Severe
bicalutamide
+ nelfinavir
The interaction between Anti-retroviral Protease Inhibitors (examples: Agenerase, Crixivan, Fortovase, Invirase, Kaletra-TM, Norvir, and Viracept-TM) and Bicalutamide is complex. Substances which are potent inhibitors of the elimination of Bicalutamide may increase Bicalutamide concentrations, and therefore, increase potential for side effects. Side effects or increased toxicity associated with Bicalutamide may be observed. Notify your health care provider if you notice changes in your infection status or other unusual effects.
Severe
iron polysaccharide
+ aluminum hydroxide-magnesium hydroxide
Antacids (examples: Amphogel, Gaviscon, Maalox, Tums, and other products used for heartburn) can decrease the absorption of Iron from the stomach. Therefore, Antacids can decrease the effectiveness of Iron Salts (examples: Femiron, Feratab, Nephro-Fer, Slow FE). Avoiding taking these drugs together; wait at least 4 hours between doses of Iron Salts and Antacids.
Severe
iron polysaccharide
+ Food
Specific food or beverages including dairy products (such as cheese, milk, yogurt, or cottage cheese), coffee, or tea can decrease the absorption of Iron from the stomach. To limit this interaction, take Iron Salts (examples: Femiron, Feratab, Nephro-Fer, Slow FE) at least 1 hour before or 2 hours after meals. If stomach upset occurs, Iron Salts may be given with meals. However, where possible, avoid coffee, tea, or dairy products within 1 hour before or 2 hours after taking any Iron product. Taking these food together while taking Iron Salts can decrease the effectiveness to increase the amount of Iron in the body. In addition, Enteral Feedings (liquid nutritional feedings such as Ensure, Isocal, Jevity and others) are not recommended to be given within the 1 hour before and 1 hour after giving Ferrous Sulfate Elixir (example: Feosol Elixir). There does not appear to be an interaction with other liquid Iron products.
Severe
cefditoren
+ aluminum hydroxide-magnesium hydroxide
Antacids (Alu-Cap, Amphojel, Maalox, Mylanta) may decrease the amount of Cefditoren absorbed by the stomach, which can decrease its effects in the body. To limit this interaction, take Cefditoren at least 2 hours before or after you take Antacids.
Severe
atropine
+ APAP/chlorpheniramine/dextromethorphan/PSE
Do not take Atropine and Pseudoephedrine products together without talking to your health care provider. Atropine may increase the actions of Pseudoephedrine to increase blood pressure. Contact your prescriber if you notice an increase in your blood pressure or palpitations while taking Pseudoephedrine and Atropine together.
Severe
pimozide
+ nelfinavir
Do not take Pimozide and Anti-retroviral protease inhibitors (drugs used to treat HIV infection) together. Taking these drugs together can increase the risk of a dangerous change in heartbeat or heart rhythm; you may experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat).
Severe
pimozide
+ disopyramide
Do not take Pimozide and Disopyramide together. Taking these drugs together can increase the risk of a dangerous change in heartbeat or heart rhythm; you may experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat).
Severe
pimozide
+ Grapefruit juice
Avoid Grapefruit and Grapefruit juice while taking Pimozide. Serious side effects (a dangerous change in heartbeat or heart rhythm) from Pimozide may get worse if you take Grapefruit or Grapefruit juice. Contact your prescriber immediately if you experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (such as a fast or irregular heart beat).
Severe
pimozide
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Severe
nelfinavir
+ disopyramide
Do not take Disopyramide and Nelfinavir together without talking to your health care provider. These drugs may be used together with great caution and with close observation by your health care provider. Taking these drugs together might increase the risk of a dangerous change in heartbeat or heart rhythm; you may experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your heart beat (usually a fast or irregular heart beat). Notify your health care provider immediately if any of these symptoms occur.
Severe
linezolid
+ APAP/chlorpheniramine/dextromethorphan/PSE
Use caution when taking Dextromethorphan and Linezolid together. Taking Linezolid with Dextromethorphan might increase the risk of restlessness, sweating, tremor, vomiting, or other side effects; however, this interaction is not thought to be common in short-term use of these drugs. Many non-prescription products contain Dextromethorphan and other ingredients that might interact with Linezolid; read labels closely before taking any medicine. If you experience any unusual effects while taking these drugs together, contact your health care provider.
