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  • Basic Info
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Generic: caprylic acid
treats Epilepsy
               



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Interactions

Interactions with Drugs

Caprylic acid may alter the effects of drugs that are highly bound to albumin. Patients taking any medications should check the package insert, and consult with a qualified healthcare professional, including a pharmacist.

Theoretically, caprylic acid may increase susceptibility to carbaryl exposure and decrease the body's ability to clear carbaryl, a highly toxic insecticide. Caution is advised.

Indomethacin can inhibit the cardiovascular effects of octanoic acid. Patients taking cardiovascular medications should consult with a qualified healthcare professional, including a pharmacist, about interactions.

Although not well studied in humans, caprylic acid may also interact with inotropic agents, nimodipine, phenylbutazone, warfarin and non- steroidal anti- inflammatory drugs (NSAIDS).

Interactions with Herbs and Dietary Supplements

Octanoic acid may alter the effects of non- steroidal anti- inflammatory agents. Caution is advised in patients taking herbs and supplements that have similar effects as non- steroidal anti- inflammatory agents.

Attribution

This information is based on a systematic review of scientific literature, and was peer- reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ashley Brigham, PharmD (Northeastern University); J. Katherine Bryan, BA (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Thuy- Duong Le, PharmD (Oregon State University); Elizabeth A. Poole, PharmD; Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Wendy Weissner, BA (Natural Standard Research Collaboration); Heeja Yoon, PharmD (Drake University).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Giannakou SA, Dallas PP, Rekkas DM, et al. In vitro evaluation of nimodipine permeation through human epidermis using response surface methodology. Int J Pharm 7- 8- 2002;241(1):27- 34.

Han J, Hamilton JA, Kirkland JL, et al. Medium- chain oil reduces fat mass and down- regulates expression of adipogenic genes in rats. Obes Res 2003;11(6):734- 744.

Hoshimoto A, Suzuki Y, Katsuno T, et al. Caprylic acid and medium- chain triglycerides inhibit IL- 8 gene transcription in Caco- 2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol 2002;136(2):280- 286.

Kalantar- Zadeh K, Braglia A, Chow J, et al. An anti- inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/ feasibility study. J Ren Nutr 2005;15(3):318- 331.

Lima TM, Kanunfre CC, Pompeia C, et al. Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis. Toxicol In Vitro 2002;16(6):741- 747.

McLay JC, Kennedy MJ, Orourke AL, et al. Inhibition of bacterial foodborne pathogens by the lactoperoxidase system in combination with monolaurin. Int J Food Microbiol. 2- 25- 2002;73(1):1- 9.

Nagata J, Kasai M, Negishi S, et al. Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. Biofactors 2004;22(1- 4):157- 160.

Nair MK, Joy J, Venkitanarayanan KS. Inactivation of Enterobacter sakazakii in reconstituted infant formula by monocaprylin. J Food Prot. 2004;67(12):2815- 2819.

Olsen H, Andersen A, Nordbo A, et al. Pharmaceutical- grade albumin: impaired drug- binding capacity in vitro. BMC.Clin Pharmacol 3- 29- 2004;4:4.

Robertson MD, Jackson KG, Fielding BA, et al. Acute ingestion of a meal rich in n- 3 polyunsaturated fatty acids results in rapid gastric emptying in humans. Am J Clin Nutr 2002;76(1):232- 238.

Robinson MK. Population differences in acute skin irritation responses. Race, sex, age, sensitive skin and repeat subject comparisons. Contact Dermatitis 2002;46(2):86- 93.

Samsom M, Vermeijden JR, Smout AJ, et al. Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients. Diabetes Care 2003;26(11):3116- 3122.

Schneider AR, Kraut C, Lindenthal B, et al. Total body metabolism of 13C- octanoic acid is preserved in patients with non- alcoholic steatohepatitis, but differs between women and men. Eur J Gastroenterol Hepatol 2005;17(11):1181- 1184.

Sogorb MA, Carrera V, Vilanova E. Hydrolysis of carbaryl by human serum albumin. Arch Toxicol. 2004;78(11):629- 634.

Wanten GJ, Janssen FP, Naber AH. Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain- length. Eur J Clin Invest 2002;32(4):285- 289.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

               
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