a nutraceutical product - treats Platelet aggregation, Erectile dysfunction, High blood pressure, Melasma, Asthma, Cramps, Edema, Gingival bleeding / plaque, Diabetes, Male infertility, Attention deficient hyperactivity disorder, Diabetic microangiopathy, Dysmenorrhea, High cholesterol, Migraine, Retinopathy, Sunburn, Menopausal symptoms, Venous leg ulcers, Antioxidant, Systemic lupus erythematosus, and Chronic venous insufficiency and prevents Prevention of blood clots/edema during long airplane fights
Interactions with Drugs
Pycnogenol® may interact with other blood pressure lowering medications, specifically angiotensin converting enzyme inhibitors (ACE- I) such as benazepril (Lotensin®), captopril (Capoten®), enalapril (Vasotec®), fosinopril (Monopril®), lisinopril (Prinivil®), moexipril (Univasc®), perindopril (Aceon®), quinapril (Accupril®), ramipril (Altace®), trandolapril (Mavik®), or angiotensin converting enzyme receptor blockers such as losartan (Cozaar®), irbesartan (Avapro®), candesartan, cilexetil (Atacand®), or valsartan (Diovan®).
Pycnogenol® may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth (such as metformin, glyburide, glipizide) or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.
Pycnogenol® may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Pycnogenol® may have protective effects against alcohol's effects on brain neurons; further research is needed to confirm these results.
Interactions with Herbs and Dietary Supplements
Although data has yet to confirm this claim, it has been proposed that Pycnogenol® may increase vitamin C levels.
Pycnogenol® may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Pycnogenol® may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Pycnogenol® may interact with herbs and supplements that affect blood pressure. Pycnogenol® may interfere with immunosuppressant or immunostimulant herbs and supplements. Pycnogenol® and other antioxidants may have additive effects.