Severe
ergonovine
+ nicotine
It is recommended to avoid nicotine (examples: Nicotine patches or gum) and tobacco while taking any Ergot-type medications. Side effects from Ergot Alkaloids may get worse if you take Nicotine or if you smoke tobacco. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. Side effects might include anxiety, chest pain, numbness in the fingers or toes, tingling, or vision changes.
Severe
ergonovine
+ efavirenz
Do not take Efavirenz and Ergot Alkaloids together. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. Side effects from these Ergot Alkaloids may get worse if you take Efavirenz. Abdominal pain, anxiety, chest pain, severe nausea and vomiting, numbness, tingling, or vision changes or other serious side effects may occur.
Severe
ergonovine
+ amlodipine-olmesartan
Ergonovine may decrease the actions of drugs used to treat angina or chest pain, like a group of drugs known as Calcium-Channel Blockers. Calcium-channel blockers may be prescribed for many different medical purposes. Examples of Calcium-Channel Blockers sometimes used to treat angina include Adalat, Calan, Cardene, Cardizem, Dilacor, DynaCirc, Isoptin, Norvasc, Plendil, Procardia, Sular, Tiazac, or Verelan. Ergonovine is not typically prescribed to patients who have angina or chest pain. It is possible that Ergonovine may cause chest pain or other heart-related side effects in persons predisposed to these conditions, which may make the Calcium-channel blocker-type drug less effective at treating chest pain.
Severe
ergonovine
+ Grapefruit juice
Taking grapefruit juice with Ergot Alkaloids might increase the risk of nausea, nervousness, chest pain, high blood pressure, palpitations, or other serious side effects, like pain, numbness or reduced circulation to the hands, feet or legs. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. It is best to avoid grapefruit juice while taking Ergot Alkaloids to reduce the chance of Ergot Alkaloid-related side effects.
Severe
ergonovine
+ Tobacco
It is recommended to avoid nicotine (examples: Nicotine patches or gum) and tobacco while taking any Ergot-type medications. Side effects from Ergot Alkaloids may get worse if you take Nicotine or if you smoke tobacco. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. Side effects might include anxiety, chest pain, numbness in the fingers or toes, tingling, or vision changes.
Severe
nicotine
+ Tobacco
Once you begin Nicotine therapy to help you stop smoking or using tobacco products, you should stop using Tobacco. If you continue to use Tobacco while using Nicotine drug products, you may expereince side effects from too much Nicotine, like headache, nausea or vomiting, abdominal pain, or high blood pressure.
Severe
efavirenz
+ methohexital
When Efavirenz is given in combination with Barbiturates (Mysoline, Phenobarbital, Seconal, and others) a complex interaction occurs. Decreased effectiveness of Efavirenz, the Barbiturate, or both may be observed. Side effects may also increase. Notify your health care provider if you notice changes in your infection status, increased drowsiness, decreased seizure control (if you are taking a Barbiturate to treat seizures), or other unusual effects. Do not drive or operate machinery until you know how these drugs affect you.
Severe
isocarboxazid
+ methohexital
Methohexital, a General Anesthetic, is only used in a hospital or clinic during surgery to make you unconscious (sleep) during the procedure. If you are taking a MAOI (MAOIs include drugs like Eldepryl, Emsam, Marplan, Nardil, and Parnate) and receive certain Anesthetics, you may be at increased risk of developing a change in heartbeat, heart rhythm, or blood pressure during or immediately following surgery. Talk to your health care provider before any surgeries or procedures and inform them that you have been taking a MAOI.
Severe
isocarboxazid
+ pentazocine
You should not take Pentazocine and Monoamine oxidase inhibitors (MAOIs) together. MAOIs include Eldepryl, Marplan, Nardil, and Parnate. Side effects from Pentazocine and MAOIs may get worse if you take both of these drugs. The combination may increase the risk of confusion, increased blood pressure or heart rate, loss of coordination, restlessness, sweating, tremor, vomiting, or other serious side effects.
Severe
isocarboxazid
+ Tyramine-containing foods
The following foods can cause sudden blood pressure increases and should also be avoided: aged cheese; yeast extract; protein extract; soy sauce; fava bean or broad bean pods; smoked meats; pickled meats; smoked poultry; pickled poultry; smoked fish (lox, smoked salmon); pickled fish (pickled herring); fermented sausage (bologna, pepperoni, salami, summer sausage); bananas; avocados; any over-ripe fruit. Dietary and beverage restrictions should continue for at least 2 weeks after stopping Rasagiline.
