Generic: dimethyl sulfoxide
a genitourinary tract agent - treats Interstitial cystitis, Surgical skin flap ischemia, Diabetic ulcers, Extravasation, Reflex sympathetic dystrophy, Amyloidosis, Rheumatoid arthritis, Anesthesia, Herpes zoster, Pressure ulcers, Scleroderma, Tendopathies, Inflammatory bladder disease, Gastritis, and Intracranial pressure
Interactions with Drugs
Using DMSO with sulindac (Clinoril®) may cause peripheral neuropathy. Animal studies have reported that the action of sulindac may be decreased by DMSO. Although human data is lacking, this drug combination should be avoided.
Interactions with Herbs and Supplements
Insufficient available information.
This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Ethan Basch, MD (Memorial Sloan- Kettering Cancer Center); Heather Boon, B.Sc.Phm, PhD (University of Toronto); Thomas Brendler, BA (PlantaPhile, Berlin); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Catherine DeFranco Kirkwood, MPH, CCCJS- MAC (MD Anderson Cancer Center); Joerg Gruenwald, PhD (Phytopharm Consulting); Dana A. Hackman, BS (Northeastern University); David Keifer, MD (University of Arizona); Benjamin Kligler, MD, MPH (Continuum Center for Health and Healing); Hope J. Lafferty, AM (Memorial Sloan- Kettering Cancer Center); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collabroation); Jen Woods, BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Barker SB, Matthews PN, Philip PF, et al. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59(2):142- 144.
Bauwens D, Hantson P, Laterre PF, et al. Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide- preserved stem cell infusion. Leuk Lymphoma 2005 Nov;46(11):1671- 4.
Bertelli G, Gozza A, Forno GB, et al. Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study. J Clin Oncol 1995;13(11):2851- 2855.
Chen- Plotkin AS, Vossel KA, Samuels MA, et al. Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation. Neurology 2007 Mar 13;68(11):859- 61.
Dawson TE, Jamison J. Intravesical treatments for painful bladder syndrome/ interstitial cystitis. Cochrane Database Syst Rev 2007 Oct 17;(4):CD006113.
Demir E, Kilciler M, Bedir S, et al. Comparing two local anesthesia techniques for extracorporeal shock wave lithotripsy. Urology 2007 Apr;69(4):625- 8.
Duimel- Peeters IG, J G Halfens R, Ambergen AW, et al. The effectiveness of massage with and without dimethyl sulfoxide in preventing pressure ulcers: a randomized, double- blind cross- over trial in patients prone to pressure ulcers. Int J Nurs Stud 2007 Nov;44(8):1285- 95.
Karaca M, Bilgin UY, Akar M, et al. Dimethly sulphoxide lowers ICP after closed head trauma. Eur J Clin Pharmacol 1991;40(1):113- 114.
Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997;73(2):123- 139.
Kneer W, Kuhnau S, Bias P, et al. [Dimethylsulfoxide (DMSO) gel in treatment of acute tendopathies. A multicenter, placebo- controlled, randomized study]. Fortschr Med 1994;112(10):142- 146.
Olver IN, Aisner J, Hament A, et al. A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation. J Clin Oncol 1988;6(11):1732- 1735.
Ozkaya- Bayazit E, Kavak A, Gungor H, et al. Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis. Int J Dermatol 1998;37(12):949- 954.
Rademaker- Lakhai JM, van den BD, Pluim D, et al. A Phase I and pharmacological study with imidazolium- trans- DMSO- imidazole- tetrachlororuthenate, a novel ruthenium anticancer agent. Clin Cancer Res 2004;10(11):3717- 3727.
Takeda T, Kozakai N, Ikeuchi K. Localized amyloidosis of the bladder treated effectively by occlusive dressing technique therapy using Dimethyl sulfoxide (DMSO): two case reports] ippon Hinyokika Gakkai Zasshi 2005 Nov;96(7):705- 8.
Zuurmond WW, Langendijk PN, Bezemer PD, et al. Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream. Acta Anaesthesiol Scand 1996;40(3):364- 367.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.