Severe
albuterol
+ epinephrine
While you take Albuterol, use Sympathomimetic drugs with caution because additive side effects may occur. Examples of Sympathomimetics include stimulants like Amphetamine, Adderall, Dexedrine, Ephedrine, Fastin, and Tenuate; some cough and cold products containing Pseudoephedrine (example Sudafed), Phenylephrine, or Phenylpropanolamine (PPA); and also herbal weight loss products containing ephedra or Ma huang. Taking the listed drugs with Albuterol can increase the risk of a fast heart rate, nervousness, palpitations, problems with sleep, or other side effects.
Severe
propoxyphene
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
clemastine
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
epinephrine
+ ergotamine
Although Epinephrine and Ergot Alkaloids can interact, generally, Epinephrine is only used in for emergency purposes, such as self-treatment of a life-threatening allergic reaction, or in a hospital or clinic. In general, do not take Epinephrine and Ergot Alkaloids (examples include Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine) together in other situations. Taking Epinephrine with Ergot alkaloids can increase the risk of chest pain, high blood pressure, palpitations, or other serious side effects.
Severe
ramelteon
+ Grapefruit juice
Do not take Ramelteon with grapefruit or grapefruit juice. Taking Ramelteon with grapefruit or grapefruit juice can increase the amount of Ramelteon in the blood and can increase the risk of serious side effects. Swallow Ramelteon with some water within 30 minutes before you are ready to go to bed. Tell your health care professional if your sleep problem does not improve or gets worse.
Severe
ramelteon
+ Alcohol
Avoid alcoholic drinks while you are taking Ramelteon. Using Ramelteon with alcohol can lead to serious side effects. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
ramelteon
+ Tobacco
Tobacco smoke contains substances that may speed the removal of Ramelteon from the body; if you start smoking, Ramelteon may become less effective. Just the opposite occurs when someone stops smoking tobacco; if you stop smoking, the amount of Ramelteon in the blood may increase. Tell your health care professional if you smoke or plan to stop smoking while taking Ramelteon.
Severe
frovatriptan
+ ergotamine
Avoid the combined use of these drugs within 24 hours of one another. Serious side effects from Serotonin-Receptor Agonists ("Triptans" or drugs used for migraine like Amerge, Axert, Imitrex, Maxalt, Relpax and Zomig) may get worse if you take Ergot Alkaloid related drugs. Taking these two drugs together could potentially lead to chest pain, confusion, loss of coordination, restlessness, sweating, tremor or other side effects. Ask your prescriber about the best approach should you need migraine therapy with a "Triptan" while taking Ergot Alkaloids.
Severe
triamterene
+ potassium iodide
Do not take Potassium Salts and Potassium-sparing diuretics (examples: Moduretic, Spironolactone, Aldactone, Aldactazide, Maxide, Dyazide, Dyrenium) together without talking to your health care provider. Potassium-sparing diuretics may increase the amount of potassium in your blood. High potassium levels may cause muscle weakness, or an abnormal heart rhythm. If you experience extreme muscle weakness, chest pain, pounding heartbeat, or an unusually fast or slow heart beat, contact your health care provider immediately. While taking these drugs together, your prescriber may order a blood test to check the level of potassium in your blood. DO NOT take potassium supplements unless they are prescribed for you by your health care provider. Discuss any other medicines or dietary supplements that you are taking with your health care provider.
Severe
ergotamine
+ Grapefruit juice
Taking grapefruit juice with Ergot Alkaloids might increase the risk of nausea, nervousness, chest pain, high blood pressure, palpitations, or other serious side effects, like pain, numbness or reduced circulation to the hands, feet or legs. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. It is best to avoid grapefruit juice while taking Ergot Alkaloids to reduce the chance of Ergot Alkaloid-related side effects.
Severe
ergotamine
+ Tobacco
It is recommended to avoid nicotine (examples: Nicotine patches or gum) and tobacco while taking any Ergot-type medications. Side effects from Ergot Alkaloids may get worse if you take Nicotine or if you smoke tobacco. Ergot Alkaloids include, but are not limited to, Cafergot, Ergotrate, Ergostat, Hydergine, Methergine, Migranal, Sansert or Wigraine. Side effects might include anxiety, chest pain, numbness in the fingers or toes, tingling, or vision changes.