Severe
linezolid
+ APAP/chlorpheniramine/dextromethorphan/PSE
Do not take Linezolid and Sympathomimetics together. Examples of Sympathomimetics include stimulants or weight loss drugs like Amphetamine, Adderall, Dexedrine, Didrex, Fastin, and Tenuate. Sympathomimetics also include some cough and cold products containing Pseudoephedrine (example Sudafed), Phenylephrine, or Phenylpropanolamine (PPA) and also herbal weight loss products containing ephedra or Ma huang. Using Linezolid with any of the listed drugs might lead to serious increased blood pressure, known as 'hypertensive crisis', nervousness, palpitations or other serious side effects.
Severe
linezolid
+ Tyramine-containing foods
Certain foods containing tyramine might increase the risk of side effects with Linezolid. You should probably limit your intake of alcoholic beverages, aged or smoked meats (like sausages or smoked or pickled fish), aged cheeses, and caffeine containing foods like coffee, colas, teas, and chocolate while on Linezolid. Taking these foods along with Linezolid might increase the risk of increased blood pressure, confusion, restlessness, or other side effects. Ask your dietician or health care professional for a complete listing of foods best avoided while on Linezolid.
Severe
disopyramide
+ Grapefruit juice
Avoid taking Disopyramide with grapefruit juice. Grapefruit juice and grapefruit-containing foods may increase the chance of side effects due to Disopyramide. Contact your prescriber immediately if you experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat) while taking Disopyramide.
Severe
budesonide
+ aluminum hydroxide-magnesium hydroxide
Antacids should be withheld or avoided in patients requiring oral budesonide (Entocort EC) therapy. Examples of Antacids include Amphogel, Gaviscon, Maalox, Tums, Mylanta and other products for heartburn. Antacids may alter the protective coating on the outside of Entocort EC and may affect absorption from your intestine. Nasal or inhaled forms of budesonide (Rhinocort, Pulmicort) are not likely to be affected by this interaction. If you must take these drugs together, take oral budesonide 1 hour before or 4 hours after you take the Antacid; however, even separating the doses may not prevent the interaction.
Severe
budesonide
+ Grapefruit juice
Grapefruit juice can increase the amount of oral Budesonide (Entocort-EC) that your body absorbs. Grapefruit juice and grapefruit-containing foods may increase the side effects of oral Budesonide. If possible, you should avoid grapefruit or grapefruit juice while taking Entocort-EC. At the very least, avoid large changes (i.e., either increases or decreases) in your daily intake of grapefruit and grapefruit juice. Grapefruit juice is not expected to interact significantly with inhaled or nasal Budesonide (Pulmicort or Rhinocort).
Severe
APAP/chlorpheniramine/dextromethorphan/PSE
+ Alcohol
Patients who drink more than 3 alcoholic drinks a day and take acetaminophen are at increased risk of developing liver side effects. Avoid alcoholic drinks if you are taking acetaminophen on a regular basis.
Severe
APAP/chlorpheniramine/dextromethorphan/PSE
+ Alcohol
Avoid alcohol-containing drinks while taking medicines that cause drowsiness like prescription pain medicines, medications to reduce anxiety, medicines to induce sleep or sedation, and medicines used for colds or allergies. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
mannitol
+ corticotropin
Using these drugs together may lower the level of potassium in your blood. When the potassium in the blood is too low, this can cause muscle cramps, weakness, or an abnormal heart rhythm. Your health care provider may monitor your potassium level. A potassium supplement may be prescribed for patients with a low potassium level. Also, use of Corticotropin, ACTH and Mannitol may increase the amount of sodium in your blood. If you will get both Corticotropin, ACTH and Mannitol, ask your health care professional about the need to check your sodium level.
Moderate
mannitol
+ budesonide
Using these drugs together may lower the level of potassium in your blood. When the potassium in the blood is too low, this can cause muscle cramps, weakness, or an abnormal heart rhythm. Your health care provider may monitor your potassium level. A potassium supplement may be prescribed for patients with a low potassium level. Also, use of Corticotropin, ACTH and Mannitol may increase the amount of sodium in your blood. If you will get both Corticotropin, ACTH and Mannitol, ask your health care professional about the need to check your sodium level.
Moderate
mannitol
+ aluminum hydroxide-magnesium hydroxide
Depending on the Diuretic (water pill) you are taking, Diuretics may increase or decrease the actions of Magnesium Salts. Although an interaction is possible, these drugs may be used together. If needed, your prescriber can order a blood test to check the level of Magnesium in the blood.
Moderate
sumatriptan
+ linezolid
Use caution in combining Linezolid (Zyvox, an Antibiotic) and Serotonin-Receptor Agonists (sometimes referred to as 'triptans' which are drugs used to treat migraine headaches). Examples of Serotonin-Receptor Agonists include Axert-TM, Amerge, Maxalt, Imitrex, Relpax and Zomig. The use of these drugs together should be avoided when possible. In certain circumstances, the use of Linezolid with these drugs might be medically necessary. However, you should be alert for interactions. Interactions have been reported with similarly acting drugs and Linezolid. Taking these drugs together could result in serious side effects such as chest pain, chest tightness or pressure, confusion, dizziness, drowsiness, excessive dry mouth, excessive nausea/vomiting, fever, loss of coordination, muscle twitching or weakness, sweating, tremor, and/or palpitations. Report these and any other troublesome side effects immediately.
Moderate
sumatriptan
+ APAP/chlorpheniramine/dextromethorphan/PSE
Side effects from Serotonin-Receptor Agonists may get worse if you take Dextromethorphan at the same time. Try to avoid use at the same time if possible. Taking these drugs together may increase the risk of restlessness, sweating, tremor, vomiting, or other side effects. Do not exceed recommended doses of cough products containing Dextromethorphan, and report any troublesome effects that occur.
Moderate
almotriptan
+ linezolid
Use caution in combining Linezolid (Zyvox, an Antibiotic) and Serotonin-Receptor Agonists (sometimes referred to as 'triptans' which are drugs used to treat migraine headaches). Examples of Serotonin-Receptor Agonists include Axert-TM, Amerge, Maxalt, Imitrex, Relpax and Zomig. The use of these drugs together should be avoided when possible. In certain circumstances, the use of Linezolid with these drugs might be medically necessary. However, you should be alert for interactions. Interactions have been reported with similarly acting drugs and Linezolid. Taking these drugs together could result in serious side effects such as chest pain, chest tightness or pressure, confusion, dizziness, drowsiness, excessive dry mouth, excessive nausea/vomiting, fever, loss of coordination, muscle twitching or weakness, sweating, tremor, and/or palpitations. Report these and any other troublesome side effects immediately.
Moderate
almotriptan
+ APAP/chlorpheniramine/dextromethorphan/PSE
Side effects from Serotonin-Receptor Agonists may get worse if you take Dextromethorphan at the same time. Try to avoid use at the same time if possible. Taking these drugs together may increase the risk of restlessness, sweating, tremor, vomiting, or other side effects. Do not exceed recommended doses of cough products containing Dextromethorphan, and report any troublesome effects that occur.
Moderate
scopolamine
+ disopyramide
Although an interaction is possible, these drugs are sometimes used together. Side effects from Disopyramide may get worse if you take Antimuscarinics (examples: Atrovent, Cogentin, Cystospaz, Detrol, Ditropan, Levbid, Levsin, Transderm Scop). You may feel drowsy or more tired when taking these drugs together. Discuss any new or worsening side effects, such as constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast or slow heartbeat, or confusion, with your health care provider.
Moderate
scopolamine
+ aluminum hydroxide-magnesium hydroxide
Aluminum Hydroxide may decrease the absorption of Antimuscarinics (examples: Atrovent, Cogentin, Cystospaz, Detrol, Ditropan, Levbid, Levsin) from your stomach if taken at the same time. Take these drugs 1-2 hours before or after you take Aluminum Hydroxide to limit any interaction.
Moderate
scopolamine
+ APAP/chlorpheniramine/dextromethorphan/PSE
You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. In addition, you may experience other side effects including constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast heartbeat, or confusion.
Moderate
bicalutamide
+ Grapefruit juice
Substances which are potent inhibitors of the elimination of Bicalutamide may increase Bicalutamide concentrations, and therefore, increase potential for side effects. Side effects or increased toxicity associated with Bicalutamide may be observed. Notify your health care provider if you notice changes in your infection status or other unusual effects.
Moderate
cefditoren
+ heparin
Although Anticoagulants (examples: Coumadin, heparin, Lovenox) and Cefditoren can interact, they can be used together. Taking both of these drugs may make you bruise or bleed more easily. While you are taking any Anticoagulant, watch for signs of bruising or bleeding, which may occur at any time, but especially after beginning or changing treatment with Cefditoren. Signs of bleeding include, but are not limited to, increased bruising, pinpoint red spots on your skin, or black, tarry stools. Your health care provider will closely monitor your therapy when any new medicine is added or stopped.
Moderate
niacin
+ irbesartan
Side effects from Antihypertensive Agents (drugs used to treat high blood pressure) may get worse if you take Niacin, and vice versa. Although an interaction is possible, these drugs are often used together. If the blood pressure drops too low while taking these drugs together, you may become dizzy or feel faint. Do not stand or sit up too quickly. Taking some Antihypertensive Agents can also worsen skin flushing (warm and reddened skin of the face, neck or chest), which commonly occurs after taking Niacin. Skin flushing is more common with higher doses of Niacin or with immediate-release dosage formulations of Niacin (examples: Niacor, Nicolar, Nicotinex). If skin flushing is troublesome after taking Niacin, talk to your health care provider. In some persons (who are able to take these medicines without problems), taking Aspirin or Ibuprofen 30 minutes prior to a Niacin dose can help to decrease skin flushing. Avoid alchohol or hot drinks that can worsen skin flushing while taking Niacin.
Moderate
niacin
+ Alcohol
Avoid drinking alcoholic beverages at the times you take Niacin, Niacinamide. Side effects such as skin flushing from Niacin may get worse when you drink Alcohol (also known as Ethanol) at the same time as your Niacin dose.
Moderate
niacin
+ Food
Avoid drinking hot beverages or eating hot food around the times you take Niacin. Ingesting hot food or beverages may worsen skin flushing (example: warm and reddened skin of the face, neck or chest) while taking Niacin. Alcoholic beverages may also have this effect, so also avoid drinking alcohol around the time of your Niacin dose. Taking Niacin with meals may help to decrease skin flushing.
Moderate
atropine
+ disopyramide
Although an interaction is possible, these drugs are sometimes used together. Side effects from Disopyramide may get worse if you take Antimuscarinics (examples: Atrovent, Cogentin, Cystospaz, Detrol, Ditropan, Levbid, Levsin, Transderm Scop). You may feel drowsy or more tired when taking these drugs together. Discuss any new or worsening side effects, such as constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast or slow heartbeat, or confusion, with your health care provider.
Moderate
atropine
+ aluminum hydroxide-magnesium hydroxide
Aluminum Hydroxide may decrease the absorption of Antimuscarinics (examples: Atrovent, Cogentin, Cystospaz, Detrol, Ditropan, Levbid, Levsin) from your stomach if taken at the same time. Take these drugs 1-2 hours before or after you take Aluminum Hydroxide to limit any interaction.
Moderate
atropine
+ APAP/chlorpheniramine/dextromethorphan/PSE
You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. In addition, you may experience other side effects including constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast heartbeat, or confusion.
Moderate
pimozide
+ Tobacco
In theory, Tobacco smoking may reduce the effectiveness of this drug in treating your condition; Tobacco smoke contains substances that speed the removal of this drug from the body. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may feel more drowsy or tired, or may experience confusion, dizziness, difficulty in movement or other side effects. If you will stop smoking, use care in driving or operating machinery until you know how this drug will affect you. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking. Report any unusual side effects promptly.
Moderate
linezolid
+ Alcohol
You should avoid alcoholic beverages while taking Linezolid. Side effects from Linezolid (Zyvox, an antibiotic) may get worse if you take Alcoholic beverages or medicines containing a significant amount of Alcohol. Beverages to avoid include some beers (including alcohol-free beer); wines; sherry; hard liquor; or liqueurs. Taking these beverages along with Linezolid might increase the risk of serious high blood pressure, confusion, restlessness, or other side effects.
Moderate
linezolid
+ Caffeine-containing Foods/Beverages
Try to limit caffeine intake while taking Linezolid. Side effects from Linezolid may get worse if you take Caffeine, like increased blood pressure, confusion, restlessness, or other side effects. All preparations containing caffeine should be used sparingly such as tea, coffee, chocolate, cola, or 'stay awake' products. Some nonprescription medicines also contain caffeine and should not be taken along with Linezolid.
