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  • Basic Info
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Generic: hydrochlorothiazide-spironolactone
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It helps you make more urine and lose excess water from your body
               



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What is this medicine?

HYDROCHLOROTHIAZIDE; SPIRONOLACTONE (hye droe klor oh THYE a zide; speer on oh LAK tone) is a combination of two types of diuretics. It helps you make more urine and lose excess water from your body. This medicine is used to treat high blood pressure and water retention from heart, kidney, or liver disease.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • immune system problems, like lupus
  • kidney disease
  • liver disease
  • an unusual reaction to hydrochlorothiazide, spironolactone, sulfa drugs, other medicines, foods, dyes, or preservatives
  • breast- feeding
  • pregnant or trying to get pregnant

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • ACE inhibitors like captopril, lisinopril
  • eplerenone
  • lithium
  • medicine for pain and inflammation like indomethacin
  • other diuretics
  • potassium supplements

This medicine may also interact with the following medications:

  • alcohol
  • barbiturate medicines for sleep or seizure control
  • digoxin
  • medicines for diabetes
  • medicines for high blood pressure or heart failure
  • muscle relaxers
  • neuromuscular blockers used during surgery
  • some medicines for pain like codeine
  • steroid hormones like cortisone, hydrocortisone, prednisone

               
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