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  • Basic Info
Licensed from
Generic: goldenseal
an herbal product - treats Infectious diarrhea, Common cold / upper respiratory tract infection, Heart failure, High cholesterol, Narcotic concealment, Immune system stimulation, Chloroquine-resistant malaria, and Trachoma

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This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration ( Ethan Basch, MD (Natural Standard Research Collaboration); Samuel Basch, MD (Mt. Sinai School of Medicine, NY); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Mary Coulliard PhD, RN, FNP (North County Children's Clinic); Paul Hammerness, MD (Harvard Medical School); Beth Kerbel, PharmD (Northeastern University); Michael Smith, MRPharmS., ND (Canadian College of Naturopathic Medicine); David Sollars, M.Ac, HMC (New England School of Acupuncture); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Bhowmick SK, Hundley OT, Rettig KR. Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. Clin Pediatr (Phila) 2007 Nov;46(9):831- 4.

Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/ 5 phenotypes. Clin Pharmacol Ther 2005;77(5):415- 426.

Gurley BJ, Swain A, Hubbard MA, et al. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther 2008 Jan;83(1):61- 9.

Inbaraj JJ, Kukielczak BM, Bilski P, et al. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. Chem Res Toxicol 2001;14(11):1529- 1534.

Khin MU, Myo K, Nyuat NW, et al. Clinical trial of berberine in acute watery diarrhoea. Br Med J (Clin Res Ed) 12- 7- 1985;291(6509):1601- 1605.

Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol- lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10(12):1344- 1351.

Pan GY, Huang ZJ, Wang GJ, et al. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Med 2003;69(7):632- 636.

Pan JF, Yu C, Zhu DY, et al. Identification of three sulfate- conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration. Acta Pharmacol Sin 2002;23(1):77- 82.

Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect.Dis 1987;155(5):979- 984.

Sheng WD, Jiddawi MS, Hong XQ, et al. Treatment of chloroquine- resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole. East African Medical Journal 1997;74(5):283- 284.

Wang DY, Yeh CC, Lee JH, et al. Berberine inhibited arylamine N- acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/ VGH) and brain glioblastoma multiforms (GBM 8401) cells. Neurochem Res 2002;27(9):883- 889.

Yao M, Ritchie HE, Brown- Woodman PD. A reproductive screening test of goldenseal. Birth Defects Res B Dev Reprod Toxicol 2005 Oct;74(5):399- 404.

Yin J, Hu R, Chen M, et al. Effects of berberine on glucose metabolism in vitro. Metabolism 2002;51(11):1439- 1443.

Yount G, Qian Y, Moore D, et al. Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro. J Exp Ther Oncol 2004;4(2):137- 143.

Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 7- 15- 2003;92(2):173- 176.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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