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  • Basic Info
Licensed from
Generic: goldenseal
an herbal product - treats Infectious diarrhea, Common cold / upper respiratory tract infection, Heart failure, High cholesterol, Narcotic concealment, Immune system stimulation, Chloroquine-resistant malaria, and Trachoma
               



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Interactions

Interactions with Drugs

Goldenseal or its component berberine could increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti- platelet drugs such as clopidogrel (Plavix®), and non- steroidal anti- inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Goldenseal may interfere with the way the body processes certain drugs using the cytochrome P450 liver enzyme system. As a result, the levels of these drugs may be increased in the blood and this may cause increased effects or potentially serious adverse reactions. Chemicals in goldenseal may increase the effects of L- phenylephrine and decrease the effects of tetracycline, neostigmine, or yohimbine.

Berberine may reduce the gastrointestinal absorption of P- glycoprotein mediated substrates including chemotherapeutic agents such as daunomycin.

Berberine may lower blood sugar. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.

Berberine may lower cholesterol and triglycerides levels, increasing the effects of some drugs like lovastatin (Mevacor®).

Interactions with beta- blockers or 1,3,- bisC2- chloroethyn- 1- nitosurea (BCNU) may occur.

Interactions with Herbs and Dietary Supplements

Goldenseal or its component berberine could increase the risk of bleeding when taken with herbs or supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Goldenseal may interfere with the way the body processes certain herbs and supplements using a liver enzyme called cytochrome P450. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system, such as bloodroot, cat's claw, or chamomile. The goldenseal component berberine may reduce the effectiveness of yohimbine, which is found in small amounts in yohimbe bark extract.

Berberine may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Berberine may lower cholesterol and triglycerides levels increasing the effects of some herbs and supplements like red rice yeast and guggul.

               
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