interaction with topical Tacrolimus is unlikely.

In roughly 3 to 7 out of every 100 persons using topical tacrolimus (Protopic), drinking alcohol may cause the skin or face to become flushed or red and feel hot. Let your prescriber know if you notice such reactions, particularly if they are bothersome. In some cases, your prescriber can recommend a treatment that might lessen the reaction when you drink alcohol socially. If the reaction is particularly uncomfortable, it may be best to limit your alcohol intake.