treats Platelet aggregation inhibition, Reactivity/brain activity, Intermittent claudication, High cholesterol, and Coronary Heart Disease
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antiangiogenesis, antioxidant, atheroma (fatty material that builds up in the arteries and may lead to heart problems), atherosclerotic lesions (disease of arterial blood vessels), cerebral ischemia (lack of adequate blood flow to the brain), cerebrovascular disorders (disorders of the blood vessels in the brain), heart damage, high blood pressure, iatrogenic lipodystrophy (defective metabolism), liver damage, postmenopausal osteoporosis, stroke prevention, tumor (granuloma).
Adults (18 years and older):
Typical doses of policosanol are between 5- 40 milligrams daily. Policosanol appears safe in these doses for up to three years. Based on the available evidence, this dose range is considered safe and effective in patients with coronary heart disease and for patients with type II hypercholesterolemia (high cholesterol). Doses as high as 80 grams of policosanol have been taken daily for 12 weeks to treat high cholesterol. For platelet aggregation, 10- 40 milligrams daily has been taken. For intermittent claudication, 10- 20 milligrams has been used, and for hypertension (high blood pressure), a lower dose of 5- 10 milligrams daily has been taken.
Children (younger than 18 years):
There is no proven safe or effective dose for policosanol in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with a known allergy or hypersensitivity to policosanol.
Side Effects and Warnings
Policosanol is generally regarded as safe and well tolerated. However, there are a few, minor drug- related clinical or biochemical adverse effects observed in clinical trials. Frequency of mild, moderate and serious adverse events, as well a death rate, has been shown to be lower in diabetic and non- diabetic individuals taking policosanol compared with placebo.
Policosanol may cause erythema (reddening of the skin), gum bleeding, headache, vertigo, or heartburn. Use cautiously in patients taking aspirin due to potential additive platelet inhibition and risk of bleeding. Also use caution in patients with high blood pressure or those taking agents to lower blood pressure due to a potential additive effect. Side effects of Octa- 60g (a combination product including policosanol) may include skin rash, and increased glucose and alanine aminotransferase.
Pregnancy and Breastfeeding
Policosanol is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence. Although not well studied in humans, policosanol does not appear to affect reproductive performance, fetal/ neonatal development, or breastfeeding. Additional study is needed in this area.