Severe
pyrazinamide
+ Alcohol
Drinking alcohol beverages while taking Pyrazinamide, PZA can increase your risk of developing liver problems. It is best to avoid alcohol-containing beverages while taking Pyrazinamide, PZA. Your health care provider will need to do blood tests to check your liver before and during your treatment with Pyrazinamide, PZA. Discuss any new or worsening side effects, such as stomach pain, nausea, vomiting, dark colored urine, or yellowing of eyes or skin, with your health care provider.
Severe
potassium iodide
+ Foods high in potassium
Do not take Potassium Salts (such as K-Dur, Micro-K, and others) together with salt substitutes or low salt milk products which contain potassium. Taking salt substitutes or other potassium-containing products with this medicine can increase the level of potassium in the blood. If the potassium level is too high, you may experience muscle weakness or an abnormal heart rhythm. If you experience extreme muscle weakness, chest pain, pounding heartbeat, or an unusually fast or slow heart beat, contact your health care provider immediately. While taking Potassium-containing medicines, your prescriber may order a blood test to check the level of potassium in your blood. DO NOT take potassium-containing nutritional supplements with this medicine unless they are approved for you by your health care provider.
Severe
nabilone
+ Alcohol
Avoid alcoholic beverages while taking Nabilone. Alcohol may increase the risk of side effects. Decreased alertness, dizziness, drowsiness, falls, or other side effects may occur. Do not drive or operate machinery if you are drinking alcohol-containing beverages.
Severe
zolpidem extended release
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
acetaminophen-dextromethorphan
+ Alcohol
Patients who drink more than 3 alcoholic drinks a day and take acetaminophen are at increased risk of developing liver side effects. Avoid alcoholic drinks if you are taking acetaminophen on a regular basis.
Moderate
albuterol
+ fluticasone
Side effects from Pirbuterol may get worse if you take Corticosteroids. Although an interaction is possible, these drugs are often used together. Your health care provider may need to monitor your potassium levels with a blood test. Discuss any new or worsening side effects with your health care provider.
Moderate
albuterol
+ Caffeine-containing Foods/Beverages
Limit excessive Caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Sympathomimetics and avoid medicines containing additional Caffeine whenever possible. Examples of Sympathomimetics include medicines used to treat asthma and other breathing problems like Albuterol, Arformoterol, Formoterol, Salmterol and others. Taking a high amount of Caffeine with the listed drugs can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects.
Moderate
propoxyphene
+ clemastine
You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing while taking these drugs, contact your health care provider immediately.
Moderate
propoxyphene
+ tamsulosin
Propoxyphene may increase the actions of Tamsulosin and potentially increase its side effects. If the blood pressure drops too low while taking these medications, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. Contact your prescriber if you have dizziness that does not go away.
Moderate
propoxyphene
+ nabilone
These drugs must be used together with caution. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. Discuss any new or worsening side effects, such as confusion, difficulty staying alert, dizziness, hallucinations, or changes in mood, with your health care provider.
Moderate
propoxyphene
+ zolpidem extended release
You may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
propoxyphene
+ Tobacco
Tobacco smoking may reduce the effectiveness of Propoxyphene at treating pain, by speeding the removal of Propoxyphene from the body. Alternatively, if you take Propoxyphene e and suddenly stop smoking, you may feel drowsy or more tired, and should not drive or operate machinery until you know how Propoxyphene affects you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing while taking Propoxyphene, contact your health care provider immediately.
Moderate
clemastine
+ ramelteon
You may feel drowsy or more tired when taking Anxiolytics, Sedatives, and Hypnotics with Sedating H1 blockers. Do not drive or operate machinery until you know how these drugs affect you.
Moderate
clemastine
+ nabilone
You may feel drowsy or more tired when taking Nabilone and Antihistamines together. You may also experience an increase in heart palpitations if these drugs are taken together. Antihistamines are found in many allergy, cough, and hay fever products (examples: Benadryl, Dimetapp Allergy, Tavist Allergy, Zyrtec, and others). Many non-prescription cough and cold products may contain Antihistamines; carefully read labels. Do not drive or operate machinery until you know how these drugs affect you.
