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  • Basic Info
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Generic: cisapride
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It is used to treat heartburn in patients with gastroesophageal reflux disease (GERD)

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What is this medicine?

CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). Because of the serious risks associated with this medicine it should only be used when lifestyle changes and other medicines have not worked. This medicine in only available from your doctor, who must register with the drug company and meet certain criteria for the use of this drug. Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following toll- free number (877) 795- 4247.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • eating disorder, like anorexia or bulimia
  • heart disease or heart failure
  • heart rhythm problems
  • heart valve problems
  • history of low levels of calcium, potassium, or magnesium
  • kidney disease
  • liver disease
  • lung disease
  • stomach bleeding, blockage, or ulceration
  • an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast- feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the label. Take this medicine on an empty stomach, at least 15 minutes before eating and at bedtime. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alfuzosin
  • apomorphine
  • aprepitant
  • arsenic trioxide
  • certain antibiotics
  • certain medicines for cancer like daunorubicin and doxorubicin
  • chloroquine
  • cimetidine
  • clozapine
  • conivaptan
  • cyclobenzaprine
  • cyclosporine
  • danazol
  • diltiazem
  • dolasetron
  • droperidol
  • ethinyl estradiol
  • general and local anesthetics
  • grapefruit juice
  • halofantrine
  • haloperidol
  • hawthorn
  • imatinib
  • isoniazid
  • levomethadyl
  • medicines for fungal infections like ketoconazole and itraconazole
  • medicines for HIV
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines used to treat erectile dysfunction (ED) like sildenafil, tadalafil, and vardenafil
  • methadone
  • mifepristone
  • nicardipine
  • octreotide
  • palonosetron
  • pentamidine
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • pimozide
  • quinine
  • ranolazine
  • risperidone
  • sodium phosphates
  • some medicines for treating heart- rhythm problems
  • tacrolimus
  • verapamil
  • zafirlukast
  • zileuton
  • ziprasidone

This medicine may also interact with the following medications:

  • diuretics
  • insulin

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