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  • Basic Info
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Generic: sirolimus
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It is used to decrease the immune system's response to a transplanted organ.

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What is this medicine?

SIROLIMUS (sir OH li mus) is used to decrease the immune system's response to a transplanted organ.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • heart disease or heart failure
  • high cholesterol or triglycerides
  • infection
  • liver disease
  • an unusual or allergic reaction to sirolimus, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Do not cut, crush or chew this medicine. Follow the directions on the prescription label. If you take the medicine with food, always take it with food. Do not take the medicine with grapefruit juice. If you are also taking cyclosporine, take this medicine at least 4 hours after taking your dose of cyclosporine. Take your medicine at regular intervals. You must take the medicine at the same time each day. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can, and call your doctor or health care professional. Call your doctor or health care professional if you vomit after a dose.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

- certain antibiotics like clarithromycin, erythromycin, telithromycin
- grapefruit juice
- medicines for fungal infections like itraconazole, ketoconazole, posaconazole, voriconazole
- mifepristone, RU- 486
- rifabutin, rifampin
This medicine may also interact with the following medications:

- boceprevir
- bromocriptine
- carbamazepine
- cimetidine
- cisapride
- clotrimazole
- cyclosporine
- danazol
- diltiazem
- fluconazole
- indinavir
- metoclopramide
- nicardipine
- phenobarbital
- phenytoin
- rifapentine
- ritonavir
- St. John's wort
- telaprevir
- troleandomycin
- vaccines
- verapamil

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