Moderate
clemastine
+ zolpidem extended release
You may feel drowsy or more tired when taking Anxiolytics, Sedatives, and Hypnotics with Sedating H1 blockers. Examples of Anxiolytics, Sedatives, and Hypnotics include Sonata, Valium, Ativan, Klonopin, Ambien, BuSpar, Remeron, and many others. Do not drive or operate machinery until you know how these drugs affect you.
Moderate
cefixime
+ gentamicin
Cephalosporins have caused kidney problems when mixed with aminoglycosides (Garamycin, Nebcin) which are known to cause kidney problems in some people.
Moderate
alprostadil
+ triamterene
Alprostadil may increase the actions of Antihypertensive Agents. Antihypertensive Agents are drugs used to treat high blood pressure. If the blood pressure drops too low while taking these medications, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Moderate
epinephrine
+ nabilone
Discuss with your health care provider before taking Nabilone with Lisdexamfetamine. Taking these drugs together can increase the risk of high blood pressure, nervousness, palpitations, problems with sleep, or other serious side effects.
Moderate
epinephrine
+ Caffeine-containing Foods/Beverages
Limit excessive Caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Epinephrine and avoid medicines containing additional Caffeine whenever possible. Taking a high amount of Caffeine with Epinephrine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects.
Moderate
ramelteon
+ nabilone
These drugs must be used together with caution. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. Discuss any new or worsening side effects, such as confusion, difficulty staying alert, dizziness, hallucinations, or changes in mood, with your health care provider.
Moderate
ramelteon
+ zolpidem extended release
These drugs must be used together with caution. Because some of these drugs are duplicate therapies and may increase the risk of side effects, do not take Ramelteon and other drugs used for sleep (examples: Chloral Hydrate, Dalmane, Doral, Halcion, Prosom, Restoril, Seconal or Sonata) together without talking to your health care provider. Generally it is recommended that you do not take two drugs for sleep together. Anxiolytic drugs (drugs used for anxiety or nerves) are sometimes used together with drugs used for sleep. However, you may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
ramelteon
+ High Fat Foods
Taking Ramelteon with food, especially a high fat meal, or immediately after eating may prevent Ramelteon from working. Swallow Ramelteon with some water within 30 minutes before you are ready to go to bed. Tell your health care professional if your sleep problem does not improve or gets worse.
Moderate
sodium bicarbonate
+ Food
Avoid taking Sodium Bicarbonate with foods or beverages which contain a high sodium content (such as tomato juice or processed foods). Sodium Bicarbonate contains a significant amount of sodium in the oral solution. Talk to your health care provider about any dietary restrictions which are important in improving your health conditions.
Moderate
frovatriptan
+ acetaminophen-dextromethorphan
Side effects from Serotonin-Receptor Agonists may get worse if you take Dextromethorphan at the same time. Try to avoid use at the same time if possible. Taking these drugs together may increase the risk of restlessness, sweating, tremor, vomiting, or other side effects. Do not exceed recommended doses of cough products containing Dextromethorphan, and report any troublesome effects that occur.
Moderate
triamterene
+ fluticasone
Using these drugs together may lower the level of potassium in your blood. When the potassium in the blood is too low, this can cause muscle cramps, weakness, or an abnormal heart rhythm. Your health care provider may monitor your potassium level. A potassium supplement may be prescribed for patients with a low potassium level. Skin products containing Betamethasone should not interact.
Moderate
triamterene
+ Alcohol
Although an interaction is possible, Ethanol (alchohol) and Antihypertensive Agents (drugs used to reduce high blood pressure) may be used together. Ethanol or alchohol-containing beverages may increase the effects of Antihypertensive Agents on your blood pressure. If the blood pressure drops too low while taking Ethanol and Antihypertensive Agents, you may become dizzy or feel faint. To limit this interaction, avoid alcohol-containing beverages while taking medicines to lower your blood pressure. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Moderate
fluticasone
+ testosterone
Although an interaction is possible, these drugs are sometimes used together. Notify your prescriber if you notice fluid retention in your ankles, feet, or legs, or if rapid weight gain occurs.
