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  • Basic Info
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Generic: cholecalciferol
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a vitamin - treats Osteogenesis imperfecta, Proximal myopathy, Fall prevention, Colorectal cancer, Skin pigmentation disorders, Vitamin D deficiency, Hepatic osteodystrophy, Muscle weakness/pain, Immunomodulation, Muscle strength, Fanconi syndrome-related hypophosphatemia, Mortality reduction, Psoriasis, Hypocalcemia due to hypoparathyroidism, Cancer prevention, Breast cancer prevention, Senile warts, Tooth retention, Corticosteroid-induced osteoporosis, Anticonvulsant-induced osteomalacia, Hypertriglyceridemia, Multiple sclerosis, High blood pressure, Osteoporosis, Diabetes, Seasonal affective disorder, Myelodysplastic syndrome, Prostate cancer, Familial hypophosphatemia, Rickets, Renal osteodystrophy, Weight gain, Hyperparathyroidism due to low vitamin D levels, and Osteomalacia
               



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Attribution

This information is based on a systematic review of scientific literature, and has been edited and peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD, MSc, MPhil (Memorial Sloan Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (University of Rhode Island); Dana A. Hackman, BS (Northeastern University); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, PharmD (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta- analysis of randomized controlled trials. Arch Intern Med 2007 Sep 10;167(16):1730- 7.

Deane A, Constancio L, Fogelman I, et al. The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long- term use in post- menopausal osteoporosis. BMC Musculoskelet Disord 2007 Jan 10;8:3.

Goldstein MR. Myopathy, statins, and vitamin D deficiency. Am J Cardiol. 2007 Oct 15;100(8):1328. Epub 2007 Jun 29. Comment on: Am J Cardiol 2007 Apr 15;99(8):1171- 6.

Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis Am J Prev Med 2007 Mar;32(3):210- 6.

Helfrich YR, Kang S, Hamilton TA, et al. Topical becocalcidiol for the treatment of psoriasis vulgaris: a randomized, placebo- controlled, double- blind, multicentre study. Br J Dermatol 2007 Aug;157(2):369- 74.

Izaks GJ. Fracture prevention with vitamin D supplementation: considering the inconsistent results. BMC Musculoskelet Disord 2007 Mar 9;8:26.

Lappe JM, Travers- Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007 Jun;85(6):1586- 91.

Lind L, Wengle B, Wide L, et al. Reduction of blood pressure during long- term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status. A double- blind, placebo- controlled study. Am J Hypertens 1989;2(1):20- 25.

Lyons RA, Johansen A, Brophy S, et al. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int 2007 Jun;18(6):811- 8.

Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta- analysis. J Clin Endocrinol Metab 2007 Jun;92(6):2017- 29.

Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study. Cancer Causes Control 2007 Sep;18(7):775- 82.

Schumann SA, Ewigman B. Double- dose vitamin D lowers cancer risk in women over 55. J Fam Pract 2007 Nov;56(11):907- 10.

Tau C, Ciriani V, Scaiola E, et al. Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina. J Steroid Biochem Mol Biol 2007 Mar;103(3- 5):651- 4.

Wactawski- Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006 Feb 16;354(7):684- 96.

Wagner CL, Greer FR, Section on Breastfeeding and Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 2008; 122(5): 1142- 1152.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

               
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