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  • Basic Info
Licensed from
Generic: zeaxanthin
a nutraceutical product - treats Atherosclerosis, Diabetes mellitus, Eye disorders, Obesity, Cataracts, Sunburn, Lung function, Antioxidant, Muscle soreness, Preeclampsia, and Cancer
               



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Category

Herbs & Supplements

Synonyms

Anhydroluteins, C40H56O2, Calendula officinalis, carotenoids, Compositae, crystalline lutein, helenien, Helenium autumnale L., hydroxy- carotenoids, lutein dipalmitate, lutein ester, luteine, macular pigment, marigold extract, oxygenated carotenoids, trans- lutein, xantophyll, zeaxanthin.

Background

Lutein and zeaxanthin are found in high levels in foods such as green vegetables, egg yolk, kiwi fruit, grapes, orange juice, zucchini, squash, and corn. For some commercially available supplements, lutein is extracted from marigold petals.

Lutein and zeaxanthin are carotenoids in the macular region of the retina of the eye (macular pigment), and thus lutein has been studied for its use in treating cataracts, preventing macular degeneration and retinal degeneration. Lutein and zeaxanthin also have antioxidant capabilities as well as the ability to trap short- wavelength light. The potential for carotenoids, including lutein, to play a preventing role in cardiovascular disease and cancer was recognized in the 1990s.

Most of the information surrounding lutein is based on blood and/ or dietary intakes of lutein compared with disease states (e.g. cancer, eye disorders, lung function, muscle soreness, obesity, and pre- eclampsia). More evidence is needed before recommendations can be made in these fields.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Antioxidant: Many laboratory studies have shown the antioxidant effect of lutein. However, these effects have not been confirmed in human studies.
Grade: C

Atherosclerosis: Currently, there is insufficient available evidence to recommend for or against the use of lutein for atherosclerosis (hardening of the arteries). Additional study is needed in this area.
Grade: C

Cancer: Currently, there is insufficient available evidence to recommend for or against the use of lutein for cancer. Available evidence in humans is conflicting.
Grade: C

Cataracts: Human study has not found a benefit of lutein supplementation on visual performance in people with cataracts. More information is required before a firm recommendation can be made.
Grade: C

Diabetes mellitus: Currently, there is insufficient available evidence to recommend for or against the use of lutein for diabetes. Preliminary evidence is conflicting.
Grade: C

Eye disorders (lens opacities): Spinach and collard greens, both rich in lutein, are associated with a reduced risk for age- related macular degeneration. However, preliminary evidence does not support a link between levels of lutein in the body and reduced risk for lens opacities. More information is required before a firm recommendation can be made.
Grade: C

Eye disorders (macular degeneration): Macular degeneration is a chronic disease of the eyes caused by the deterioration of the central portion of the retina, known as the macula, which is responsible for focusing central vision in the eye. Preliminary evidence suggests that consumption of spinach and collard greens, both rich in lutein, may reduce the risk for age- related macular degeneration, and other preliminary studies support this. Nonetheless, additional study is needed before a firm recommendation can be made.
Grade: C

Eye disorders (retinal degeneration): Lutein supplementation may increase macular pigment optical density in patients with retinal degeneration. However, visual effects are still unknown. Further study in humans is needed.
Grade: C

Lung function: There is early evidence of a role of carotenoids in lung function and severity of respiratory infections. However, there is no association between levels of lutein in the blood and illness severity in the elderly or in lung function in adults. More information is required in this field before a strong recommendation can be made.
Grade: C

Muscle soreness: Numerous laboratory studies have shown the antioxidant effect of lutein. Despite this, in one study a lutein- containing supplement had no effect on muscle soreness or measurements of muscle activity. More information is required in this field before a firm recommendation can be made.
Grade: C

Obesity: Currently, there is insufficient available evidence to recommend for or against the use of lutein for obesity.
Grade: C

Preeclampsia: Preeclampsis is high blood pressure related to pregnancy. Preliminary evidence suggests that preeclampsia risk may decrease with increasing concentrations of lutein. Additional human studies are needed before a firm recommendation can be made.
Grade: C

Sunburn: Numerous laboratory studies have shown the antioxidant effect of lutein. More information is required in this field before a firm recommendation can be made.
Grade: C

               
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