Severe
isocarboxazid
+ Alcohol
Alcohol interactions with MAOIs can be serious and may cause increased blood pressure ('hypertensive crisis') or other effects. MAOIs include drugs such as Azilect, Eldepryl, Emsam, Marplan, Nardil, and Parnate. You must adhere to all dietary restrictions. Alcoholic beverages to avoid include beer; wine; sherry; hard liquor; or liqueurs. Dietary and beverage restrictions should continue for at least 2 weeks after stopping a MAOI.
Severe
isocarboxazid
+ Caffeine-containing Foods/Beverages
Do not take Monoamine Oxidase Inhibitors (also known as MAOIs) and Caffeine together without talking to your health care provider. MAOIs include drugs like Eldepryl, Marplan, Nardil, and Parnate. Food, medicine, and dietary interactions with these MAOIs can be serious. Rapid heartbeats or serious increases in blood pressure, known as "hypertensive crisis", may occur. Try to avoid or limit all preparations containing caffeine such as tea, coffee, chocolate, cola. Do not take nonprescription medicines that contain Caffeine, like "stay awake" or weight loss products, including herbal diet aids. Caffeine restrictions should continue for at least 2 weeks after stopping an MAOI.
Severe
gefitinib
+ methohexital
Although this interaction is possible, these drugs may be used together. Barbiturates (examples: Mysoline, Phenobarbital, Seconal, and others) may decrease the actions of Gefitinib. Your health care provider will closely monitor your response to Gefitinib and will adjust your dose if necessary. Notify your health care provider if you notice increased eye irritation and/or pain, shortness of breath or difficulty breathing, nausea, vomiting, mouth sores, or other unusual effects.
Severe
methohexital
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
pentazocine
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
chlorzoxazone
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
octreotide
+ amlodipine-olmesartan
Although Octreotide (Sandostatin) and Calcium-Channel Blockers (examples: Adalat, Calan, Cardizem, Isoptin, Norvasc, Plendil, and many others) can interact, generally, Octreotide is only used in a hospital or clinic. Both Octreotide and Calcium-Channel Blockers have effects on the heart. Using Octreotide and Calcium-Channel Blockers together can further slow down the heart and/or affect heart rhythm. Your health care provider will closely monitor your condition while receiving these drugs.
Moderate
mifepristone
+ methohexital
Interactions between Mifepristone, RU-486 and General Anesthetics are not thought to be common. General Anesthetics are only used in a hospital or clinic during surgery to make you unconscious (sleep) during the procedure and to decrease pain. If you have a condition for which you are taking Mifepristone, RU-486, the anesthesia, muscle relaxation, and recovery time following surgery may be slightly prolonged. Discuss your drug regimen with your health care provider prior to any surgeries or procedures.
Moderate
mifepristone
+ Grapefruit juice
Mifepristone (also known as RU-486 or Mifeprex) does not interact with most foods. Grapefruit juice and grapefruit-containing foods may increase the effects of Mifepristone, RU-486, which may worsen side effects like abdominal pain, diarrhea, headache, or uterine cramps. Do not significantly alter your grapefruit juice intake while taking this drug.
Moderate
nicotine
+ Acidic food
Most forms of nicotine do not interact significantly with food. If you are using Nicotine Gum, however, you should not ingest acidic beverages like coffee or colas within 15 minutes of chewing the gum, in order to get the best effect of the Nicotine. Also, do not eat or drink while chewing the gum.
Moderate
clopidogrel
+ gefitinib
Using these drugs together may make you bruise or bleed more easily. Although these drugs can interact, Platelet Inhibitors are only used in a hospital or clinic. Your health care provider will closely monitor your condition, adjust your drug treatments, and will watch for signs of bleeding while you are receiving Platelet Inhibitors in the hospital. Signs of bruising or bleeding include, but are not limited to, increased bruising, nosebleeds, bleeding gums, pinpoint red spots on your skin, pinkish-colored or blood-tinged urine, or black, tarry stools. If you notice any of these effects, contact your prescriber immediately.
Moderate
efavirenz
+ gefitinib
Although an interaction is possible, these drugs may be used together. Side effects from Gefitinib may get worse if you take Efavirenz. Notify your health care provider if you notice increased eye irritation and/or pain, shortness of breath or difficulty breathing, nausea, vomiting, sores in mouth, or other unusual effects.
Moderate
efavirenz
+ amlodipine-olmesartan
Side effects from Amlodipine may get worse if you take Efavirenz. If the blood pressure drops too low while taking Amlodipine, you may become dizzy or feel faint. Contact your prescriber if you have dizziness that does not go away. If you check your blood pressure at home and notice a decrease in your blood pressure, contact your health care provider.
