Attribution

This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan- Kettering Cancer Center); Mary Giles, PharmD (University of Rhode Island); Christine Park, PharmD (Northeastern University); Karta Purkh Singh Khalsa, CDN, RH (Bastyr University); Catherine DeFranco Kirkwood, MPH, CCCJS- MAC (MD Anderson Cancer Center); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

Bibliography

Brattstrom A. A newly developed extract (Ze 339) from butterbur (Petasites hybridus L.) is clinically efficient in allergic rhinitis (hay fever). Phytomedicine 2003;10 Suppl 4:50- 52.

Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43(1):76- 78.

Danesch UC. Petasites hybridus (Butterbur root) extract in the treatment of asthma- - an open trial. Altern Med Rev 2004;9(1):54- 62.

Diener HC, Rahlfs VW, Danesch U. The first placebo- controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 2004;51(2):89- 97.

Fiebich BL, Grozdeva M, Hess S, et al. Petasites hybridus extracts in vitro inhibit COX- 2 and PGE2 release by direct interaction with the enzyme and by preventing p42/ 44 MAP kinase activation in rat primary microglial cells. Planta Med 2005;71(1):12- 19.

Gray RD, Haggart K, Lee DK, et al. Effects of butterbur treatment in intermittent allergic rhinitis: a placebo- controlled evaluation. Ann Allergy Asthma Immunol 2004;93(1):56- 60.

Grossman W, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Altern Med Rev 2001;6(3):303- 310.

Grossmann M, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 2000;38(9):430- 435.

Jackson CM, Lee DK, Lipworth BJ. The effects of butterbur on the histamine and allergen cutaneous response. Ann Allergy Asthma Immunol 2004;92(2):250- 254.

Lee DK, Carstairs IJ, Haggart K, et al. Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy 2003;33(7):882- 886.

Lee DK, Gray RD, Robb FM, et al. A placebo- controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 2004;34(4):646- 649.

Lee DK, Haggart K, Robb FM, et al. Butterbur, a herbal remedy, confers complementary anti- inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 2004;34(1):110- 114.

Lipton RB, Gobel H, Einhaupl KM, et al. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 2004;63(12):2240- 2244.

Schapowal A. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324(7330):144- 146.

Thomet OA, Schapowal A, Heinisch IV, et al. Anti- inflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol 2002;2(7):997- 1006.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.