a nutraceutical product - treats Platelet aggregation, Erectile dysfunction, High blood pressure, Melasma, Asthma, Cramps, Edema, Gingival bleeding / plaque, Diabetes, Male infertility, Attention deficient hyperactivity disorder, Diabetic microangiopathy, Dysmenorrhea, High cholesterol, Migraine, Retinopathy, Sunburn, Menopausal symptoms, Venous leg ulcers, Antioxidant, Systemic lupus erythematosus, and Chronic venous insufficiency and prevents Prevention of blood clots/edema during long airplane fights
This patient information is based on a systematic review of scientific literature edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): James Ceurvels, PharmD (Northeastern University); Julie Conquer, PhD (RGB Consulting); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Sooyoun Kang, PharmD (Massachusetts College of Pharmacy); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long- haul flights with pycnogenol. Clin Appl Thromb Hemost 2004 Oct;10(4):373- 7.
Belcaro G, Cesarone MR, Errichi BM, et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol Angiology 2005 Nov- Dec;56(6):699- 705.
Belcaro G, Cesarone MR, Ricci A, et al. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin- converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost 2006 Oct;12(4):440- 4.
Cesarone MR, Belcaro G, Rohdewald P, et al. Rapid relief of signs/ symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology 2006 Oct- Nov;57(5):569- 76.
Cesarone, MR, Belcaro G, Rohdewald P, et al. Prevention of edema in long flights with pycnogenol. Clin Appl Thromb Hemost 2005;11(3):289- 294.
Chayasirisobhon S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache 2006 May;46(5):788- 93.
Dvorakova M, Jezova D, Blazícek P, et al. Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): modulation by a polyphenolic extract from pine bark (pycnogenol). Nutr Neurosci 2007 Jun- Aug;10(3- 4):151- 7.
Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res 2002;16 Suppl 1:S1- S5.
Lau BH, Riesen SK, Truong KP, et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma 2004;41(8):825- 32.
Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505- 13.
Nikolova V, Stanislavov R, Vatev I, et al. [Sperm parameters in male idiopathic infertility after treatment with prelox]. Akush Ginekol (Sofiia) 2007;46(5):7- 12.
Segger D, Schonlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double- blind, placebo- controlled study with 62 women. J Dermatolog Treat 2004;15(4):222- 226.
Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L- arginine. J Sex Marital Ther 2003;29(3):207- 213.
Tenebaum S, Paull JC, Sparrow EP. An experimental comparison of Pycnogenol and methylphenidate in adults with Attention- Deficit/ Hyperactivity Disorder (ADHD). J Atten Disord 2002;6(2):49- 60.
Yang HM, Liao MF, Zhu SY, et al. A randomised, double- blind, placebo- controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri- menopausal women. Acta Obstet Gynecol Scand 2007;86(8):978- 85.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.