Moderate
efavirenz
+ Alcohol
Taking Efavirenz with alcohol-containing drinks can lead to increased side effects. You may experience more severe dizziness, drowsiness, difficulty sleeping or concentrating, and nightmares. Do not drive or operate machinery if you are drinking alcohol-containing beverages.
Moderate
isocarboxazid
+ amlodipine-olmesartan
Monoamine Oxidase Inhibitors or MAOIs (drugs such as Azilect, Eldepryl, Emsam, Marplan, Nardil, and Parnate) and Calcium Channel Blockers (medicines to treat high blood pressure) should be used together with caution. Combining these medicines may cause a large or sudden drop in blood pressure which may result in dizziness or falls. If taking these medicines together is necessary, your blood pressure should be monitored, especially when therapy is first started or during a dose change. Notify your prescriber if you experience dizziness, faintness, or low blood pressure readings while taking this combination.
Moderate
isocarboxazid
+ amlodipine-olmesartan
These drugs must be used together with caution. Combining Monoamine oxidase inhibitors and Angiotensin II receptor antagonists (such as Cozaar, Benicar, Micardis, or Diovan) may cause a large or unexpected drop in blood pressure. If these medicines must be taken together, make sure your blood pressure is monitored regularly. In addition to monitoring blood pressure readings, report any symptoms of low blood pressure to your doctor such as dizziness, faintness, or increased heart rate.
Moderate
probenecid
+ valacyclovir
Side effects from Valacyclovir may get worse if you take Probenecid; however this may only be significant if you have decreased kidney function. If you experience confusion, tremor, decreased urination, or other unusual reactions, contact your health care provider.
Moderate
gefitinib
+ Grapefruit juice
Grapefruit juice and grapefruit-containing foods may increase the side effects of Gefitinib. Do not significantly alter grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible. Notify your health care provider if you notice increased eye irritation and/or pain, shortness of breath or difficulty breathing, nausea, vomiting, mouth sores, or other unusual effects.
Moderate
zinc acetate
+ Food
Taking oral Zinc Salts (dietary supplements or medicines like Galzin, Zinc Sulfate, etc.) at the same time as food or beverages, other than water, can reduce the amount of zinc absorbed. Breads, vegetables, fruits, eggs, and beverages like milk or coffee are all known to decrease zinc supplement absorption. If you do take a Zinc supplement, it is best to take it at least 1 hour before or 1 hour after you have taken any feeding, meal, or beverage.
Moderate
methohexital
+ amlodipine-olmesartan
Barbiturates (examples: Mysoline, Phenobarbital, and Seconal) can decrease the actions of Amlodipine, by increasing its elimination from the body. Although an interaction is possible, these drugs may be used together. If you check your blood pressure at home and notice a significant increase in your blood pressure while taking Amlodipine, contact your health care provider.
Moderate
methohexital
+ amlodipine-olmesartan
Although these drugs interact, Methohexital is only used in a hospital or clinic during major surgery or electroconvulsive therapy (ECT). Although these drugs are often used together, do not stand or sit up too quickly after receiving Methohexital as you may become dizzy or feel faint. Do not drive or operate machinery until you know how these drugs affect you. Discuss your drug regimen with your health care provider prior to any surgeries or procedures.
Moderate
methohexital
+ pentazocine
You may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
methohexital
+ chlorzoxazone
You may feel dizzy, drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, difficulty breathing, or other unusual effects, contact your health care provider immediately.
Moderate
amlodipine-olmesartan
+ Alcohol
Although an interaction is possible, Ethanol (alchohol) and Antihypertensive Agents (drugs used to reduce high blood pressure) may be used together. Ethanol or alchohol-containing beverages may increase the effects of Antihypertensive Agents on your blood pressure. If the blood pressure drops too low while taking Ethanol and Antihypertensive Agents, you may become dizzy or feel faint. To limit this interaction, avoid alcohol-containing beverages while taking medicines to lower your blood pressure. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Moderate
pentazocine
+ chlorzoxazone
Although an interaction is possible, these drugs are sometimes used together. You may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
pentazocine
+ Tobacco
Tobacco smoking may reduce the effectiveness of Pentazocine at treating pain, by speeding the removal of the drug from the body. Alternatively, if you take Pentazocine and suddenly stop smoking, you may feel drowsy or more tired, and should not drive or operate machinery until you know how Pentazocine affects you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing while taking Pentazocine, contact your health care provider immediately.
Minor
mifepristone
+ clopidogrel
Although an interaction is possible, these drugs are often used together without problems. In theory, Mifepristone, RU-486 may decrease the actions of Clopidogrel to some extent. The significance of this interaction is not known.
