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  • Basic Info
Licensed from
Generic: feverfew
an herbal product - treats Rheumatoid arthritis and Migraine headache prevention

To get info about second drug, type a name above.


This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration ( Ernie- Paul Barrette, MD (Case Western Reserve University School of Medicine); Ethan Basch, MD, MPhil (Memorial Sloan- Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Paul Hammerness, MD (Harvard Medical School); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Anh Le, PhD (Emory University); Michael Smith MRPharmS, ND (Canadian College of Naturopathic Medicine); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Curry EA III, Murry DJ, Yoder C, et al. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs 2004;22(3):299- 305.

DeWeerdt CJ, Bootsman H, Hendricks H. Herbal medicines in migraine prevention. Randomized double- blind placebo- controlled crossover trial of a feverfew preparation. Phytomed 1996;3(3):225- 230.

Diener HC, Pfaffenrath V, Schnitker J, et al. 2005 Nov;25(11):1031- 41. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2- extract (MIG- 99) in migraine prevention- - a randomized, double- blind, multicentre, placebo- controlled study.

Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3(4A):509- 514.

Kuritzky A, Elhacham Y, Yerushalmi Z, et al. Feverfew in the treatment of migraine: its effect on serotonin uptake and platelet activity. Neurology 1994;44(Suppl 2):A201.

Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 2004;44(9):885- 890.

Murphy JJ, Heptinstall S, Mitchell JR. Randomised double- blind placebo- controlled trial of feverfew in migraine prevention. Lancet 7- 23- 1988;2(8604):189- 192.

Palevitch D, Earon G, Carasso R. Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: a double- blind placebo- controlled study. Phytother Res 1997;11(7):508- 511.

Pattrick M, Heptinstall S, Doherty M. Feverfew in rheumatoid arthritis: a double blind, placebo controlled study. Ann Rheum Dis 1989;48(7):547- 549.

Pittler MH, Vogler BK, Ernst E. Feverfew for preventing migraine (Cochrane Review). The Cochrane Library 2000;(4):CD002286.

Shrivastava R, Pechadre JC, John GW. Tanacetum parthenium and Salix alba (Mig- RL) combination in migraine prophylaxis: a prospective, open- label study. Clin Drug Investig 2006;26(5):287- 96.

Sriramarao P, Rao PV. Allergenic cross- reactivity between Parthenium and ragweed pollen allergens. Int Arch Allergy Immunol 1993;100(1):79- 85.

Vogler BK, Pittler MH, Ernst E. Feverfew as a preventive treatment for migraine: a systematic review. Cephalalgia 1998;18(10):704- 708.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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