a vitamin b complex - treats Diabetes mellitus, Hepatitis, Biotin-responsive inborn errors of metabolism, Pregnancy supplementation, Biotin deficiency, Total parenteral nutrition, Cardiovascular disease risk, and Brittle fingernails
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Alopecia areata (hair loss), antioxidant, basal ganglia disease, cancer, Crohn's disease, exercise capacity improvement, hyperlipidemia, metabolic disorders (3- methylcrotonylglycinuria), Parkinson's disease, peripheral neuropathy, Rett syndrome, seborrheic dermatitis, uncombable hair syndrome, vaginal candidiasis, wound healing (periodontal).
Adults (18 years and older)
The U.S. Food and Nutrition Board of the National Academy of Science's Institute of Medicine recommends a daily Adequate Intake (AI) of 30 micrograms in adults 19 years and older (a daily AI of 25 micrograms is recommended in those ages 14- 18 years old). In pregnant women older than 14 years, an AI of 30 micrograms is recommended. During breastfeeding, a daily AI of 35 micrograms is recommended. Most healthy non- pregnant individuals with regular diets obtain these amounts of biotin through dietary consumption.
The U.S. Recommended Dietary Allowance (RDA) for biotin is 300 micrograms daily. This is the dose used in many dietary supplements. Toxicity with biotin intake has not been reported in the available literature, and doses as high as 200 milligrams daily have been used in patients with inborn errors of metabolism without significant reported toxicity.
Biotin is available as capsules and tablets in various doses and as lozenges. Treatment for biotin deficiency should be under strict medical supervision. There is disagreement among experts about the proper dose. In adults, intramuscular (injected into the muscle) doses as low as 150- 300 micrograms daily have been suggested. Higher doses between 10- 40 milligrams of biotin daily have also been recommended (given by mouth, injected into the muscle, or injected into the veins).
Children (younger than 18 years)
The U.S. Food and Nutrition Board of the National Academy of Science's Institute of Medicine recommends a daily Adequate Intake (AI) of 5 micrograms daily (~0.7 micrograms per kilogram) in infants ages 0- 6 months old; 6 micrograms daily (~0.7 micrograms per kilogram) in infants ages 7- 12 months old; 8 micrograms daily in children ages 1- 3 years old; 12 micrograms daily in children ages 4 8 years- old; 20 micrograms daily in children ages 9- 13 years old; and 25 micrograms in adolescents ages 14- 18 years old.
Treatment for biotin deficiency and biotin- responsive inborn errors of metabolism should be under strict medical supervision. There is disagreement among experts about the proper dose.