Minor
mifepristone
+ gefitinib
In theory, the risk of side effects from Gefitinib may increase if you take Mifepristone (RU-486). Although an interaction is possible, these drugs may be used together with caution. Notify your health care provider if you notice increased eye irritation and/or pain, shortness of breath or difficulty breathing, nausea, vomiting, sores in mouth, or other unusual effects.
Minor
mifepristone
+ amlodipine-olmesartan
Side effects from Calcium-Channel Blockers (examples: Adalat, Calan, Cardizem, Isoptin, Norvasc, Plendil, and many others) might get worse if you take Mifepristone (also known as RU-486 or Mifeprex). Mifeprex can decrease the elimination of Calcium-Channel Blockers from the body. If your heart rate or blood pressure drops too low while taking a Calcium-Channel Blocker, you may become dizzy or feel faint; do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away or if you notice new or increased swelling of your legs or ankles.
Minor
clopidogrel
+ efavirenz
Although an interaction is possible, these drugs are often used together without problems. In theory, Efavirenz may affect the actions of Clopidogrel to some extent. The significance of this interaction is not known. Discuss any new or worsening side effects with your health care provider.
Minor
clopidogrel
+ methohexital
In theory, side effects from Clopidogrel may get worse if you take Barbiturates (phenobarbital, primidone). Side effects of Clopidogrel may include diarrhea or stomach pain or stomach upset (heartburn). Discuss any new or worsening side effects with your health care provider.
Minor
efavirenz
+ solifenacin
Although an interaction is possible, these drugs may be used together. Discuss any new or worsening side effects (like confusion, constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, palpitations, or fast heartbeat) with your health care provider. In some individuals, lower doses of Solifenacin may need to be prescribed, check with your health care professional.
Minor
probenecid
+ Alcohol
Avoid or minimize your intake of alcohol while taking Probenecid. Probenecid is used to prevent gout attacks. Gout is caused by too much uric acid in the blood. Alcohol can cause an increase in the blood levels of uric acid and decrease the actions of Probenecid. Let your health care provider know immediately if you have a gout attack. Your medications may need to be adjusted.
Minor
zinc acetate
+ Enteral Feedings
If you need to use Enteral feedings (examples: Ensure, Jevity and others) as your sole nutritional dietary intake for long periods of time, you may be at risk for Zinc deficiency, as the feeding may impair the absorption of zinc. This interaction is not a concern if you simply use these products as supplements to a normal diet; true zinc deficiency is relatively rare. If you take Enteral Feedings as your only diet for long periods of time, you may need to discuss the use of additional mineral supplements with your prescriber. If you do take a Zinc supplement, it is best to take it at least 1 hour before or 1 hour after you have taken any feeding, meal, or beverage.
Minor
solifenacin
+ Grapefruit juice
Solifenacin may be administered with or without food; most foods do not interact. Side effects from Solifenacin may get worse if you take grapefruit juice. Do not significantly alter your intake of grapefruit or grapefruit juice while taking Solifenacin. In addition, excessive intake of beverages with caffeine or alcoholic beverages may increase urination and may decrease the effectiveness of Solifenacin.
Minor
solifenacin
+ Alcohol
The intake of Alcoholic beverages may decrease the actions of Solifenacin because Alcohol may increase urination. You may wish to limit your intake of Alcoholic beverages while taking Solifenacin. Do not drive or operate machinery until you know how these drugs affect you.
Minor
solifenacin
+ Caffeine-containing Foods/Beverages
Solifenacin may be administered with or without food; most foods do not interact. Side effects from Solifenacin may get worse if you take grapefruit juice. Do not significantly alter your intake of grapefruit or grapefruit juice while taking Solifenacin. In addition, excessive intake of beverages with caffeine or alcoholic beverages may increase urination and may decrease the effectiveness of Solifenacin.
Minor
methohexital
+ Caffeine-containing Foods/Beverages
Barbiturates are commonly used for sedation, seizures or for sleep and include drugs like Amytal, Buticaps, Mysoline, Nembutal, Phenobarbital, and Seconal. Caffeine may cause sleeplessness, so if you are taking a barbiturate to help you sleep, you may wish to avoid taking caffeine and caffeine-containing foods like colas, coffee, teas, or chocolates within several hours prior to bedtime. Barbiturates may also decrease the actions of Caffeine; if you have a high intake of caffeinated foods or beverages you may experience a headache or irritability from decreased caffeine levels while taking these drugs until your body adjusts. If you take Caffeine for other purposes, notify your health care provider if you think Caffeine is not working as well for you.
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