Drug Interaction Checker

Certain food or drink such as cola may increase the risk of methotrexate side effects, particularly if you drink high amounts of carbonated beverages or sodas. Tell your doctor if you regularly drink soft drinks. Immediately report any ununsual symptom such as stomach pain, sore throat, fever, mouth sores, or problems with urination.

You may need to follow some dietary instructions while taking this drug to help control bacteria in the urine. This drug requires an acidic urine to be most effective. Certain foods, like milk and most fruits or fruit juices, might interfere with the best action of this drug in preventing urine infections. Ask your prescriber if you should avoid or limit any of these foods in the diet during your treatment. Orange juice and other fruit juices are not helpful at making the urine more acidic.