treats Platelet aggregation inhibition, Reactivity/brain activity, Intermittent claudication, High cholesterol, and Coronary Heart Disease
Interactions with Drugs
In theory, policosanol may interact additively with nicotinic acid (Acipimox®) or synthetic nicotinic acid due to Acipimox®'s cholesterol- lowering activity. Caution is advised in patients taking other cholesterol- lowering agents. In theory, bile acid sequestrants/ resins, ezetimibe (Zetia®), or statins (lovastatin, atorvastatin, simvastatin, pravastatin) may have an additive cholesterol- lowering effect when given with policosanol.
Policosanol may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). The addition of policosanol to warfarin therapy did not enhance the prolongation of the bleeding time induced by warfarin alone.
Policosanol may decrease arterial pressure, and thus may have additive effects with beta- blockers, or other blood pressure- lowering agents. Medication adjustments may be necessary.
Although not well studied in humans, the activity of nifedipine remained unchanged in animals treated with a high dose policosanol. There is no information regarding potential interaction with other calcium channel blockers.
Because policosanol possesses an antioxidant effect and nitric oxide can be destroyed by oxygen- derived radicals, there is a theoretical interaction between policosanol and nitroprusside and other nitrates. Consult with a qualified healthcare professional, including a pharmacist, to check for any interactions.
In theory, taking ticlopidine and policosanol together may cause an additive interaction.
Although not well studied in humans, policosanol may also interact with agents broken down by the liver, or agents taken for Alzheimer's disease, cardiovascular disorders, diabetes or neurologic disorders.
Interactions with Herbs and Dietary Supplements
In theory, there may be an additive hypotensive (blood pressure lowering) effect when policosanol is used with herbs that lower blood pressure.
In theory, additive hypocholesterolemic (cholesterol- lowering) effects may occur when policosanol is used with herbs that decrease cholesterol levels, such as plant sterols, plant stanols, polyphenols, psyllium, soy proteins, soy isoflavones, red yeast, or garlic powder.
Although not well studied in humans, policosanol may also interact with herbs and supplements broken down by the liver, or herbs and supplements taken for Alzheimer's disease, cardiovascular disorders, diabetes or neurologic disorders.