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  • Basic Info
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Generic: pantethine
treats Cystinosis, Athletic performance, Hyperlipidemia, and Ischemic heart disease
               



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Category

Herbs & Supplements

Synonyms

Bile acid sequestrant, bis- pantothenamidoethyl disulfide, calcium pantothenate (CaP), coenzyme Q10, carnitine, cyproheptadine, cysteamine, D- pantethine, pantetheine, pantetheinase, Pantetina, panthenol, pantomin, pantosin, pantothenic acid, sulfopantetheine, vitamin B5.

Background

Pantethine is a naturally occurring compound and the active form of pantothenic acid. Structurally, pantethine is a disulfide form of pantothenic acid; it is metabolized to coenzyme A. Pantethine received its name from the Greek word pantos, which means "everywhere" because it was in a wide variety of foods such as fish, legumes, organ meats, whole grains, and yogurt.

Research has demonstrated that pantethine, when taken by mouth, can be used for lowering cholesterol. It is also used for lowering cardiovascular risk, improving energy, improving adrenal function, and preventing allergy symptoms in people allergic to formaldehyde. Reliable evidence on pantethine for enhancing exercise performance is lacking.

Pantethine is believed to have lipid- modulating properties. It has been used to help convert fat and carbohydrates to energy. Pantethine has also been used to support adrenal function and act as an anti- stress aid.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Hyperlipidemia (high cholesterol): Numerous trials have examined the effects of pantethine taken by mouth on lipids. Reductions in total cholesterol, low- density lipoprotein (LDL), and triglycerides have occurred, however, additional study is needed in this area to confirm these findings.
Grade: B

Ischemic heart disease: Data has shown pantethine exhibits lipid- modulating effects. Additional human study is needed.
Grade: C

Athletic performance: Preliminary study does not suggest that pantethine is helpful in athletic performance. These preliminary negative results cannot be confirmed without more studies.
Grade: D

Cystinosis: Cystinosis is a hereditary dysfunction of the renal (kidney) tubules characterized by the presence of carbohydrates and amino acids in the urine, excessive urination, and low blood levels of potassium ions and phosphates, and caused by the abnormal metabolism of cystine and the accumulation of cystine crystals in tissues. Preliminary research does not show any benefit for oral pantethine in the treatment of cystinosis.
Grade: D

               
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