Drug Interaction Checker

In general, the combination of Bupropion (Wellbutrin or Zyban) with Nicotine (found in Tobacco) may increase the risk of high blood pressure, so avoid smoking Tobacco while taking Bupropion. If you are taking Bupropion (Zyban) to help you stop smoking, you should pick a date to stop Tobacco smoking by the second week of your Bupropion treatment. Some people are prescribed a combination of Bupropion (Zyban) with Nicotine replacement therapy (like Nicotine patches) to stop smoking; in this case you should stop Tobacco smoking before you start using the Nicotine treatment.

Side effects from Bupropion may get worse if you consume large quantities of caffeine. Side effects such as nervousness, irritability, sleeplessness, increased blood pressure, seizures and other side effects may get worse if you take Bupropion and Caffeine together. Try to limit Caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements).