Severe
APAP/butalbital/caffeine/codeine
+ Alcohol
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Patients who drink more than 3 alcoholic drinks a day and take acetaminophen are at increased risk of developing liver side effects. Avoid alcoholic drinks if you are taking acetaminophen on a regular basis.
Severe
APAP/butalbital/caffeine/codeine
+ Alcohol
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Avoid alcohol-containing drinks while taking medicines that cause drowsiness. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate
APAP/butalbital/caffeine/codeine
+ Tobacco
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If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.
Moderate
APAP/butalbital/caffeine/codeine
+ Grapefruit juice
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Side effects from Caffeine may get worse if you take Grapefruit juice or other foods that contain significant amounts of Grapefruit. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Do not significantly alter your grapefruit juice intake while taking medicines containing caffeine.
Moderate
APAP/butalbital/caffeine/codeine
+ Tobacco
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Tobacco smoke contains substances that may speed the removal of Caffeine from the body. If you start smoking Caffeine may become less effective. Tobacco smokers often drink several caffeinated beverages daily. Just the opposite occurs when someone stops smoking tobacco; if you stop smoking this may increase the amount of Caffeine in the blood and side effects from Caffeine may get worse. Too much Caffeine can cause nausea, nervousness, or sleeplessness, and occasionally other effects like tremor. If you stop smoking tobacco, you may need to lower your Caffeine intake.
Moderate
APAP/butalbital/caffeine/codeine
+ Caffeine-containing Foods/Beverages
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While taking Caffeine products, limit the use of foods, beverages, herbs and other medicines that contain additional caffeine, like coffee, teas, colas, chocolate and some diet pills. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Some drug products for adults that contain caffeine have about as much caffeine as a cup of coffee.
Minor
APAP/butalbital/caffeine/codeine
+ Caffeine-containing Foods/Beverages
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Barbiturates are commonly used for sedation, seizures or for sleep and include drugs like Amytal, Buticaps, Mysoline, Nembutal, Phenobarbital, and Seconal. Caffeine may cause sleeplessness, so if you are taking a barbiturate to help you sleep, you may wish to avoid taking caffeine and caffeine-containing foods like colas, coffee, teas, or chocolates within several hours prior to bedtime. Barbiturates may also decrease the actions of Caffeine; if you have a high intake of caffeinated foods or beverages you may experience a headache or irritability from decreased caffeine levels while taking these drugs until your body adjusts. If you take Caffeine for other purposes, notify your health care provider if you think Caffeine is not working as well for you.
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This feature is for informational purposes only and should not be used to replace the care and information received from your healthcare provider. Please consult a healthcare professional with anyhealth concerns you may have.