a vitamin b complex - treats Diabetes mellitus, Hepatitis, Biotin-responsive inborn errors of metabolism, Pregnancy supplementation, Biotin deficiency, Total parenteral nutrition, Cardiovascular disease risk, and Brittle fingernails
This information was created based on a systematic review of the scientific literature, and was peer- reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Ethan Basch, MD (Memorial Sloan- Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cynthia Dacey, PharmD (Northeastern University); Shaina Tanguay- Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Christine Ulbricht, BS (University of Massachusetts); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration.
BibliographyDISCLAIMER: Natural Standard developed the above evidence- based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Adhisivam B, Mahto D, Mahadevan S. et al. Biotin responsive limb weakness. Indian Pediatr. 2007 Mar;44(3):228- 30.
Albarracin C, Fuqua B, Geohas J, et al. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo- controlled, double- blind randomized clinical trial. J Cardiometab Syndr 2007 Spring;2(2):91- 7.
Baumgartner ER, Suormala T. Multiple carboxylase deficiency: inherited and acquired disorders of biotin metabolism. Int J Vitam Nutr Res 1997;67(5):377- 384.
Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:374- 389.
Friebel D, von der Hagen M, Baumgartner ER, et al. The first case of 3- methylcrotonyl- CoA carboxylase (MCC) deficiency responsive to biotin. Neuropediatrics 2006 Apr;37(2):72- 8.
Geohas J, Daly A, Juturu V, et al. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo- controlled, double- blinded, randomized clinical trial. Am J Med Sci 2007 Mar;333(3):145- 53.
Mock DM, Mock NI, Nelson RP, et al. Disturbances in biotin metabolism in children undergoing long- term anticonvulsant therapy. J Pediatr Gastroenterol Nutr 1998;26(3):245- 250.
Mock DM, Stadler DD, Stratton SL, et al. Biotin status assessed longitudinally in pregnant women. J Nutr 1997;127(5):710- 716.
Neiva RF, Al- Shammari K, Nociti FH Jr, et al. Effects of vitamin- B complex supplementation on periodontal wound healing. J Periodontol 2005 Jul;76(7):1084- 91.
Revilla- Monsalve C, Zendejas- Ruiz I, Islas- Andrade S, et al. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia. Biomed Pharmacother 2006 May;60(4):182- 5.
Seymons K, De Moor A, De Raeve H, et al. Dermatologic signs of biotin deficiency leading to the diagnosis of multiple carboxylase deficiency. Pediatr Dermatol 2004;21(3):231- 235.
Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo- controlled, double- blinded, randomized trial.
Stewart S, Prince M, Bassendine M, et al. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol 2007 Aug;47(2):277- 83.
Strom CM, Levine EM. Chronic vaginal candidiasis responsive to biotin therapy in a carrier of biotinidase deficiency. Obstet Gynecol 1998;92(4 Pt 2):644- 646.
van den BH. Bioavailability of biotin. Eur J Clin Nutr 1997;51 Suppl 1:S60- S61.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.