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  • Basic Info
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Generic: estradiol-norethindrone
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It is used as hormone replacement in menopausal women who still have their uterus
               



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What is this medicine?

ESTRADIOL; NORETHINDRONE (es tra DYE ole; nor eth IN drone) is used as hormone replacement in menopausal women who still have their uterus. This product helps to treat hot flashes and prevent osteoporosis (weak bones).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease or blood clots
  • breast, cervical, endometrial, or uterine cancer
  • diabetes
  • endometriosis
  • fibroids
  • gallbladder disease
  • heart disease or recent heart attack
  • high blood cholesterol
  • high blood pressure
  • high level of calcium in the blood
  • hysterectomy
  • kidney disease
  • liver disease
  • mental depression
  • migraine headaches
  • porphyria
  • stroke
  • systemic lupus erythematosus (SLE)
  • tobacco smoker
  • vaginal bleeding
  • an unusual or allergic reaction to estrogens, progestins, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a drink of water. You may take this medicine with food. Follow the directions on the prescription label. You will take one tablet daily at roughly the same time each day. Do not take your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • barbiturates, such as phenobarbital
  • benzodiazepines
  • bosentan
  • bromocriptine
  • carbamazepine
  • cimetidine
  • cyclosporine
  • dantrolene
  • grapefruit juice
  • griseofulvin
  • hydrocortisone, cortisone, or prednisolone
  • isoniazid (INH)
  • medications for diabetes
  • methotrexate
  • mineral oil
  • phenytoin
  • raloxifene
  • rifabutin, rifampin, or rifapentine
  • tamoxifen
  • thyroid hormones
  • topiramate
  • tricyclic antidepressants
  • warfarin

               
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