Moderate
tamsulosin
+ Alcohol
Although an interaction is possible, Ethanol (alchohol) and Antihypertensive Agents (drugs used to reduce high blood pressure) may be used together. Ethanol or alchohol-containing beverages may increase the effects of Antihypertensive Agents on your blood pressure. If the blood pressure drops too low while taking Ethanol and Antihypertensive Agents, you may become dizzy or feel faint. To limit this interaction, avoid alcohol-containing beverages while taking medicines to lower your blood pressure. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Moderate
tamsulosin
+ Grapefruit juice
Grapefruit juice may increase the actions of Tamsulosin and potentially increase its side effects. If the blood pressure drops too low while taking tamsulosin, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. You should also limit or avoid grapefruit juice while taking Tamsulosin. Contact your prescriber if you have dizziness that does not go away.
Moderate
nabilone
+ zolpidem extended release
These drugs must be used together with caution. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. Discuss any new or worsening side effects, such as confusion, difficulty staying alert, dizziness, hallucinations, or changes in mood, with your health care provider.
Moderate
acetaminophen-dextromethorphan
+ Tobacco
If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.
Minor
isotretinoin
+ fluticasone
Although an interaction is possible, these drugs are sometimes used together. Both Isotretinoin and Corticosteroids (examples: Decadron, Deltasone, Medrol, or Aristocort) can cause bone loss with long term use. Bone loss can lead to problems such as osteoporosis. It is not known if taking these drugs together for a long time would have additive effects on the bone. If you have to take either of these drugs for a long time, your health care provider will monitor for signs of bone loss or the need for bone loss prevention.
Minor
isotretinoin
+ Alcohol
Avoid or limit alcoholic drinks while taking Isotretinoin. Side effects from Isotretinoin may get worse if you also drink alcohol-containing beverages while taking Isotretinoin therapy. In addition, alcohol may alter the results of blood test done to monitor Isotretinoin therapy; avoid alcoholic drinks for at least 36 hours before any orderd blood test.
Minor
capecitabine
+ fluticasone
Although an interaction is possible, these drugs are often used together. Additive benefits may occur when Corticosteroids (examples: Dexamethasone, Methylprednisolone, Prednisone, or Prednisolone) and Antineoplastic Agents (chemotherapy, medicine used to treat cancer and other conditions) are used together. The combined therapies are often designed to take advantage of these benefits. However, some side effects may include an increased risk of infection. If you notice signs or symptoms of an infection, such as a fever, sore throat, etc., do not treat yourself and seek your prescriber's evaluation and advice.
Minor
capecitabine
+ Food
Capecitabine should be taken with food.
Minor
sodium bicarbonate
+ ascorbic acid
Aluminum Hydroxide may decrease the actions of Ascorbic Acid, Vitamin C.
Minor
sodium bicarbonate
+ acetaminophen-dextromethorphan
Although an interaction is possible, these drugs are often used together. If you take Acetaminophen with Antacids (examples: Amphogel, Gaviscon, Maalox, Tums, Mylanta, and other products used for heartburn), then it may take longer for acetaminophen to work for you. Avoid taking Acetaminophen and Antacids at the same time.
Minor
fluticasone
+ potassium iodide
Although an interaction is possible, these drugs are often used together. Although an interaction is possible, Corticosteroids and Potassium Salts are often used together. Taking Potassium Salts and Corticosteroids together can occasionally increase the level of potassium in the blood. If the potassium level is too high, you may experience muscle weakness or an abnormal heart rhythm. If you experience extreme muscle weakness, chest pain, pounding heartbeat, or an unusually fast or slow heart beat, contact your health care provider immediately. While taking Potassium Supplements, your prescriber may order a blood test to check the level of potassium in your blood. DO NOT take other potassium supplements unless they are prescribed for you by your health care provider.
Minor
zolpidem extended release
+ Caffeine-containing Foods/Beverages
Caffeine is a stimulant and may keep you awake when taken at night. Avoid Caffeine-containing beverages or products prior to going to bed since Caffeine can decrease the ability of Zolpidem to help you sleep.
Minor
acetaminophen-dextromethorphan
+ Grapefruit juice
Grapefruit juice may increase the actions of Dextromethorphan. Side effects from the Dextromethorphan may get worse if you drink grapefruit juice. It may be best to avoid drinking grapefruit juice while you are taking Dextromethorphan.
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