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What is this medicine?

DIPHENHYDRAMINE; PHENYLEPHRINE (dye fen HYE dra meen; fen il EF rin) is a combination of an antihistamine and a decongestant. It is used to treat the symptoms of allergies, a cold, or other sinus problems. It may help with congestion and runny nose. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • phenylketonuria
  • stomach ulcer or obstruction
  • thyroid disease
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate within the last 14 days
  • trouble passing urine
  • an unusual or allergic reaction to diphenhydramine, phenylephrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bromocriptine
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:

  • alcohol
  • atropine
  • barbiturates like phenobarbital
  • bretylium
  • caffeine
  • digoxin
  • linezolid
  • mecamylamine
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • muscle relaxers
  • narcotic medicines for pain
  • other medicines for cold, cough, or allergy
  • procarbazine
  • St. John's Wort
  • theophylline

               
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