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  • Basic Info
Licensed from
Generic: creatine
a nutraceutical product - treats Adjunct in surgery, Dialysis, Depression, Multiple sclerosis, Apnea, GAMT deficiency, Bone density, Spinal cord injury, Congestive heart failure, Enhanced athletic performance and endurance, Hyperornithinemia, Myocardial infarction, Chronic obstructive pulmonary disease, Huntington's disease, Memory, Amyotrophic lateral sclerosis, Neuromuscular disorders, High cholesterol, Ischemic heart disease, Muscular dystrophy, Surgical recovery, Enhanced muscle mass / strength, and McArdle's disease

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This information is based on a professional level monograph edited and peer- reviewed by contributors to the Natural Standard Research Collaboration ( Ethan Basch, MD (Memorial Sloan- Kettering Cancer Center); Stefan Bughi, MD (University of Southern California); Jessica Clubb, PharmD (Northeastern University); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Natural Standard Research Collaboration); Theresa Davies- Heerema, PhD (Boston School of Medicine); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).


DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Branch JD. Effect of creatine supplementation on body composition and performance: a meta- analysis. Int J Sport Nutr Exerc Metab 2003;13(2):198- 226.

Cramer JT, Stout JR, Culbertson JY, et al. Effects of creatine supplementation and three days of resistance training on muscle strength, power output, and neuromuscular function. J Strength Cond Res 2007 Aug;21(3):668- 77.

Escolar DM, Buyse G, Henricson E, et al. CINRG Group. CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy.Ann Neurol 2005 Jul;58(1):151- 5.

Faager G, Söderlund K, Sköld CM, et al. Creatine supplementation and physical training in patients with COPD: a double blind, placebo- controlled study. Int J Chron Obstruct Pulmon Dis 2006;1(4):445- 53.

Groeneveld JG, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53(4):437- 445.

Javierre C, Barbany JR, Bonjorn VM, et al. Creatine supplementation and performance in 6 consecutive 60 meter sprints.J Physiol Biochem. 2004 Dec;60(4):265- 71.

Kendall RW, Jacquemin G, Frost R, et al. Creatine supplementation for weak muscles in persons with chronic tetraplegia: a randomized double- blind placebo- controlled crossover trial. J Spinal Cord Med 2005;28(3):208- 13.

McMorris T, Mielcarz G, Harris RC, et al. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2007 Sep;14(5):517- 28.

NINDS NET- PD Investigators. A randomized, double- blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006 Mar 14;66(5):664- 71.

Pluim BM, Ferrauti A, Broekhof F, et al. The effects of creatine supplementation on selected factors of tennis specific training. Br J Sports Med 2006 Jun;40(6):507- 11; discussion 511- 2.

Roitman S, Green T, Osher Y, et al. Creatine monohydrate in resistant depression: a preliminary study. Bipolar Disord 2007 Nov;9(7):754- 8.

Roy BD, de Beer J, Harvey D, et al. Creatine monohydrate supplementation does not improve functional recovery after total knee arthroplasty. Arch Phys Med Rehabil 2005 Jul;86(7):1293- 8.

Schneider- Gold C, Beck M, Wessig C, et al. Creatine monohydrate in DM2/ PROMM: a double- blind placebo- controlled clinical study. Proximal myotonic myopathy. Neurology 2- 11- 2003;60(3):500- 502.

Skare OC, Skadberg, Wisnes AR. Creatine supplementation improves sprint performance in male sprinters. Scand.J Med Sci.Sports 2001;11(2):96- 102.

Vorgerd M, Zange J, Kley R, et al. Effect of high- dose creatine therapy on symptoms of exercise intolerance in McArdle disease: Double- blind, placebo- controlled crossover study. Arch Neurol 2002;59(1):97- 101.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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