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  • Basic Info
Licensed from
Generic: clove
an herbal product - treats Dental pain, Fever reduction, Mosquito repellent, and Premature ejaculation

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Adults (18 years and older)

There is not enough scientific evidence available to recommend a specific dose of clove by mouth, on the skin, or by any other route.

Children (younger than 18 years)

There is not enough scientific evidence available to recommend a specific dose of clove by mouth, on the skin, or by any other route.


DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.


Allergic reactions to clove, its component eugenol have been reported, including possible severe reactions (anaphylaxis). Signs of allergy may include rash, itching or shortness of breath. Eugenol or clove can cause allergic rashes when applied to skin or inside the mouth. Hives have been reported in clove cigarette smokers. Individuals with known allergy to clove, its component eugenol, or to Balsam of Peru should avoid the use of clove by mouth, inhaled from cigarettes, or applied to the skin.

Side Effects and Warnings

Clove is generally regarded as safe for food use in the United States. However, when clove is taken by mouth in large doses, in its undiluted oil form, or used in clove cigarettes, side effects may occur including vomiting, sore throat, seizure, sedation, difficulty breathing, fluid in the lungs, vomiting of blood, blood disorders, kidney failure, and liver damage or failure. People with kidney or liver disorders or who have had seizures should avoid clove. Serious side effects are reported more often in young children, even with small doses, and therefore clove supplements should be avoided in children and pregnant or nursing women.

Clove or clove oil may cause an increased bleeding risk, based largely on laboratory research. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary. It is not clear what doses or methods of using clove may increase this risk. Clove use should be stopped before surgery.

When applied to the skin or inside of the mouth, clove can cause burning, loss of sensation or painful sensation, local tissue damage, dental pulp damage, higher risk of cavities, or sore lips. Undiluted clove oil has a high risk of causing contact dermatitis (rash) and even burns if applied to the skin at full strength. The application of clove combination herbal creams to the penis has been said to cause episodes of difficulty with erection or ejaculation.

Clove oil taken by mouth may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare provider, and medication adjustments may be necessary.

Contamination can occur if clove is improperly stored.

Pregnancy and Breastfeeding

Not enough information about safety is available to recommend the use of clove supplements in pregnant or breastfeeding women.

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