Moderate
irbesartan
+ APAP/chlorpheniramine/dextromethorphan/PSE
Do not take cough, cold, flu and allergy products containing Pseudoephedrine (example Sudafed and many others) with your blood pressure or heart medications without talking to your health care provider. Pseudoephedrine may decrease the actions of the heart or blood pressure drug by increasing blood pressure or increasing the risk of palpitations or other side effects. Many prescription and non-prescription products contain Pseudoephedrine; read labels carefully before taking any medicine.
Moderate
irbesartan
+ Alcohol
Although an interaction is possible, Ethanol (alchohol) and Antihypertensive Agents (drugs used to reduce high blood pressure) may be used together. Ethanol or alchohol-containing beverages may increase the effects of Antihypertensive Agents on your blood pressure. If the blood pressure drops too low while taking Ethanol and Antihypertensive Agents, you may become dizzy or feel faint. To limit this interaction, avoid alcohol-containing beverages while taking medicines to lower your blood pressure. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Moderate
disopyramide
+ APAP/chlorpheniramine/dextromethorphan/PSE
You may feel drowsy or more tired when taking Disopyramide and Antihistamines together. Antihistamines are found in many allergy, cough, and hay fever products (examples: Benadryl, Dimetapp Allergy, Tavist Allergy, Zyrtec, and others). In addition, you may experience other side effects including constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast heartbeat, or confusion. Do not drive or operate machinery until you know how these drugs affect you.
Moderate
aluminum hydroxide-magnesium hydroxide
+ Alcohol
Ethanol can decrease the actions of Magnesium Salts, by increasing its elimination from the body. To get the best results, limit your intake of alcoholic beverages while taking Magnesium Salts or supplements.
Moderate
APAP/chlorpheniramine/dextromethorphan/PSE
+ Tobacco
If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.
Moderate
APAP/chlorpheniramine/dextromethorphan/PSE
+ Caffeine-containing Foods/Beverages
Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Pseudoephedrine. Also avoid medicines containing additional Caffeine whenever possible. Side effects from Pseudoephedrine may get worse if you take excessive Caffeine. Taking a high amount of Caffeine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, tremor, or other side effects.
Minor
iron polysaccharide
+ Enteral Feedings
Most iron supplements do not significantly interact with Enteral Feedings. However, Ferrous Sulfate syrups and elixirs, when given at the same time as Enteral feedings (examples: Boost, Ensure, Jevity, Sustical and others) may cause a thickening of the feeding that may increase the likelyhood of a tube clog. Such interactions are not common. However, to avoid this interaction, ferrous sulfate elixirs at least an hour before taking any nutritional supplement beverages down a tube. Alternatively, your health care professional may be able to recommend an iron supplement that would be less likely to interact.
Minor
nelfinavir
+ budesonide
Although an interaction is possible, these drugs are sometimes used together. Although unlikely with nasal or inhaled forms of Budesonide (Pulmicort, Rhinocort), side effects from Budesonide (Entocort-EC) may get worse if you take Nelfinavir (Viracept). If you notice any new or unusual reactions, contact your prescriber.
Minor
aluminum hydroxide-magnesium hydroxide
+ APAP/chlorpheniramine/dextromethorphan/PSE
Although an interaction is possible, these drugs are often used together. If you take Acetaminophen with Antacids (examples: Amphogel, Gaviscon, Maalox, Tums, Mylanta, and other products used for heartburn), then it may take longer for acetaminophen to work for you. Avoid taking Acetaminophen and Antacids at the same time.
Minor
aluminum hydroxide-magnesium hydroxide
+ APAP/chlorpheniramine/dextromethorphan/PSE
Antacids may increase the actions of Pseudoephedrine, but this interaction is likely to be minor for most persons. If you must regularly use an Antacid while taking Pseudoephedrine, take Pseudoephedrine at least 12 hours before you take your Antacid.
Minor
heparin
+ APAP/chlorpheniramine/dextromethorphan/PSE
Although an interaction is possible, these drugs are often used together. Antihistamines may decrease the actions of Heparin. Your healthcare provider will monitor your heparin therapy closely if you take these drugs together.
Minor
APAP/chlorpheniramine/dextromethorphan/PSE
+ Grapefruit juice
Grapefruit juice may increase the actions of Dextromethorphan. Side effects from the Dextromethorphan may get worse if you drink grapefruit juice. It may be best to avoid drinking grapefruit juice while you are taking Dextromethorphan.
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